RETRACTED ARTICLE: Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles

Abstract

Employing the magnets in therapy has a long history of treating diseases, and currently new applications such as drug delivery by magnetic nanoparticles are gaining more attention. This research tried to study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles carrying thrombolytic agents. In this research, Fe3O4@SiO2 nanoparticles carrying streptokinase were applied. The efficiency of thrombolysis and micro-CT-scan images are utilized to study the effect of different magnetic fields (0.1, 0.2, 0.3 and 0.5 T) on thrombolysis. The results confirm that increasing the static magnetic field intensity accelerated the thrombolysis. Increasing the intensity of the magnetic field from 0.1 to 0.3 T leads to an increase in clot dissolution rate from 55 to 89%, respectively. Moreover, micro-CT-scan images revealed that magnetic nanoparticles carrying a thrombolytic agent penetrated deeper into the mesh-like structure of clot as the magnetic field intensities increased, which could lead to further dissolution of the clot.

Retraction Note: Noninvasive thrombectomy of graft by nano-magnetic ablating particles

“…VSM data for zinc ferrite in Figure 4B appear to be identical with the Fe 3 O 4 VSM data in Figure 2B in 1 .…”

“…the TEM image of zinc ferrite in Figure 3 appear to be identical with the TEM image of Fe 3 O 4 nanoparticles in Figure 1 in 1 ;…”

“…After publication of this Article it was brought to the Editors' attention that some of the data appear to overlap with those in another article from these authors 1 . Specifically: the TEM image of zinc ferrite in Figure 3 appear to be identical with the TEM image of Fe 3 O 4 nanoparticles in Figure 1 in 1 ; VSM data for zinc ferrite in Figure 4B appear to be identical with the Fe 3 O 4 VSM data in Figure 2B in 1 . …”

On-Demand Drug Delivery: Recent Advances in Cardiovascular Applications

“…In line with this, Moghanizadeh et al developed iron oxide nanoparticles with silica shell, that were loaded with streptokinase. These particles were subsequently used in vitro to test the influence of magnetic field intensity on clot dissolution speed, showing that thrombolysis rate increases with the growing intensity of static magnetic field, and that deeper clot penetration is possible using these nanocarriers (Moghanizadeh et al, 2021).…”

l-Asparagine–EDTA–amide silica-coated MNPs: a highly efficient and nano-ordered multifunctional core–shell organocatalyst for green synthesis of 3,4-dihydropyrimidin-2(1H)-one compounds

“…[1][2][3][4][5][6][7][8] In this regard, heterogeneous catalytic systems and their magnetic nanoparticle (MNP) counterparts have received considerable interest because of their unique properties. [9][10][11] The outstanding properties of MNPs have made them superior and indispensable in many areas of academia and industry including information storage, 12 medicine, 13 drug delivery, 14 magnetic resonance imaging (MRI), [15][16][17] biomedical applications, 10,18,19 and environmental remediation 20 as well as heterogeneous catalysis. [21][22][23][24] In academia, MNPs represent a promising new tool for performing chemical reactions because they are separated from the reaction medium, comfortably.…”