Modelling breakage and reagglomeration during fine dry grinding in ball milling devices

Fadda, Sarah; Cincotti, Alberto; Concas, Alessandro; Pisu, Maria Giuseppina; Cao, Giacomo

doi:10.1016/j.powtec.2009.04.009

Cited by 65 publications

(38 citation statements)

References 23 publications

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“…D A refers to average particle size. As observed in Tables 3, for the grinding of There are four basic principles involved in size reduction, namely, by impact, attrition, compression, and disintegration by shearing [31]. There are three work models shown in Fig.…”

Section: Grinding Efficiency Experimentsmentioning

confidence: 99%

The utilization of sewage sludge by blending with coal water slurry

Xie

et al. 2015

Fuel

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Section: Grinding Efficiency Experimentsmentioning

confidence: 99%

The utilization of sewage sludge by blending with coal water slurry

Xie

et al. 2015

Fuel

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“…It showed that the size reduction of the fruit powder particles was not in a time-dependent manner but in a dynamic manner. This growth in the median diameter could also be the result of the micronization that makes the powder expose more water-binding sites to the surrounding water, and could also be due to the expression of surface forces, namely van der Waals, magnetic, and electrostatic forces (Fadda, Cincotti, Concas, Pisu, and Cao, 2009), leading to the agglomerate phenomenon of the powder. Table 1 also presents the spans of the different powders.…”

Section: Particle Sizementioning

confidence: 99%

“…And the temporal transition from a regime dominated by breakage to the one dominated by aggregative phenomenon is addressed by curves of micro-powders A and B which move inversion. Fadda et al (2009) discussed that phenomena of breakage and aggregation during grinding usually were simultaneously considered. And the trend of cumulative distribution curves paralleled that of the median diameter.…”

Section: Particle Sizementioning

confidence: 99%

Effects of micronization on properties of Chaenomeles sinensis (Thouin) Koehne fruit powder

Zhang

2009

Innovative Food Science & Emerging Technologies

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“…In addition, grinding of hydrophobic drugs usually causes aggregation of drug particles, therefore size reduction by dry milling is limited to around 3 µm due to aggregation between particles at sub-micron diameters [8]. These aggregates have a reduced effective surface area available for dissolution.…”

Section: Introductionmentioning

confidence: 99%

An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

et al. 2016

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An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine, Powder Technology (2016Technology ( ), doi: 10.1016Technology ( /j.powtec.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T AbstractOne of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forces during th e grinding process can lead to changes in the physicochemical characteristics as well as an increase in the surface free energy of the ground particles, which causes an alteration in the electrostatic properties of these particles. The solid state characteristics of glucosamine hydrochloride (GLU) and carbamazepine (CBZ) and their co-ground mixtures were studied using DSC, XRPD and SEM.These revealed that polymorphic transformations occurred due to the grinding process. The influence of grinding time on the triboelectrification properties of the formulations was also studied.Both pure CBZ and GLU powders were predominantly electro-positively charged and their charging properties increased with increasing grinding time. CBZ:GLU physical mixtures exhibited complicated bipolar charging behaviour, however, when subjected to grinding, these mixtures demonstrated mainly electronegative charge properties. The influence of both grinding time and CBZ content within CBZ:GLU mixtures were examined. The value of net-electronegative-charge density of CBZ:GLU mixtures was shown to increase with grinding time and /or when increasing the percentage proportion of CBZ up to 30 % w:w. This study helps to provide information about the handling of these formulation and gives a formulator tools to ascertain appropriate ratios for handling and possible simultaneous dissolution improvements.

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Modelling breakage and reagglomeration during fine dry grinding in ball milling devices

Cited by 65 publications

References 23 publications

The utilization of sewage sludge by blending with coal water slurry

The utilization of sewage sludge by blending with coal water slurry

Effects of micronization on properties of Chaenomeles sinensis (Thouin) Koehne fruit powder

An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

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