Models of logistic regression analysis, support vector machine, and back-propagation neural network based on serum tumor markers in colorectal cancer diagnosis

B, Zhang; Liang, Xiaotao; Gao, Hengjun; Ye, L S; Wang, Y G

doi:10.4238/gmr.15028643

Cited by 25 publications

(24 citation statements)

References 18 publications

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“…There were statistical significances with OS (B) in the subgroups of gender, age group (>65), T3-T4 stage, N2 stage, tumor location, venous invasion and perineural invasion, protrude type, ulcerative typ, well/moderate differentiation, postoperative chemoradiotherapy. Full-size  DOI: 10.7717/peerj.8936/ fig-4 improve the high rate of CRC on diagnosis (Kunizaki et al, 2016;Zhang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

Kuang

Gong

Xie

et al. 2020

PeerJ

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Background and Purpose There had been no recognized serum tumor marker to predict the prognosis of colorectal cancer (CRC) patients with normal preoperative serum carcinoembryonic antigen (CEA) levels. The purpose of this study was to determine whether preoperative serum carbohydrate antigen 724 (CA724) was of predictive function for the prognosis of CRC patients with normal CEA levels. Methods The medical records of 295 CRC patients with normal CEA levels who underwent surgery at the Department of Colorectal Anal Surgery of the First Affiliated Hospital of Guangxi Medical University (Guangxi, China) between September 2012 and September 2014 were retrospectively reviewed. The Chi-square test was used to test the correlation between preoperative serum CA724 levels and clinical features. Kaplan–Meier curves were conducted to calculate the overall survival (OS) rate and disease-free survival (DFS) of patients. Cox regression analysis was applied to conduct univariate and multivariate analysis of the following four preoperative serum tumor makers namely CA724, carbohydrate antigen 199 (CA199), carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen 242 (CA242) and clinical features. Nomograms for prognostic parameter of OS and DFS were developed using R v3.2.5. Results In the Chi-square test, only pathological node stage (pN stage) (X2 = 14.514, P = 0.001) and differentiation (X2 = 10.712, P = 0.001) were associated with serum CA724 levels. In the Kaplan–Meier analysis, the results revealed that the OS and DFS in patients with high CA724 was poorer than those with normal. In the multivariate Cox regression analysis of OS and DFS, only pT stage, pN stage, metastasis and serum CA724 were independent prognostic risk factors for CRC patients with normal CEA levels. Conclusion Preoperative serum CA724 might serve as a potential prognostic factor for CRC patients with normal serum CEA levels.

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Section: Discussionmentioning

confidence: 99%

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

Kuang

Gong

Xie

et al. 2020

PeerJ

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“…To the best of our knowledge, there was no a specific serum tumor marker to diagnose CRC despite of the fact that many researchers and scientists had poured great efforts in it. The combined use or supplementary application of the above known serum biomarkers was considered to be potentially effective and practical way to improve the high rate of CRC on diagnosis (Kunizaki et al 2016;Zhang et al 2016). CEA was an important serum marker for evaluating prognosis of CRC patients (Lech et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #3 of "The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients (v0.2)"

2020

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There had been no recognized serum tumor marker to predict the prognosis of colorectal cancer (CRC) patients with normal preoperative serum carcinoembryonic antigen (CEA) levels. The purpose of this study was to determine whether preoperative serum carbohydrate antigen 724 (CA724) was of predictive function for the prognosis of CRC patients with normal CEA levels. Methods: The medical records of 295 CRC patients with normal CEA levels who underwent surgery at the Department of Colorectal Anal Surgery of the First Affiliated Hospital of Guangxi Medical University (Guangxi, China) between September 2012 and September 2014 were retrospectively reviewed. Chisquare test was used to test the correlation between preoperative serum CA724 levels and clinical features. Kaplan-Meier curves were conducted to calculate the overall survival (OS) rate and disease-free survival (DFS) of patients. Cox regression analysis was applied to conduct univariate and multivariate analysis of the following four preoperative serum tumor makers namely CA724, carbohydrate antigen 199 (CA199), carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen 242 (CA242) and clinical features. Nomograms for prognostic parameter of OS and DFS were developed using R v3.2.5. Results: In the Chi-square test, only pathological node stage (pN stage) (X 2 =14.514, P=0.001) and differentiation (X 2 =10.712, P=0.001) were associated with serum CA724 levels. In the Kaplan-Meier analysis, the results revealed that the OS and DFS in patients with high CA724 was poorer than those with normal. In the multivariate Cox regression analysis of OS and DFS, only pT stage, pN stage, metastasis and serum CA724 were independent prognostic risk factors for CRC patients with normal CEA levels. Conclusion: Preoperative serum CA724 might serve as a potential prognostic factor for CRC patients with normal serum CEA levels.

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“…This result implied that the combined detection of multiple tumor markers is valuable in differentiating colon cancer from non-cancerous tissue. This could effectively improve the early diagnosis rate of colon cancer[17].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of sentinel polyps and their correlation with proximal colon cancer: A retrospective observational study

Wang

Kong

et al. 2019

WJCC

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BACKGROUNDColorectal cancer is a common malignant tumor of the digestive tract. The relationship between sentinel polyps (rectal polyps with proximal colon cancer) and proximal colon cancer has received extensive attention in recent years. However, there is still no clear conclusion regarding the relationship.AIMTo investigate the clinical characteristics of sentinel polyps and their correlation with proximal colon cancer.METHODSA retrospective analysis of 2587 patients with rectal polyps from January 2006 to December 2017 was performed. According to whether or not proximal colon cancer was diagnosed, the patients were divided into either a sentinel polyp group (192 patients) or a pure rectal polyp group (2395 patients). The endoscopic features, clinicopathological features, therapeutic effects, and short-term prognosis were analyzed and compared between the two groups.RESULTSThe mean age of patients in the sentinel polyp group was generally higher than that of the pure rectal polyp group, and the positivity rates of anemia, stool occult blood, and tumor markers of the sentinel polyp group were also significantly higher than those in the rectal polyp group (χ2 = 90.56, P < 0.01; χ2 = 70.30, P < 0.01; χ2 = 92.80, P < 0.01). The majority of the patients in the sentinel polyp group had multiple polyps, large polyps, adenomatous polyps, or sessile polyps (χ2 = 195.96, P < 0.01; χ2 = 460.46, P < 0.01; χ2 = 94.69, P < 0.01; χ2 = 48.01, P < 0.01). Most of the proximal colon cancers were Duke’s A and B stages in the sentinel polyp group. In the pure rectal polyp group, 2203 patients underwent endoscopic treatment, and all of the patients were cured and discharged. In the sentinel polyp group, 65 patients underwent radical operation, and 61 patients received endoscopic submucosal dissection or endoscopic mucosal resection. Additionally, 21 patients were lost to follow-up after 6-12 mo, and the loss rate was 10.94%. A total of 63.16% of patients experienced remission without tumor recurrence or metastasis, 33.33% of patients experienced tumors regression or improved symptoms, and the other 3.51% of the patients died.CONCLUSIONIf there are multiple, sessile, and adenomatous rectal polyps with a maximum diameter > 1 cm, the possibility of the carcinogenesis of the polyps or of the proximal colon should be monitored closely. These patients should be followed in the short-term and should undergo a whole-colon examination.

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Models of logistic regression analysis, support vector machine, and back-propagation neural network based on serum tumor markers in colorectal cancer diagnosis

Cited by 25 publications

References 18 publications

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

Peer Review #3 of "The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients (v0.2)"

Clinical characteristics of sentinel polyps and their correlation with proximal colon cancer: A retrospective observational study

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