Moderate Alcohol Consumption Reduces Urinary 8-Hydroxydeoxyguanosine by Inducing of Uric Acid.

Abstract

Recent studies suggest that moderate alcohol consumption is associated with a low risk of cancer, coronary heart disease, and other diseases. Most of these diseases are considered to be related to the action of reactive oxygen species (ROS) at certain stages of disease progression. However, considerable evidence exists indicating that ethanol generates ROS in vivo. Thus, the reduced risk of disease as a result of alcohol consumption seems to contradict evidence suggesting the induction of ROS by ethanol. In the present study, we investigated whether oxidative stress was induced in moderate alcohol drinkers. We measured the total urinary biopyrrins and 8-hydroxydeoxyguanosine (8-OHdG) levels as a systemic oxidative stress marker and an oxidative DNA damage marker, respectively. Serum uric acid was also measured as an alcohol-induced antioxidant. We compared total urinary biopyrrins and 8-OHdG levels among groups with different alcohol habits. The results showed that total biopyrrins levels increased with the amount of alcohol consumed, but that the level of 8-OHdG significantly decreased with the amount of alcohol consumed. The decrease in 8-OHdG levels seemed to be associated with increasing levels of uric acid. Judging from the increasing level of total biopyrrins, alcohol may induce ROS. ROS may then cause cell damage in liver, as suggested by the positive correlation between the total biopyrrins levels and the serum GOT, GPT, and γ γ γ γ γ-GTP levels. However, since ROS may be more effectively counteracted by uric acid in organs other than the liver, DNA damage may be surpressed rather than induced. Accordingly, moderate alcohol consumption seems to have the overall effect of reducing DNA damage, as shown by the decrease in urinary 8-OHdG levels observed in our study.

Relationship between Urinary 15-F2t-Isoprostane and 8-Oxodeoxyguanosine Levels and Breast Cancer Risk

“…Increased urinary 15-F 2t -IsoP levels after alcohol administration were observed in a small study (40). In addition, 8-oxodG levels may be elevated by alcohol consumption (41) although others reported no effect of alcohol intake on urinary (42) or leukocyte DNA (43) 8-oxodG levels. In our study, lifetime alcohol consumption was not associated with either 15-F 2t -IsoP or 8-oxodG levels.…”

Effort?reward imbalance and physical health among Japanese workers in a recently downsized corporation

“…The reason for the negative findings remains unknown; however, some possibilities can be considered. First, with respect to biopyrrins, their urinary secretion was reported to increase in relation to age (Okamura 1990) and alcohol consumption (Yoshida et al 2001). The amount of biopyrrins was not associated with the ERI model, even when those factors and other oxidation-related factors, such as BMI, smoking, physical activity and history of (Morita et al 2001;Yamaguchi et al 1996).…”

Sunlight Exposure–Mediated DNA Damage in Young Adults

“…We carried out binary logistic regression analysis with creatinine-adjusted urinary 8-OHdG level (>8 mg/g creatinine) as the dependent variable and sunlight exposure time per day (hours per day), ratio of sunlight-exposed skin area to the whole body, sunlight intensity (mW/cm 2 ), L*-value (lightness) in the skin, and regular use of full-spectrum (i.e., UVA and UVB) sunscreen as independent variables (Table 1). Models were adjusted for age, sex, smoking, drinking, and BMI because correlations between urinary 8-OHdG levels and these factors have been reported (18,(21)(22)(23). We used the SPSS (version 18) software package (SPSS Japan …”