2012
DOI: 10.18632/aging.100484
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Centenarians’ offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians’ offspring and 80 offspring-controls of which both parents d… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

6
43
0

Year Published

2013
2013
2014
2014

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 67 publications
(49 citation statements)
references
References 35 publications
(55 reference statements)
6
43
0
Order By: Relevance
“…4). Levels of IGF-1, a marker associated with accelerated aging, [73][74][75] tended to be increased in p53 −/− mice, reaching a statistical significance after radiation (Fig. 4F).…”
Section: Resultsmentioning
confidence: 90%
“…4). Levels of IGF-1, a marker associated with accelerated aging, [73][74][75] tended to be increased in p53 −/− mice, reaching a statistical significance after radiation (Fig. 4F).…”
Section: Resultsmentioning
confidence: 90%
“…Moreover, in healthy non-obese humans, activation of D 2 R has also been shown to affect circulating GH and consequently IGF-I levels [85]. Taking into account that IGF-I bioactivity has been found inversely associated to insulin sensitivity [86], the decrease in GH levels and/or in IGF-I bioactivity could represent another potential mechanism involved in insulin sensitivity amelioration. A significant improvement in glucose metabolism and insulin resistance after 6 months of treatment with BRC or CAB has been described in patients with prolactinomas [46,47].…”
Section: Discussionmentioning
confidence: 99%
“…[15][16][17][18][19][20][21] Fourth, emerging evidence suggests a positive influence of diminished GH/IGF-I axis on longevity (via improved cancer and diabetes related outcomes). [22][23][24] Whether this is partially mediated by the influence of sleep architecture and sleep disordered breathing on the GH/IGF-I axis is unknown.…”
Section: Sleep and Insulin-like Growth Factors In The Cardiovascularmentioning
confidence: 99%