Modern Approaches to the Development of Reference Standards for Quality Assessment of Drug Substances

Меркулов, В. А.; Sakanyan, E. I.; Климов, В. И.; Shemeryankina, T. B.; Yashkir, V. A.; Бармин, А. В.

doi:10.1007/s11094-016-1369-2

Cited by 8 publications

(1 citation statement)

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“…The company has registered 100 types of drugs. The specialized laboratory of "Vifiteh" carries out phased quality control of drugs and improves methods for the standardization of phytopreparations [52]. In the analysis of the authenticity of phytopreparations, standard samples of terpenoids are used: bornyl acetate for the preparation "Urohol", menthol, cineol -"Pectusin", tyrosol -"Rhodiola liquid extract", eucalymin -"Chlorophyllipt".…”

Section: Ohmentioning

confidence: 99%

Production Technology of Phytopreparations Based on Essential Oils

Shaimerdenova¹

2019

Eurasian Chem. Tech. J.

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The article provides an overview of phytopreparations technology based on essential oils, in particular: criteria for the selection of components, qualitative and quantitative compositions analyzes, parameters of the technological cycle of production of drugs, problems of standardization and quality control of stages of the production of original drugs. A number of standard samples based on terpenoids for phased quality control of the production of medicinal products are described, which are included in the European, Kazakhstan and Japanese pharmacopeias. The main countries producing essential oils and their components, as well as manufacturers of phytopreparations based on them are indicated. The modern technologies for the production of essential oils from plant materials are reviewed, namely: microwave and ultrasonic extractions, supercritical carbon dioxide extraction and micro-steam distillation with solid phase microextraction. The dosage forms of preparations based on essential oils (tablets, ointments, gels, oil solutions, suppositories, sprays, aerosols, nanocapsules), their relationship with bioavailability and therapeutic effect are discussed. Promising dosage forms that ensure dosage accuracy for the targeted action of drugs based on essential oils have been identified.

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Section: Ohmentioning

confidence: 99%