Cyclophosphamide in severe aplastic anemia?

Latour, Régis Peffault de

doi:10.1182/blood-2014-09-600205

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…These miRNAs may influence the behavior of targeted cells and have both been linked to numerous human diseases [85]. Proteomic analysis of platelet exosomes revealed the presence of HSP70, GPIb, GPV, and WNT glycoproteins which regulate WNT signaling in monocytes and endothelial cells [86]. Interestingly, exosomes released from platelets stimulated with thrombin and collagen present an increased amount of chemokines CXCL4, CXCL7, and cytoplasmic high-mobility group box 1 (HMGB1) protein, which contribute to the pathogenesis of atherosclerosis [87] (Table 2).…”

Section: Circulating Evsmentioning

confidence: 99%

Biology and Role of Extracellular Vesicles (EVs) in the Pathogenesis of Thrombosis

Zara

Guidetti

Camera

et al. 2019

IJMS

126

111

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Extracellular vesicles (EVs) are well-established mediators of cell-to-cell communication. EVs can be released by every cell type and they can be classified into three major groups according to their biogenesis, dimension, density, and predominant protein markers: exosomes, microvesicles, and apoptotic bodies. During their formation, EVs associate with specific cargo from their parental cell that can include RNAs, free fatty acids, surface receptors, and proteins. The biological function of EVs is to maintain cellular and tissue homeostasis by transferring critical biological cargos to distal or neighboring recipient cells. On the other hand, their role in intercellular communication may also contribute to the pathogenesis of several diseases, including thrombosis. More recently, their physiological and biochemical properties have suggested their use as a therapeutic tool in tissue regeneration as well as a novel option for drug delivery. In this review, we will summarize the impact of EVs released from blood and vascular cells in arterial and venous thrombosis, describing the mechanisms by which EVs affect thrombosis and their potential clinical applications.

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Section: Circulating Evsmentioning

confidence: 99%