“…10 Specifically, very short telomere length in 3 or 4 of total lymphocytes, naïve T cells, memory T cells, and B cell subsets, as determined by Flow-FISH, is both highly sensitive and specific for DC. Whereas some patients have profoundly short telomeres, others may have telomere lengths that hover around the first percentile, as did the proband in Guo et al 1 Additionally, telomere length slightly below the first percentile across lymphocyte populations has been observed, albeit rarely, in patients with inherited bone marrow failure syndromes other than DC, such as Fanconi anemia, Diamond-Blackfan anemia, and Shwachman-Diamond syndrome.…”