Moderately increased alcohol consumption is associated with higher pressure wave reflections and blood pressure in men

Basdeki, Eirini D.; Tsirimiagkou, Christiana; Argyris, Antonis; Moschonis, George; Sfikakis, Petros P.; Protogerou, Athanase D.; Karatzi, Kalliopi

doi:10.1016/j.numecd.2020.08.013

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…In the Rotterdam Study of 3178 participants (57% women; mean age 72 years), Mattace-Raso et al did not find the association of alcohol consumption with cfPWV in men and women, after controlling for several known CV factors [ 35 ]. Basdeki et al also found no association among different levels of alcohol intake (> 0–10 g/day to > 30 g/day) among men ( n = 408) and women ( n = 530) (mean age across alcohol drinking groups 49–54 years) [ 32 ]. Among young adults (mean age 21 years, N = 50, 70% women), Tisdel et al reported an average of 14 g/day of alcohol (1 drink) was not associated with changes in cfPWV.…”

Section: Effects Of Alcohol Consumption On Arterial Stiffnessmentioning

confidence: 99%

“…First of all, the studies’ discrepancies may relate to both methodological and statistical issues in the assessment of alcohol consumption. Among the studies reporting no associations, Basdeki et al, Tisdel et al, and Mattace-Raso et al lacked detailed assessment of alcohol consumption (i.e., the use of standardized alcohol use questionnaire or questions) [ 32 , 34 , 35 ]. Basdeki et al also did not indicate the timeframe/duration of alcohol use assessment, which was also not always noted in other reviewed studies [ 32 ].…”

Section: Synthesis Of the Findingsmentioning

confidence: 99%

“…Among the studies reporting no associations, Basdeki et al, Tisdel et al, and Mattace-Raso et al lacked detailed assessment of alcohol consumption (i.e., the use of standardized alcohol use questionnaire or questions) [ 32 , 34 , 35 ]. Basdeki et al also did not indicate the timeframe/duration of alcohol use assessment, which was also not always noted in other reviewed studies [ 32 ]. Secondly, the definitions of levels of alcohol consumption were different among studies, making it challenging to formulate thresholds for alcohol consumption and arterial stiffness.…”

Section: Synthesis Of the Findingsmentioning

confidence: 99%

“…Several population-based and clinical cross-sectional studies have examined the association between alcohol consumption and arterial stiffness with equivocal findings. Findings include: (1) no association of arterial stiffness with different alcohol consumption amounts [32][33][34][35], (2) an inverse or J-shaped association [36][37][38][39], and (3) significant increases associated with any amount of alcohol use [40] or a binge pattern of drinking [38,41,42].…”

Section: Cross-sectional Studiesmentioning

confidence: 99%

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Alcohol Consumption: A New Risk Factor for Arterial Stiffness?

et al. 2022

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The relationship between alcohol consumption and cardiovascular disease risk is complex. Low-to-moderate daily alcohol consumption (1–2 drinks/day) is associated with reduced risk, whereas greater amounts of alcohol consumption and a “binge” pattern of drinking are associated with increased cardiovascular risk and mortality. Arterial stiffness may help explain the complex relationship. This integrated review summarizes data from studies examining the associations between alcohol consumption and pulse wave velocity, a gold standard measure of arterial stiffness. We also briefly review the concept and methodology of pulse wave velocity measurement as well as the mechanisms of alcohol-induced arterial stiffening. Findings among the different studies reviewed were inconsistent with methodological challenges related to alcohol use assessment. While making specific conclusions regarding this relationship is tenuous; the data suggest that excessive alcohol consumption or a binge drinking pattern is associated with increased arterial stiffness.

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Section: Effects Of Alcohol Consumption On Arterial Stiffnessmentioning

confidence: 99%

Section: Synthesis Of the Findingsmentioning

confidence: 99%

Section: Synthesis Of the Findingsmentioning

confidence: 99%

Section: Cross-sectional Studiesmentioning

confidence: 99%

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Alcohol Consumption: A New Risk Factor for Arterial Stiffness?

et al. 2022

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“…Studies consistently show that daily alcohol consumption is associated with higher SBP and DBP, an effect independent of factors like age, obesity, and smoking. (22,23) This relationship may be more pronounced in men, where even moderate alcohol consumption can lead to higher BP. (22) Higher educational attainment was associated with lower SBP and DBP, implying that socioeconomic factors and potentially related health behaviors could in uence BP.…”

Section: Discussionmentioning

confidence: 99%

May Measurement Month 2022: An Analysis of Blood Pressure Screening Findings from Sierra Leone

Jalloh,

Williams,

Jegede

et al. 2024

Preprint

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Introduction Elevated blood pressure, a major modifiable risk factor for death and disability globally, remains a significant public health challenge despite increased knowledge of preventive measures. Its high prevalence and underdiagnosis, particularly in low-resource settings, necessitate effective interventions. Methods The May Measurement Month (MMM) initiative by the International Society of Hypertension (ISH) aims to raise awareness and promote screening programs. This study presents the findings of the MMM 2022 in Sierra Leone. We conducted an opportunistic cross-sectional study in Sierra Leone from May to September 2022, enrolling 818 participants aged 18 or older. Results Among the participants (mean age 38.0 years, predominantly Black), the prevalence of hypertension was 25.7% (210 out 818 participants). However, only 17% (140 out of 818) of the participants were previously diagnosed with hypertension. The findings revealed a wide range of antihypertensive medication use among the known hypertensives, ranging from no medication to the use of five or more medication classes. Approximately 43.6% of the known hypertensives were taking one antihypertensive medication, while 22.9% were taking two medications. A significant proportion, 42.9%, of the known hypertensives did not consistently adhere to their antihypertensive medication regimen, citing common reasons such as cost, availability, side effects, and forgetfulness. Conclusion This study highlights the importance of community-based screening in identifying undiagnosed hypertension and emphasizes the need for expanded or alternative screening and referral programs to increase awareness, promote preventive measures, and improve hypertension management in Sierra Leone.

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Vascular Age, Metabolic Panel, Cardiovascular Risk and Inflammaging in Patients With Rheumatoid Arthritis Compared With Patients With Osteoarthritis

Rodríguez-Vargas

Santos-Moreno

Rubio-Rubio

et al. 2022

Front. Cardiovasc. Med.

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IntroductionThe risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) is 1.5–2 times higher than the general population. The fundamental risk factor for CVD is age, related to alterations at the arterial level. The aim of the study was to compare vascular age (VA) in RA patients under a strict treat-to-target (T2T) strategy with Osteoarthritis (OA) patients without strict follow up and to assess the influence of inflammaging (chronic, sterile, low-grade inflammation related to aging) and metabolic markers on VA.Materials and MethodsThis was an analytical cross-sectional study. Patients with RA (under a strict a T2T strategy) and OA patients without strict clinical follow-up were included. Patients with a history of uncontrolled hypertension, CVD, and/or current smoking were excluded. Sociodemographic, physical activity, and toxic exposure data were obtained. Waist-hip ratio and body mass index (BMI) were measured. DAS-28 (RA) and inflammatory markers, lipid profile, and glycaemia were analyzed. Pulse wave velocity (PWV) was measured (oscillometric method, Arteriograph-TensioMed®). VA was calculated based on PWV. Eleven components of inflammaging [six interleukins, three metalloproteinases (MMP), and two tissue inhibitors of metalloproteinases (TIMP)] were evaluated (Luminex® system). Univariate and bivariate analyzes (Mann Whitney U and chi-square) and correlations (Spearmans Rho) were done to compare the two groups.ResultsA total of 106 patients (74% women) were included, 52/RA and 54/OA. The mean age was 57 (Interquartile range - IQR 9 years). The BMI, waist circumference, and weight were higher in patients with OA (p < 0.001). RA patients had low disease activity (DAS-28-CRP). There were no differences in VA, inflammaging nor in PWV between the two groups. VA had a positive, but weak correlation, with age and LDL. In group of RA, VA was higher in those who did not receive methotrexate (p = 0.013). LDL levels correlated with MMP1, TIMP1, and TIMP2.ConclusionsWhen comparing RA patients with low levels of disease activity with OA patients with poor metabolic control, there are no differences in VA. Furthermore, methotrexate also influences VA in RA patients. This shows that implemented therapies may have an impact on not only the inflammatory state of the joint but also CVD risk.

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Moderately increased alcohol consumption is associated with higher pressure wave reflections and blood pressure in men

Cited by 4 publications

References 17 publications

Alcohol Consumption: A New Risk Factor for Arterial Stiffness?

Alcohol Consumption: A New Risk Factor for Arterial Stiffness?

May Measurement Month 2022: An Analysis of Blood Pressure Screening Findings from Sierra Leone

Vascular Age, Metabolic Panel, Cardiovascular Risk and Inflammaging in Patients With Rheumatoid Arthritis Compared With Patients With Osteoarthritis

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