Moderate selenium dosing inhibited chromium (VI) toxicity in chicken liver

Abstract

This study aimed to clarify the effect of selenium (Se) on chromium (VI) [Cr(VI)]-induced damage in chicken liver. A total of 105 chickens were randomly divided into seven groups of 15. Group I received deionized water; group II received Cr(VI) (7.83 mg/kg/d) alone; and other groups orally received both Cr(VI) (7.83 mg/kg/d) and Se of different doses (0.14, 0.29, 0.57, 1.14, and 2.28 mg/kg/d). The levels of superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), Ca -ATPase, and mitochondrial membrane potential (MMP) were measured. Results showed that Cr(VI) increased MDA content and decreased GSH content, T-SOD activity, Ca -ATPase activity, and MMP level. Meanwhile, Se co-treatment (0.14, 0.29, and 0.57 mg/kg/d) increased the viability of the above indicators compared with Cr(VI)-treatment alone. In addition, histopathologic examination revealed that Cr(VI) can cause liver damage, whereas Se supplementation of moderate dose inhibited this damage. This study confirmed that Se exerted protective effect against Cr(VI)-induced liver damage.

Protective effects of selenized yeast on the combination of cadmium-, lead-, mercury-, and chromium-induced toxicity in laying hens

“…Our data suggested that Se as selenized yeast showed an ameliorative effect on oxidative damage in the serum, liver, and ovary by decreasing MDA or ROS and partly decreasing the activity of antioxidant enzymes. Previous reports have revealed that adequate doses of organic or inorganic Se can eliminate hydrogen peroxide (H 2 O 2 ), lipid, and phospholipid hydroperoxides and protect tissues such as liver, kidneys, brain, and reproductive organs from individual Cd, Pb, Cr, and Hg-induced or combined Pb and Cd-induced oxidative damage ( 32 – 35 , 38 ), which are consistent with the work reported herein. Other possible reasons were that SeMet inhibits HEM-induced stress.…”

“…In addition, diphenyl diselenide [(PhSe) 2 ] decreases methylmercury-induced cerebral, hepatic, and renal oxidative stress and Hg deposition in adult mice ( 36 ). It has been reported that Se administration alleviates Cr toxicity in the chicken brain and liver ( 37 , 38 ).…”

Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilers

“…The liver plays an indispensable metabolite filtration role, protecting the body from heavy metal toxicity ( Reinke and Asher, 2016 ; Davies et al, 2020 ). However, a large number of heavy metals including Cd ( Cong et al, 2019 ), As ( Ren et al, 2021 ), copper ( Sharaf et al, 2021 ), Pb ( Amin et al, 2021 ), and Cr(Ⅵ) ( Wang et al, 2017 ), can accumulate in the liver and destroy its structure and function in several species. Currently, Cr(Ⅵ) dissemination into the environment is largely caused by its wide use in different industrial production and processing applications ( Balmer, 2018 ; Jobby et al, 2018 ).…”

Effects of embryonic exposure to chromium (VI) on blood parameters and liver microstructure of 1-day-old chickens

“…According to Hamilton and Wetterhahn (1986) , Cr(VI) caused DNA damage in the liver and blood cells of chick embryos. It was also demonstrated that excessive exposure to Cr(VI) can lead to pathophysiological and histopathological changes in the liver of chicks ( Wang et al., 2017 , 2020 ; Zhao et al., 2019 ). The median lethal dose (LD 50 ) of hexavalent chromium was estimated as 50 to 150 mg/kg in mammals ( Katz and Salem, 1993 ) and 164 mg per kg body weight in broilers ( Zhao et al., 2019 ).…”