Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

D'Costa, Anselm P.; Lenham, John E.; Ingram, Rhonda L.; Sonntag, William E.

doi:10.1016/0047-6374(93)90035-p

Cited by 54 publications

(23 citation statements)

References 28 publications

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“…Caloric restriction has been demonstrated to extend normal life span and improve health in many animal studies [1, 2, 42]. Animals show reduction in IGF-I and insulin levels as well as an increase in the sensitivity to insulin and IGF-I during limited caloric intake [1, 2, 42].…”

Section: Discussionmentioning

confidence: 99%

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring

Vitale

Brugts

Ogliari

et al. 2012

Aging

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Centenarians’ offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians’ offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians’ offspring. IGF-I bioactivity (p<0.01), total IGF-I (p<0.01) and the IGF-I/IGFBP-3 molar ratio (p<0.001) were significantly lower in centenarians’ offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians’ offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians’ offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians’ offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.

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Section: Discussionmentioning

confidence: 99%

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring

Vitale

Brugts

Ogliari

et al. 2012

Aging

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show abstract

“…CR animals have greater sensitivity to insulin without a change in muscle insulin receptors [88] while the sensitivity gain to a variety of other growth factors in CR animals is due to the combination of higher mem brane fluidity and higher levels of receptors (e.g. IGF-1) [89,90] that are the typical re sponse to lower hormone levels. Comparison of ad libitum and calorie-restricted hormonal/growth factor exposure over life course.…”

Section: Hormonal Imbalance and Growth Factor Exposure Theorymentioning

confidence: 99%

Insulin Exposure and Aging Theory

Parr¹

1997

Gerontology

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The underlying mechanism of calorie restriction (CR) extension of mammalian life spans operates by altering the rate of decline in reserve capacity (with time) as well as the exposure to growth stimulus, two mechanisms that seem to be related to the central genetically determined mechanism that controls mammalian life span over a 50-fold range. While genetic control is principally exerted at the level of metabolic rate and entrained protective defenses, CR appears to alter the rate of decline in reserve capacity and the exposure to growth stimulus without appreciable alteration of metabolic rate. CR accomplishes this by lowering the nutritionally driven level of insulin exposure, which in turn lowers overall growth factor exposure, improves age-declining maintenance of mitochondrial maximal function, and maintains a longer-term favorable balance of the insulimgrowth hormone antagonism. Obtaining the ‘halved’ insulin exposure in calorie-restricted animals (relative to ad libitum fed) can be specifically targeted in non-obese ad libitum fed humans by multiple techniques, a situation that may confer most of the life span extension of CR without restricting calories. The prospect for even further extension of the human life span is considered.

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“…In rodents, caloric restriction reduces insulin levels (Masoro et al, 1992) and IGF-1 levels (Breese et al, 1991; D’Costa et al, 1993), increases corticosterone levels (Sabatino et al, 1991), and decreases serum thyroid hormone levels (Herlihy et al, 1990). The effects on thyroid hormone, which regulates metabolic rate, would seem to suggest that a reduction in metabolic rate could be involved in extending lifespan, but energy expenditure in calorically restricted rats was found to be higher than expected based on body composition (Selman et al, 2005).…”

Section: Conserved Roles Of Endocrine Signaling In Longevity Regulationmentioning

confidence: 99%

Comparative Endocrinology of Aging and Longevity Regulation

Allard¹,

Duan²

2011

Front. Endocrin.

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Hormones regulate growth, development, metabolism, and other complex processes in multicellular animals. For many years it has been suggested that hormones may also influence the rate of the aging process. Aging is a multifactorial process that causes biological systems to break down and cease to function in adult organisms as time passes, eventually leading to death. The exact underlying causes of the aging process remain a topic for debate, and clues that may shed light on these causes are eagerly sought after. In the last two decades, gene mutations that result in delayed aging and extended longevity have been discovered, and many of the affected genes have been components of endocrine signaling pathways. In this review we summarize the current knowledge on the roles of endocrine signaling in the regulation of aging and longevity in various animals. We begin by discussing the notion that conserved systems, including endocrine signaling pathways, “regulate” the aging process. Findings from the major model organisms: worms, flies, and rodents, are then outlined. Unique lessons from studies of non-traditional models: bees, salmon, and naked mole rats, are also discussed. Finally, we summarize the endocrinology of aging in humans, including changes in hormone levels with age, and the involvement of hormones in aging-related diseases. The most well studied and widely conserved endocrine pathway that affects aging is the insulin/insulin-like growth factor system. Mutations in genes of this pathway increase the lifespan of worms, flies, and mice. Population genetic evidence also suggests this pathway’s involvement in human aging. Other hormones including steroids have been linked to aging only in a subset of the models studied. Because of the value of comparative studies, it is suggested that the aging field could benefit from adoption of additional model organisms.

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Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

Cited by 54 publications

References 28 publications

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring

Insulin Exposure and Aging Theory

Comparative Endocrinology of Aging and Longevity Regulation

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