Moderate Intensity Static Magnetic Fields Prevent Thrombus Formation in Rats and Mice

Li, Qin; Liao, Zhongcai; Gu, Leyi; Zhang, Lei; Zhang, Lingxi; Tian, Xiaofei; Li, Jun; Fang, Zhicai; Zhang, Xinyue

doi:10.1002/bem.22232

“…Using the magnet therapy has been considered since ancient times 1 . Due to the change of magnetic field with time, the magnetic field is divided into two categories, static and dynamic magnetic fields 2 .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles

Moghanizadeh

¹

,

Ashrafizadeh

²

,

Varshosaz

³

et al. 2021

Sci Rep

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Employing the magnets in therapy has a long history of treating diseases, and currently new applications such as drug delivery by magnetic nanoparticles are gaining more attention. This research tried to study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles carrying thrombolytic agents. In this research, Fe3O4@SiO2 nanoparticles carrying streptokinase were applied. The efficiency of thrombolysis and micro-CT-scan images are utilized to study the effect of different magnetic fields (0.1, 0.2, 0.3 and 0.5 T) on thrombolysis. The results confirm that increasing the static magnetic field intensity accelerated the thrombolysis. Increasing the intensity of the magnetic field from 0.1 to 0.3 T leads to an increase in clot dissolution rate from 55 to 89%, respectively. Moreover, micro-CT-scan images revealed that magnetic nanoparticles carrying a thrombolytic agent penetrated deeper into the mesh-like structure of clot as the magnetic field intensities increased, which could lead to further dissolution of the clot.

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“…Thus, magnetically hindered thrombosis with FeCl 3 will require a greater concentration of FeCl 3 compared with its application with no magnetic field. The effects of an MF on FeCl 3 -induced thrombosis were studied in rat model experiments [ 68 ]. In the group of rats exposed to a static 600 mT magnetic field thrombus protein content (0.28 ± 0.14 mg/mL) was downregulated compared with the model control group (0.47 ± 0.10 mg/mL).…”

Section: Resultsmentioning

confidence: 99%

Effects of High Magnetic Fields on the Diffusion of Biologically Active Molecules

Zablotskii

¹

,

Polyakova

²

,

Dejneka

³

2021

Cells

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The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species including oxygen, hemoglobin, and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of an MF as well as reveal the underlying mechanism of the MF’s effect on diffusion. We found that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that an MF may significantly alter the gas exchange in an erythrocyte and cause swelling. Our prediction that the diffusion rate and characteristic time can be controlled by an MF opens new avenues for experimental studies foreseeing numerous biomedical applications.

show abstract

“…Thus, magnetically hindered thrombosis with FeCl 3 will require a greater concentration of FeCl 3 compared with its application with no magnetic field. The effects of MF on the FeCl 3 -induced thrombosis were studied in rat model experiments [67]. In the group of rats exposed to a static 600-mT magnetic field thrombus protein content (0.28 ± 0.14 mg/ml) was downregulated compared with the model control group (0.47 ± 0.10 mg/ml).…”

Section: Resultsmentioning

confidence: 99%

Effects of High Magnetic Fields on Diffusion of Biologically Active Molecules

Zablotskii

¹

,

Polyakova

²

,

Dejneka

³

2020

Preprint

0

View full text Add to dashboard Cite

The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species, including oxygen, hemoglobin, ROS and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of a MF as well as reveal the underlying mechanism of the MF effect on diffusion. We find that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that a MF may significantly alter the gas exchange in an erythrocyte and cause swelling. Our prediction that the diffusion rate and characteristic time can be controlled by a MF opens new avenues for experimental studies foreseeing numerous biomedical applications.SignificanceWe show that diffusion processes of biologically active molecules (hemoglobin, oxygen, reactive oxygen species, etc.) and paramagnetic drugs can be remotely controlled by high static magnetic fields. Since diffusion processes determine the reference time scale for all other processes in living cells as well as the propagation speed of signaling molecules during cell-to-cell communication, our results – the magnetic field dependences of the diffusion rate and characteristic time – may serve as an important key for revealing and understanding the mechanisms of magnetic field action on living cells, tissue and organisms.

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Moderate Intensity Static Magnetic Fields Prevent Thrombus Formation in Rats and Mice

Cited by 14 publications

References 35 publications

RETRACTED ARTICLE: Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles

RETRACTED ARTICLE: Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles

Effects of High Magnetic Fields on the Diffusion of Biologically Active Molecules

Effects of High Magnetic Fields on Diffusion of Biologically Active Molecules

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