Modelling of a planar magnetic micropusher for biological cell manipulations

Abstract

To cite this version:Michaël Dauge, Michaël Gauthier, Emmanuel Piat. Modelling of a planar magnetic micropusher for biological cell manipulations.. Sensors and Actuators A: Physical , Elsevier, 2007, 138, pp.239-247. <hal-00162038> The improving of the efficiency and the automation of biological cell technologies is currently of great importance. One way is to build biological micro-factories which are able to perform complete biotechnological processes automatically. This technology requires the development of new automatic cell transport system to feed work stations in microfactories. An original magnetic cell micropusher is described in this paper. The ferromagnetic pusher which is submerged in the biological medium follows the movement of a permanent magnet located in the air. This paper focuses on the modelling of the dynamic behaviour of the micropusher according to the magnet trajectory. The generic model proposed is able to determine pusher trajectory according to the micropusher magnetic properties and the permanent magnet shape and properties. This simulation tool will permit to optimize and to study cell trajectory control in further works.Area -Micromechanics.

Herramienta para la simulación del movimiento de un micro robot para aplicaciones médicas a partir de un arreglo de bobinas basadas en Maxwell – Helmholtz. (Herramienta de simulación para navegación de microrobots).

“…El uso de electroimanes da como ventaja el control directo de los campos magnéticos y gradientes generados, y por ende, un control más preciso del micro robot en el medio. Pero en cambio la desventaja se presenta en la cantidad de energía necesaria para alimentar dichos sistemas, requiriendo equipos dedicados, manejo de altas corrientes y derivado a esto último, alto consumo de potencia y generación de calor, lo cual podría afectar el rendimiento esperado (Dauge et al, 2007;Hagiwara et al, 2011).…”

Autonomous dynamic obstacle avoidance for bacteria-powered microrobots (BPMs) with modified vector field histogram

“…For biomedical engineering, core tasks such as localized/targeted drug delivery, micro invasive surgery, cell manipulation, biosensing, cell sorting, and cell fusion can be performed [ 1 – 6 ]. In the field of industrial engineering, microrobots have shown their capabilities to complete microscale tasks such as micro-assembly, transport, precision micro-machining, and micro-manipulation [ 7 – 9 ]. In order to develop swimming microrobots for these applications, there have been various challenges.…”

Powerful actuation of magnetized microtools by focused magnetic field for particle sorting in a chip

“…Cells can be manipulated indirectly using optical tweezers by noncontact actuation of microtools; as a result, cells would be at reduced risk of damage during manipulation; however, the generated force in such a case is on the order of several pico-newtons, which is not suitable for manipulating cells on the order of 100 μm. In contrast, the risk of cell contamination by a cell manipulation operation such as magnetic sorting is limited; also, magnetic sorters are inexpensive (Abbott et al 2007;Mensing et al 2004;Ryu et al 2004; Barbic et al 2001;Jackson et al 2001;Maruyama et al 1422;Yamanishi et al 2007b, c;Liu and Yi 1999;Rostaing et al 2006;Dauge et al 2007), which is not the case with the cell sorters conventionally employed in flow cytometry systems. Therefore, magnetic cell sorters have been employed in many studies.…”