Giovanni Vitale, Michael P Brugts, Giulia Ogliari, Davide Castaldi, Letizia M. Fatti, Aimee J. Varewijck, Steven W. Lamberts, Daniela Monti, Laura Bucci, Elisa Cevenini, Francesco Cavagnini, Claudio Franceschi, Leo J Hofland, Daniela Mari et al.
Abstract:Centenarians’ offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians’ offspring and 80 offspring-controls of which both parents d…
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