Moderate Alcohol During Pregnancy: Learning and Behavior in Adolescent Rhesus Monkeys

Schneider, Mary L.; Moore, Colleen F.; Kraemer, Gary W.

doi:10.1111/j.1530-0277.2001.tb02362.x

Cited by 57 publications

(42 citation statements)

References 61 publications

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“…10 Cognitive deficits have been found in FAE animal models using both spatial [11][12][13][14] and nonspatial tasks. [15][16][17][18] Furthermore, similar to findings in humans, previous results from our laboratory indicate that both male and female adult FAE offspring exhibit increased depressive-like behavior in the forced swim test (FST) compared to pair-fed controls. 19 Originally described by Porsolt et al, 20 the FST is the bestcharacterized and most widely used model for assessing alterations in depression-or antidepressant-related behavior in rodents following genetic or drug-induced manipulations.…”

supporting

confidence: 80%

Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE

et al. 2005

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Children prenatally exposed to alcohol typically exhibit behavioral abnormalities, including hyperactivity, learning deficits, and an increased prevalence of depression. Similar impairments are found in children of hypothyroid mothers, and we have shown that alcohol-consuming rat dams have suppressed hypothalamic-pituitary-thyroid (HPT) function. Therefore, we hypothesized that suppressed maternal thyroid hormonal milieu may contribute to the deleterious consequences of prenatal alcohol exposure. We aimed first to confirm and then to reverse the behavioral deficits in the fetal alcohol exposed (FAE) rat offspring by administration of thyroxine (T4) to the alcohol-consuming dams. Adult offspring prenatally exposed to ethanol (FAE; 35% ethanol-derived calories), pair-fed (PF) or control (C) diets were tested in the Morris water maze (MWM), the forced swim test (FST), and the open field test (OFT) to assess spatial learning, depressive behavior, and exploratory behavior/anxiety, respectively. Adult FAE offspring took longer to locate a hidden platform in the MWM and showed increased depressive behavior in the FST both of which were reversed by administration of T4 to the alcohol-consuming mother. We found sex and brain regionspecific alterations in expression of genes involved in these behaviors in FAE adult offspring. Specifically, decreased hippocampal GAP-43 mRNA levels in adult FAE females and decreased glucocorticoid receptor (GR) expression in the amygdala of male and female FAE offspring were observed. The decreased mRNA levels of GAP-43 and GR were normalized by T4 treatment to the alcohol-consuming mother. Our results suggest that the suppressed HPT function of the alcohol-consuming mother contributes to the behavioral and cognitive dysfunctions observed in the offspring. Prenatal alcohol exposure has long-term developmental consequences, 1-3 and in humans alcohol is recognized as a teratogen leading to long-lasting CNS dysfunctions. 4 Specifically, patients with fetal alcohol exposure (FAE) have marked cognitive deficits, including difficulty focusing and sustaining attention, 5 and place learning deficits in a virtual Morris water task. 6 Attention deficit hyperactivity disorder (ADHD) is frequently diagnosed in FAE children. These neurocognitive and behavioral characteristics differ between FAE children and those with a primary diagnosis of ADHD, as FAE children have difficulties primarily in the encoding and retrieval of information. 7 A significantly increased prevalence of depression is also found in children 8 and adults 9 prenatally exposed to alcohol. It is important to note that, in contrast to the higher female prevalence of depressive disorders in the general population, the rate of depression found in adults with prenatal alcohol exposure was nearly equal among men and women. 9 Fetal alcohol effects qualitatively similar to those described in children with a history of gestational alcohol exposure have been detected with animal models. 10 Cognitive deficits have been found in FAE animal models...

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supporting

confidence: 80%

Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE

et al. 2005

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“…As further support for this adaptation, Schneider et al (2001b) found that prenatal alcohol exposure in nonhuman primates leads to difficulty in the early learning phase, when contingencies first shift away from a prepotent choice of object. The competency assessment for the modified TI task was three questions from the WPPSI-R reflecting comprehension of the numerical concepts of one and two.…”

Section: Ef Assessmentmentioning

confidence: 87%

Executive Functioning in Preschool-Age Children Prenatally Exposed to Alcohol, Cocaine, and Marijuana

Noland¹,

Singer²,

Arendt³

et al. 2003

Alcoholism: Clinical & Experimental Research

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Background-Reports from clinical and experimental (animal) research converge on the suggestion that prenatal exposure to alcohol, cocaine, or marijuana undermines executive functioning (EF) and its neurological underpinnings. However, large, adequately controlled, prospective studies of alcohol and marijuana effects on EF have reported conflicting findings, and there have been no such studies of cocaine exposure.

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“…Furthermore, animals exposed to prenatal alcohol showed motor deficits similar to those in our ISO-3 subjects. 39 Our subjects underwent cognitive tests to determine the effect of isoflurane exposure on learning and memory (data currently being analyzed). Based on our findings of motor reflex deficits, we expect to see cognitive impairment in ISO-3 animals, while ISO-1 animals might be less impaired.…”

Section: Discussionmentioning

confidence: 99%

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

Coleman

Robertson

Dissen

et al. 2017

Survey of Anesthesiology

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Background-Experimental evidence correlates anesthetic exposure during early development with neuronal and glial injury and death as well as behavioral and cognitive impairments in young animals. Several, although not all, retrospective human studies of neurocognitive and behavioral disorders following childhood exposure to anesthesia suggest a similar association. Few studies have specifically investigated the effects of infant anesthesia exposure on subsequent

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Moderate Alcohol During Pregnancy: Learning and Behavior in Adolescent Rhesus Monkeys

Cited by 57 publications

References 61 publications

Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE

Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE

Executive Functioning in Preschool-Age Children Prenatally Exposed to Alcohol, Cocaine, and Marijuana

Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques

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