Moderate Exercise Does Not Reverse Adverse Effects Of Stress On Cutaneous Wound Healing

Monte‐Alto‐Costa, Andréa; Saguie, Bianca Oliveira; Romana‐Souza, Bruna

doi:10.1096/fasebj.29.1_supplement.876.1

Cited by 1 publication

(2 citation statements)

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“…Glucocorticoid, through reducing the expression of inflammatory mediators and chemokines by inhibition of migration of inflammatory cells to the wound area impair wound healing (15). Glucocorticoids, as anti-inflammatory agents, suppress immune cells, modulate Th1-mediated immune responses, and delay the healing process as a result of increasing the duration of the inflammatory phase (26). Topical application of glucocorticoids stimulates the production of inflammatory cytokines and inhibits keratinocyte growth factor (KGF) expression (27).…”

Section: Negative Factors On Wound Healing 471 Medicationmentioning

confidence: 99%

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Reviewing the Physiology of Cutaneous Wound Healing and Evaluating the Effect of Exercise on It: A Narrative Review Article

Riyahi

Riahy

Yousefpour

2021

Ann Mil Health Sci Res

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Context: The skin is the most important organ of the body, and maintaining its integrity is important for health. Severe skin damage is life-threatening, and wound healing restores its integrity. One of the main health problems is impaired cutaneous wound healing. According to the importance of wound healing and the fact that unrepaired skin decreases the quality of life, many studies have investigated the effect of some natural and chemical substances on the length and quality of wound healing to find beneficial interventions for rapid and economical treatment. Objectives: This review was conducted to describe the physiology of cutaneous wound healing and some positive and negative factors affecting it with a focus on exercise. Methods: An electronic search without any time limitation was performed on the PubMed, Google Scholar, and Web of Science databases. The keywords were ‘wound’, ‘healing’, and ‘exercise’. Finally, according to the similarities or differences between the results and the relationship with the subject, 53 papers were selected and reviewed. Results: Wound healing is a complex physiological process with four overlapping processes. It seems that disturbance in the inflammatory phase of wound healing is the main factor in the impairment of healing. Traditionally, many chemical and herbal medicines and compounds have been used to speed up wound recovery due to their anti-inflammatory and antioxidative properties. Many studies have evaluated the effect of exercise, as complementary medicine, on wound healing, and they have examined the effect of different protocols of exercise on the speed of wound healing. According to the results of these studies, aerobic exercise, due to its anti-inflammatory and antioxidative effects, is a beneficial method in shortening the length of healing, especially in aged, obese, and diabetic individuals. Conclusions: Exercise as a low-cost intervention is a good strategy in the treatment of impaired and chronic wounds.

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Section: Negative Factors On Wound Healing 471 Medicationmentioning

confidence: 99%

“…Stress increases inflammatory cells and decreases angiogenesis and differentiation of the fibroblast to myofibroblast and low matrix deposition in the wound (30). Another mechanism through which stress delays wound healing is the reduction in collagen synthesis (26).…”

Section: Biological Situationsmentioning

confidence: 99%