Relation between alcohol consumption in midlife and dementia in late life

Yaşar, Sevil

doi:10.1136/bmj.k3164

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Resveratrol derivatives have also been implied as potential therapeutic targets in AD ( 113 ). Due to the risk factors between alcohol consumption and other health conditions, red wine should be consumed in moderation because the beneficial effects have been linked to resveratrol, not ethanol (alcohol) ( 114 ). Averaging more than 12 grams of alcohol daily may increase dementia risk ( 115 ).…”

Section: Common Nutrients In Healthy and Plant-based Dietsmentioning

confidence: 99%

Diet and lifestyle impact the development and progression of Alzheimer’s dementia

Arora

Santiago²,

Bernstein

et al. 2023

Front. Nutr.

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Dementia is a growing public health concern, with an estimated prevalence of 57 million adults worldwide. Alzheimer’s disease (AD) accounts for 60–80% of the cases. Clinical trials testing potential drugs and neuroprotective agents have proven futile, and currently approved drugs only provide symptomatic benefits. Emerging epidemiological and clinical studies suggest that lifestyle changes, including diet and physical activity, offer an alternative therapeutic route for slowing and preventing cognitive decline and dementia. Age is the single most common risk factor for dementia, and it is associated with slowing cellular bioenergetics and metabolic processes. Therefore, a nutrient-rich diet is critical for optimal brain health. Furthermore, type 2 diabetes (T2D) is a risk factor for AD, and diets that reduce the risk of T2D may confer neuroprotection. Foods predominant in Mediterranean, MIND, and DASH diets, including fruits, leafy green vegetables, fish, nuts, and olive oil, may prevent or slow cognitive decline. The mechanisms by which these nutrients promote brain health, however, are not yet completely understood. Other dietary approaches and eating regimes, including ketogenic and intermittent fasting, are also emerging as beneficial for brain health. This review summarizes the pathophysiology, associated risk factors, and the potential neuroprotective pathways activated by several diets and eating regimes that have shown promising results in promoting brain health and preventing dementia.

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Section: Common Nutrients In Healthy and Plant-based Dietsmentioning

confidence: 99%

Diet and lifestyle impact the development and progression of Alzheimer’s dementia

Arora

Santiago²,

Bernstein

et al. 2023

Front. Nutr.

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“…Recent studies have tended to show that moderate alcohol consumption has a neuroprotective action, including beneficial effects in Parkinson's disease, Alzheimer's disease, and dementia. Even though the underlying mechanisms have not been fully characterized, researchers suggest that ethanol has an antiinflammatory effect and increases neuroplasticity [17][18][19][20]. Furthermore, low-to-moderate ethanol consumption has also been linked to lower pain levels in and the delayed onset of Meniere's disease [21,22].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Ethanol: A Review

Daré

Gicquel

2019

J Pharm Pharm Sci

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Purpose: To review knowledge on therapeutic uses of ethanol and the latter’s effectiveness and safety profiles in a range of indications. Methods: MEDLINE and PubMed databases were searched for relevant peer-reviewed papers published in English between 1888 and 2018 using the following search terms: ethanol, therapeutic, alcohol withdrawal syndrome, antiseptic, antidote, methanol, ethylene glycol, neurolysis, embolization, cyst, sclerosing agent, sclerotherapy, arteriovenous malformations, ablating agent. Studies providing information about association between alcohol and therapeutic indications, or mechanic explanation for the association were included for review. Results: According to the World Health Organization, approximately three millions deaths worldwide are attributable to alcohol consumption each year. However, the low-to-moderate consumption of ethanol has a number of beneficial effects (mainly on cardiovascular mortality and diabetes). Hence, ethanol has an unusual spectrum of effects that seems interesting for therapeutic purposes. Ethanol’s risk-benefit ratio appears to be positive in some therapeutic indications such as antidote to methanol or ethylene glycol poisoning, neurolysis, alcohol withdrawal syndrome, or antiseptic. Conclusion: With the development of interventional radio technologies, and thus extremely precise access to anatomical structures, alcohol has been given new indications - particularly as an embolization, sclerosing or ablation agent. Moreover, constant progress in our knowledge of ethanol’s pharmacodynamics might highlight other therapeutic indications for this compound in the future. Ethanol’s low cost and wide availability make it a valuable therapeutic agent, compared with other reference treatments. Furthermore, ethanol has a long track record of safety and effectiveness in the indications mentioned above.

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“…The public might be confused by The BMJ ’s editorial on the relation between alcohol consumption and Alzheimer’s disease, which was based on an observational study 1. The editorial’s salient message was that moderate alcohol consumption can ward off Alzheimer’s disease.…”

mentioning

confidence: 99%

“…Against this backdrop the public might be muddled by The BMJ ’s editorial, which noted that the matter is complicated and that a randomised trial is required to assess the evidence 1. Observational studies only suggest association and do not establish causation 7.…”

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confidence: 99%