Modern Aspects of Etiological Diagnostics, Clinical Picture and Treatment of Severe Community-Acquired Pneumonia in Soldiers

Abstract

The problem of community-acquired pneumonia is one of the most relevant for military medicine. The relevance of community-acquired pneumonia is determined by the high incidence of conscription by military personnel, the severity of the clinical course, the presence of severe complications, the duration of labor losses, the tendency to epidemic spread, and the risk of deaths. It is necessary to improve laboratory research methods with the introduction of express methods for verifying bacterial and viral agents, determining the clinical features of the viral-bacterial pneumonia, and justifying the inclusion of antiviral agents in the etiotropic treatment regimen. An expanded complex of microbiological diagnosis of pneumonia has been developed, combining classical bacteriological methods with express methods (polymerase chain reaction, enzyme- linked immunosorbent assay, immunochromatography), which made it possible to determine atypical pathogens and viruses in addition to agents of a bacterial nature. Using these techniques, the modern etiological structure of community-acquired pneumonia in the military has been established, the prevalence of viral-bacterial pneumonia has been revealed. Among viruses, the leadership of adenovirus infection has been established, clinical and laboratory features of the disease are shown depending on the pathogens identified, the feasibility of additional prescribing of antiviral agents in addition to antibiotics in the treatment of viral-bacterial pneumonia is justified.

ROLE OF METALLOPROTEINASE-12-82A>G GENE SNP IN THE PATHOGENESIS OF COMMUNITY-ACQUIRED PNEUMONIA IN CONTRACTION-AGE PATIENTS

“…Военный призыв является мощным стрессорным фактором, который может приводить к развитию синдрома хронического адаптационного перенапряжения и, как следствие, к дисбалансу различных систем организма, в том числе иммунной системы, системы ПОЛ-антиоксиданты и пр. [2].…”

“…Этиологическую расшифровку возбудителей внебольничных пневмоний осуществляли с помощью ПЦР назофарингиальных мазков и мокроты для обнаружения РНК/ДНК вирусов, бактерий, атипичных патогенов [2]. Генетические исследования для определения мутации MMP12-82(A>G) осуществляли, используя набор праймеров «Литех»-«SNP» (Россия).…”