Moderate Fetal Alcohol Exposure Impairs the Neurogenic Response to an Enriched Environment in Adult Mice

Choi, Irene; Allan, Andrea M.; Cunningham, Lee Anna

doi:10.1097/01.alc.0000187037.02670.59

Cited by 78 publications

(94 citation statements)

References 56 publications

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“…The direction and magnitude of changes in neurogenesis in models of foetal alcohol spectrum disorders depend on several factors, including blood alcohol concentration attained, frequency of exposure and phase of gestation during which alcohol is administered [40]. In agreement with our findings, some studies have reported no significant changes on proliferation and survival of neuronal precursors following exposure to alcohol throughout the pregnancy [41,42], but others have after similarly long exposure [17]. Further, a study in females revealed no effects of prenatal alcohol exposure on hippocampal cytogenesis and survival [43].…”

Section: Discussionsupporting

confidence: 89%

Prenatal Exposure to Alcohol and 3,4-Methylenedioxymethamphetamine (Ecstasy) Alters Adult Hippocampal Neurogenesis and Causes Enduring Memory Deficits

Canales

Ferrer-Donato²

2014

Dev Neurosci

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Recreational drug use among pregnant women is a source of concern due to potential harmful effects of drug exposure on prenatal and infant development. The simultaneous abuse of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] and alcohol is prevalent among young adults, including young expectant mothers. Here, we used a rat model to study the potential risks associated with exposure to alcohol and MDMA during pregnancy. Pregnant rats received alcohol, MDMA, or both alcohol and MDMA by gavage at E13 through E15 twice daily. Female offspring treated prenatally with the combination of alcohol and MDMA, but not those exposed to either drug separately, showed at 3 months of age decreased exploratory activity and impaired working memory function. Prenatal treatment with the combination of alcohol and MDMA decreased proliferation of neuronal precursors in the adult dentate gyrus of the hippocampus, as measured by 5-bromo-2-deoxyuridine labelling, and adult neurogenesis, assessed by quantifying doublecortin expression. These results provide the first evidence that the simultaneous abuse of alcohol and ecstasy during pregnancy, even for short periods of time, may cause significant abnormalities in neurocognitive development.

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Section: Discussionsupporting

confidence: 89%

Prenatal Exposure to Alcohol and 3,4-Methylenedioxymethamphetamine (Ecstasy) Alters Adult Hippocampal Neurogenesis and Causes Enduring Memory Deficits

Canales

Ferrer-Donato²

2014

Dev Neurosci

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“…Wainwright et al (1993) reported that alcohol-exposed animals in an enriched environmental condition performed better on the Morris Water Maze task than those placed in an isolated environmental condition. In contrast, Choi et al (2005) found an interaction between environmental condition and exposure history in a mouse model. That is, while control mice placed in the enriched environment showed a two-fold increase in hippocampal neurogenesis, alcohol-exposed mice placed in the enriched environment did not demonstrate such a neurogenic response.…”

Section: Environmental Enrichmentmentioning

confidence: 77%

“…A number of investigators have evaluated the effectiveness of postnatal enriched experiences at mitigating alcohol-induced behavioral and learning deficits in rodent models (Choi et al 2005;Hannigan et al 1993;Mothes et al 1996;Wainwright, et al 1993). Hannigan et al (1993) found that placement of alcohol-exposed rats in socially and physically enriched environments reduced alcoholinduced motor and learning deficits.…”

Section: Environmental Enrichmentmentioning

confidence: 99%

From Research to Practice: An Integrative Framework for the Development of Interventions for Children with Fetal Alcohol Spectrum Disorders

Kodituwakku

2011

Neuropsychol Rev

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Since fetal alcohol syndrome was first described over 35 years ago, considerable progress has been made in the delineation of the neurocognitive profile in children with prenatal alcohol exposure. Preclinical investigators have made impressive strides in elucidating the mechanisms of alcohol teratogenesis and in testing the effectiveness of pharmacological agents and dietary supplementation in the amelioration of alcohol-induced deficits. Despite these advances, only limited progress has been made in the development of evidence-based comprehensive interventions for functional impairment in alcohol-exposed children. Having performed a search in PubMed and PsycINFO using key words, interventions, treatment, fetal alcohol syndrome, prenatal alcohol exposure, and fetal alcohol spectrum disorders, we found only 12 papers on empirically-based interventions. Only two of these interventions had been replicated and none met the criteria of "well-established," as defined by Chambless and Hollon (Journal of Consulting and Clinical Psychology 66(1):7-18, 1998). There has been only limited cross-fertilization of ideas between preclinical and clinical research with regard to the development of interventions. Therefore, we propose a framework that allows integrating data from preclinical and clinical investigations to develop comprehensive intervention programs for children with fetal alcohol spectrum disorders. This framework underscores the importance of multi-level evaluations and interventions.

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“…Damage in the CNS has been widely reported in FAS studies in both humans and animals. Impaired functioning of the neurons has been noted in many studies (Choi et al, 2005). In the present study, the effect of prenatal alcohol exposure on spinal motoneurons was investigated.…”

Section: Discussionmentioning

confidence: 87%

The effects of prenatal alcohol exposure on the morphological characteristics of spinal motoneurons

David

Krishnan

2009

Birth Defects Research

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Moderate Fetal Alcohol Exposure Impairs the Neurogenic Response to an Enriched Environment in Adult Mice

Abstract: These observations indicate that moderate FAE results in a long-term, persistent defect in neurogenic responses to behavioral challenge.

Cited by 78 publications

References 56 publications

Prenatal Exposure to Alcohol and 3,4-Methylenedioxymethamphetamine (Ecstasy) Alters Adult Hippocampal Neurogenesis and Causes Enduring Memory Deficits

Prenatal Exposure to Alcohol and 3,4-Methylenedioxymethamphetamine (Ecstasy) Alters Adult Hippocampal Neurogenesis and Causes Enduring Memory Deficits

From Research to Practice: An Integrative Framework for the Development of Interventions for Children with Fetal Alcohol Spectrum Disorders

The effects of prenatal alcohol exposure on the morphological characteristics of spinal motoneurons

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