Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study

Abstract

Objectives To investigate whether moderate alcohol consumption has a favourable or adverse association or no association with brain structure and function. Design Observational cohort study with weekly alcohol intake and cognitive performance measured repeatedly over 30 years (1985-2015). Multimodal magnetic resonance imaging (MRI) was performed at study endpoint (2012-15). Setting Community dwelling adults enrolled in the Whitehall II cohort based in the UK (the Whitehall II imaging substudy). Participants 550 men and women with mean age 43.0 (SD 5.4) at study baseline, none were “alcohol dependent” according to the CAGE screening questionnaire, and all safe to undergo MRI of the brain at follow-up. Twenty three were excluded because of incomplete or poor quality imaging data or gross structural abnormality (such as a brain cyst) or incomplete alcohol use, sociodemographic, health, or cognitive data. Main outcome measures Structural brain measures included hippocampal atrophy, grey matter density, and white matter microstructure. Functional measures included cognitive decline over the study and cross sectional cognitive performance at the time of scanning. Results Higher alcohol consumption over the 30 year follow-up was associated with increased odds of hippocampal atrophy in a dose dependent fashion. While those consuming over 30 units a week were at the highest risk compared with abstainers (odds ratio 5.8, 95% confidence interval 1.8 to 18.6; P≤0.001), even those drinking moderately (14-21 units/week) had three times the odds of right sided hippocampal atrophy (3.4, 1.4 to 8.1; P=0.007). There was no protective effect of light drinking (1-<7 units/week) over abstinence. Higher alcohol use was also associated with differences in corpus callosum microstructure and faster decline in lexical fluency. No association was found with cross sectional cognitive performance or longitudinal changes in semantic fluency or word recall. Conclusions Alcohol consumption, even at moderate levels, is associated with adverse brain outcomes including hippocampal atrophy. These results support the recent reduction in alcohol guidance in the UK and question the current limits recommended in the US.

Alcohol Drinking Exacerbates Neural and Behavioral Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease

“…These results agree with recent evidence from a 30-year longitudinal cohort study in humans showing that long-term moderate alcohol drinking is associated with hippocampal atrophy (Topiwala et al, 2017) and suggest that 3xTg-AD mice may show vulnerability to alcoholinduced pathology in the HPC.…”

Relation between alcohol consumption in midlife and dementia in late life

“…Risk was also significantly increased among participants with at least one alcohol related hospital admission, and presence of alcohol dependence. These findings are consistent with previous research, also from the Whitehall II cohort, reporting >14 units/week alcohol consumption is associated with hippocampal atrophy and faster cognitive decline 9,10…”

Effects of drinking on late-life brain and cognition

“…We found a novel dose-dependent association between alcohol intake and hippocampal atrophy. Just 14–21 units (112–168 g) of alcohol weekly was associated with almost three times odds of hippocampal atrophy compared with abstinence 46. Additionally, alcohol consumption in non-dependent drinkers was associated with lower white matter integrity, particularly of the corpus callosum, and faster cognitive decline on lexical fluency, a complex executive task necessitating generation of words beginning with a specific letter within a time limit.…”