Sunlight Exposure–Mediated DNA Damage in Young Adults

Kato, Masashi; Iida, Machiko; Goto, Yuji; Kondo, Takaaki; Yajima, Ichiro

doi:10.1158/1055-9965.epi-11-0228

Cited by 32 publications

(21 citation statements)

References 29 publications

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“…(13) The 8-OHdG levels of our study cohort were not higher than those reported in healthy people by Kato et al (36) Also, the …”

Section: Discussioncontrasting

confidence: 40%

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Kotani

Yamada²

2014

smedj

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The Asia-Pacific region is facing an epidemic of type 2 diabetes mellitus (T2DM), paralleled by high rates of cardiovascular disease (CVD).(1,2) Hypertension (HT) remains a major risk factor for CVD in the region. On DNA oxidation, a hydroxyl group is added to the guanine molecule to form 8-hydroxyguanine, which on oxidative modification yields the product, 8-hydroxy-2'-deoxyguanosine (8-OHdG). (7,8) Hyperglycaemia promotes glucose oxidation and protein glycation, impairs DNA repair with resultant DNA cleavage, and generates reactive oxygen species, thereby leading to increased oxidative stress. (4,7,8) Similarly, HT is accompanied by the formation of advanced glycation end products, and thereby increased oxidative stress and DNA damage. (9,10) For these reasons, the measurement of 8-OHdG has been used by various researchers to evaluate the DNA oxidation associated with the pathophysiology of T2DM and HT. (4,(11)(12)(13)(14)(15)(16) A study by Nishikawa et al found that urinary 8-OHdG levels were increased in T2DM patients with poor glycaemic control, (4) while a study by Espinosa et al reported that urinary 8-OHdG levels were increased in patients with HT.However, Roselló-Lletí et al demonstrated that patients with HT and DM do not exhibit any differences with regard to 8-OHdG levels when compared to patients with HT but no DM.Espinosa et al also reported that 8-OHdG levels were reduced following antihypertensive treatment in patients with HT.(13) Studies suggest lowered urinary 8-OHdG levels upon intervention with antidiabetic agents in T2DM patients, Barengo and Tuomilehto reported that the presence of HT as a comorbidity in the hyperglycaemic state increased CVD

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“…(13) The 8-OHdG levels of our study cohort were not higher than those reported in healthy people by Kato et al (36) Also, the …”

Section: Discussioncontrasting

confidence: 40%

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Kotani

Yamada²

2014

smedj

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“…Statistical analyses using the Mann-Whitney U test and Spearman’s rank correlation test were performed following the method previously described [27]. The SPSS (version 18) software package (SPSS Japan Inc.) was used for these statistical analyses.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Barium and Arsenic Concentrations in Well Drinking Water and in Human Body Samples and a Novel Remediation System for These Elements in Well Drinking Water

et al. 2013

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Health risk for well drinking water is a worldwide problem. Our recent studies showed increased toxicity by exposure to barium alone (≤700 µg/L) and coexposure to barium (137 µg/L) and arsenic (225 µg/L). The present edition of WHO health-based guidelines for drinking water revised in 2011 has maintained the values of arsenic (10 µg/L) and barium (700 µg/L), but not elements such as manganese, iron and zinc. Nevertheless, there have been very few studies on barium in drinking water and human samples. This study showed significant correlations between levels of arsenic and barium, but not its homologous elements (magnesium, calcium and strontium), in urine, toenail and hair samples obtained from residents of Jessore, Bangladesh. Significant correlation between levels of arsenic and barium in well drinking water and levels in human urine, toenail and hair samples were also observed. Based on these results, a high-performance and low-cost adsorbent composed of a hydrotalcite-like compound for barium and arsenic was developed. The adsorbent reduced levels of barium and arsenic from well water in Bangladesh and Vietnam to <7 µg/L within 1 min. Thus, we have showed levels of arsenic and barium in humans and propose a novel remediation system.

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“…Nonetheless, some mutation patterns cannot be explained by UV-induced mutational signatures. These patterns may instead be explained by AID-induced DNA damage or oxidative DNA damage via the production of 8-hydroxydeoxyguanosine by UVB irradiation (56). A previous study showed that UVB irradiation promotes skin tumor formation in mice treated with DMBA alone, suggesting that UV light can act as a tumor promoter and synergize with DMBA (57).…”

Section: Tp53 Mutations In Human Cutaneous Scc In the Uv-protected Rementioning

confidence: 99%

Involvement of activation-induced cytidine deaminase in skin cancer development

Nonaka¹,

Toda²,

Hayashi³

et al. 2016

Journal of Clinical Investigation

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Sunlight Exposure–Mediated DNA Damage in Young Adults

Abstract: Background: Previous experimental studies showed that single ultraviolet B (UVB) light irradiation increased levels of 8-hydroxy-2 0 -deoxyguanosine (8-OHdG), a well-established biomarker of carcinogenesis

Cited by 32 publications

References 29 publications

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Comparison of Barium and Arsenic Concentrations in Well Drinking Water and in Human Body Samples and a Novel Remediation System for These Elements in Well Drinking Water

Involvement of activation-induced cytidine deaminase in skin cancer development

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