The effects of prenatal alcohol exposure on the morphological characteristics of spinal motoneurons

David, Pamela; Krishnan, Seetha

doi:10.1002/bdra.20593

Cited by 6 publications

(1 citation statement)

References 37 publications

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“…A study on prenatal alcohol intake has shown that the number and the morphology of MN were significantly reduced. The authors highlighted the detrimental effects of EtOH (neurotoxicity and oxidative stress) in this critical period of the development of the nervous system [63].…”

Section: Discussionmentioning

confidence: 99%

Aerobic Physical Training Attenuates Oxidative Stress in the Spinal Cord of Adult Rats Induced by Binge-like Ethanol Intake

et al. 2023

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Binge drinking is the most frequent consumption pattern among young adults and remarkably changes the central nervous system; thus, research on strategies to protect it is relevant. This study aimed to investigate the detrimental effects of binge-like EtOH intake on the spinal cord of male rats and the potential neuroprotective effects provided by moderate-intensity aerobic physical training. Male Wistar rats were distributed into the ‘control group’, ‘training group’, ‘EtOH group’, and ‘training + EtOH’. The physical training protocol consisted of daily 30-min exercise on a treadmill for 5 consecutive days followed by 2 days off during 4 weeks. After the fifth day of each week, distilled water (‘control group’ and ‘training group’) or 3 g/kg of EtOH diluted at 20% w/v (‘EtOH group’ and ‘training + EtOH group’) was administered for 3 consecutive days through intragastric gavage to simulate compulsive consumption. Spinal cord samples were collected for oxidative biochemistry and morphometric analyses. The binge-like EtOH intake induced oxidative and tissue damage by decreasing reduced glutathione (GSH) levels, increasing lipid peroxidation (LPO), and reducing motor neurons (MN) density in the cervical segment. Even under EtOH exposure, physical training maintained GSH levels, reduced LPO, and prevented MN reduction at the cervical segment. Physical training is a non-pharmacological strategy to neuroprotect the spinal cord against oxidative damage induced by binge-like EtOH intake.

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Section: Discussionmentioning

confidence: 99%

Aerobic Physical Training Attenuates Oxidative Stress in the Spinal Cord of Adult Rats Induced by Binge-like Ethanol Intake

et al. 2023

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Prenatal alcohol–induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine

et al. 2017

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Neuroprotective peptides influence cytokine and chemokine alterations in a model of fetal alcohol syndrome

Roberson

Kuddo

Benassou

et al. 2012

American Journal of Obstetrics and Gynecology

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The effects of prenatal alcohol exposure on the morphological characteristics of spinal motoneurons

Abstract: Prenatal exposure to alcohol showed cytotoxic effects whereby it adversely affected both motoneuron growth and differentiation in utero.

Cited by 6 publications

References 37 publications

Aerobic Physical Training Attenuates Oxidative Stress in the Spinal Cord of Adult Rats Induced by Binge-like Ethanol Intake

Aerobic Physical Training Attenuates Oxidative Stress in the Spinal Cord of Adult Rats Induced by Binge-like Ethanol Intake

Prenatal alcohol–induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine

Neuroprotective peptides influence cytokine and chemokine alterations in a model of fetal alcohol syndrome

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