Modelos experimentales de isquemia cerebral

Prieto-Arribas, R.; Moreno-Gutiérrez, Adrián; Simal‐Hernández, Patricia; Pascual, José M.; Matías-Guiu, J; Roda, José; Barcia-Albacar, J A

doi:10.33588/rn.4708.2008233

Cited by 9 publications

(5 citation statements)

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“…Therefore, future studies on clarifying the underlying mechanisms behind the effect of reperfusion/revascularization therapy on ACI should also take into account the thrombolysis treatment combined with endovascular therapy. Finally, there are many different experimental models of cerebral ischaemia . Because of the simplicity of the model, one model is insufficient to mimic all the phenotypes of clinical patients.…”

Section: Discussionmentioning

confidence: 99%

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Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke

Liu

et al. 2019

J Cellular Molecular Medi

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Recombinant tissue plasminogen activator (rt‐ PA ) is the first‐line drug for revascularization in acute cerebral infarction ( ACI ) treatment. In this study, an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke was used and the rats were killed on the first, third and seventh day after model establishment. Increases in infarct volume were significantly less in the thrombolytic group than in the conventional group at every time‐point. The microvascular density ( MVD ) in the thrombolytic group was significantly higher than that in the conventional group at every time‐point, especially on the seventh day. Increases in the expressions of neuronal nitric‐oxide synthase ( NOS ) and caspase‐3 in the ischaemic region and in the nitric oxide contents, malondialdehyde contents, and inducible NOS activities in the cortex of infarct side were significantly less in the thrombolytic group than in the conventional group. Furthermore, decreases in the superoxide dismutase activities in the thrombolytic group were significantly less than those in the conventional group. In conclusion, thrombolytic rt‐ PA therapy within a broadened therapeutic window (6 hours) could significantly decrease the infarct volume after ACI , possibly by increasing MVD in the ischaemic region, decreasing apoptotic molecule expression, and alleviating the oxidative stress response.

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Section: Discussionmentioning

confidence: 99%

“…Finally, there are many different experimental models of cerebral ischaemia. 37 Because of the simplicity of the model, one model is insufficient to mimic all the phenotypes of clinical patients. Therefore, it would be interesting to perform the same analyses of this study using different experimental models of cerebral ischaemia.…”

mentioning

confidence: 99%

Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke

Liu

et al. 2019

J Cellular Molecular Medi

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“…[41][42] Various techniques have been developed to find the right animal model to assess deficiencies in memory and learning, considering the models of focal or incomplete cerebral ischemia the most efficient, since one of the areas affected in hypoxia is the hippocampus (Table 1). [43][44][45]…”

Section: Model Of Permanent Occlusion Of Common Carotid Arteries (Opacc's) In Ratsmentioning

confidence: 99%

“…NO's participation in learning and memory is from a retrograde messenger during long-term empowerment (LTP) an important process for memory formation. [45][46][47][48][49] The base stock of these animals was initially established at Massachusetts General Hospital (Boston, MA). 50 The nNOS gene mutation is generated by homologous recombination.…”

Section: Gene Suppression Technologiesmentioning

confidence: 99%

Potential Neuroprotective Activity of Essential Oils in Memory and Learning Impairment

Silva-Correa¹,

Campos-Reyna²,

Torre³

et al. 2021

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Learning and memory are linked, but they are different. Learning is a process by which knowledge about the environment is acquired and memory is the process by which knowledge is encoded, consolidated, stored and then retrieved. [10][11] Coding involves processes by which newly learned information is received when it is for the first time.Consolidation is a process that modifies newly stored and still labile information to make it more stable for long-term storage. Consolidation involves the expression of genes and the synthesis of new proteins, resulting in structural changes that store memory in a stable way over time. Storage refers to mechanisms and places that retain information over time. Recovery are processes that enable the retrieval and use of stored information. [12][13][14] Various types of memory have been proposed over the years,

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“…One of the numerous models of cerebral ischemia used for evaluation of drug effi ciencies is ligation of the common carotid arteries leading to the formation of cerebral circulation reduction similar to ischemic stroke [6,9]. According to some reports, simultaneous bilateral ligation of the common carotid arteries in rats leads to death of 70-100% experimental animals mainly during the fi rst 2-3 days of observation, this impeding studies of the time course of recovery and evaluation of therapy effi ciency [2,4,5,10,11].…”

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confidence: 99%

A Model of Cerebral Circulation Disorders Created by Staged Ligation of the Common Carotid Arteries

Fateev¹,

Быков²,

Чепур³

et al. 2012

Bull Exp Biol Med

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A model of brain ischemia induced by staged ligation of the left and right common carotid arteries has been developed in experiments on rats. The use to this model led to reduction of animal mortality. On days 2-5 after the second ligature, the animals lost weight, the level of their CNS vulnerability increased, the volume of perceived information reduced, adaptation to environmental conditions and reproduction of conditioned reflexes were disordered. Focal and diffuse destructive changes in the nerve and glia cells were found in the cerebral cortex, hippocampus, and thalamic nuclei. The severity of disorders in the blood supply to the brain depended on the interval between ligation of the carotid arteries. This recommends this model for evaluation of the efficiency of drugs of various pharmacological groups.

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Modelos experimentales de isquemia cerebral

Cited by 9 publications

References 0 publications

Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke

Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke

Potential Neuroprotective Activity of Essential Oils in Memory and Learning Impairment

A Model of Cerebral Circulation Disorders Created by Staged Ligation of the Common Carotid Arteries

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