Moderate Versus Deep Hypothermia for Arterial Switch Operation

Abstract

ASO can be safely performed using moderate hypothermia, even with complex anatomy, leading to comparatively good results compared to a conventional approach.

Systematic Review and Meta‐Analysis of benefits and risks between normothermia and hypothermia during cardiopulmonary bypass in pediatric cardiac surgery

“…Stocker concluded that the temperature has little effect on the systemic inflammatory response syndrome and organ injury after pediatric cardiac surgery. This conclusion is further supported by retrospective studies which confirming the feasibility, safety, and potential clinical advantages of normothermic CPB compared with hypothermic CPB in pediatric cardiac surgery.…”

Outcome of inflammatory response after normothermia during cardiopulmonary bypass surgery in infants with isolated ventricular septal defect

“…Medical treatment includes corticosteroids. In the several adult studies, hypothermia during the surgery is known to protect major organs from ischemic injury by reducing the oxygen consumption, the complement activation, and whole body inflammatory response to CPB11,12,13).…”

The influence of bypass temperature on the systemic inflammatory response and organ injury after pediatric open surgery: A randomized trial

“…This study has addressed an important and previously unresolved clinical question regarding the most appropriate temperature during pediatric CPB. 2,[7][8][9] Although moderate hypothermia at 28 C has been shown to offer better protection from postoperative SIRS than normothermia (37 C) during CPB in the experimental setting, this has never been shown to translate into improved outcomes in the clinical setting. 10,11 Thus, following the precedent…”

“…This conclusion is further supported by 3 large retrospective studies confirming the feasibility, safety, and potential clinical advantages of warmer CPB temperature when compared with cooler CPB temperature in pediatric cardiac surgery. 8,9,19…”