Models for Investigating Placental Biology

Pence, Laramie; Telugu, Bhanu P.

doi:10.1002/9781118881286.ch3

Cited by 2 publications

(2 citation statements)

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“…In contrast, the interface in rats is comprised of three layers and is therefore hemotrichorial (Table 2). This difference between rats and humans might affect fetal-maternal exchange processes in the placental barrier 85 .…”

Section: Comparison With Human Placentamentioning

confidence: 99%

“…Multinucleated trophoblastic giant cells are present in the deep basal plate at the myometrial border. The basal plate is roughly analogous to the basal zone in rats, based on to its anatomical location 85 , but the morphology is not necessarily similar. Therefore, caution is required in extrapolation of toxicological effects on the basal zone from the rat placenta to the human placenta.…”

Section: Comparison With Human Placentamentioning

confidence: 99%

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Morphology and physiology of rat placenta for toxicological evaluation

2019

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The placenta plays a pivotal role in fetal growth, and placental dysfunction and injury are associated with embryo/fetal toxicity. Histological examination of the rat placenta for safety evaluation provides valuable clues to the mechanisms of this toxicity. However, the placenta has specific and complex biological features unlike those of other organs, and placental structure dramatically changes depending on the time during the gestation period. Thus, time-dependent histopathological examination of the rat placenta should be performed based on the understanding of normal developmental changes in morphology and function. The placentas of rats and humans are both anatomically classified as discoid and hemochorial types. However, there are differences between rats and humans in terms of placental histological structure, the fetal-maternal interface, and the function of the yolk sac. Therefore, extrapolation of placental toxicity from rats to humans should be done cautiously in the evaluation of risk factors. This review describes the development, morphology, physiology, and toxicological features of the rat placenta and the differences between the rat and human placenta to enable accurate evaluation of reproductive and developmental toxicity in studies.

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Section: Comparison With Human Placentamentioning

confidence: 99%

Section: Comparison With Human Placentamentioning

confidence: 99%