Modeling the synchronization of yeast respiratory oscillations

Henson, Michael A.

doi:10.1016/j.jtbi.2004.07.009

Cited by 25 publications

(14 citation statements)

References 36 publications

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“…Our primary motivation for this model is recent theoretical and experimental work on Yeast Autonomous Oscillations (YAO) ([47], [55], [9], [23], [31]), the periodic oscillations of physiologically relevant variables that have been reported and studied for over 40 years [9, 16, 28, 32, 37, 39, 40, 41, 44, 46, 49, 57, 60, 61] (and many others). Different types of YAO have been called metabolic [55], glycolytic [2] or respiratory [23] oscillations.…”

Section: Introductionmentioning

confidence: 99%

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Clustering in cell cycle dynamics with general response/signaling feedback

Young

Fernandez

Buckalew

et al. 2012

Journal of Theoretical Biology

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Motivated by experimental and theoretical work on autonomous oscillations in yeast, we analyze ordinary differential equations models of large populations of cells with cell-cycle dependent feedback. We assume a particular type of feedback that we call Responsive/Signaling (RS), but do not specify a functional form of the feedback. We study the dynamics and emergent behaviour of solutions, particularly temporal clustering and stability of clustered solutions. We establish the existence of certain periodic clustered solutions as well as “uniform” solutions and add to the evidence that cell-cycle dependent feedback robustly leads to cell-cycle clustering. We highlight the fundamental differences in dynamics between systems with negative and positive feedback. For positive feedback systems the most important mechanism seems to be the stability of individual isolated clusters. On the other hand we find that in negative feedback systems, clusters must interact with each other to reinforce coherence. We conclude from various details of the mathematical analysis that negative feedback is most consistent with observations in yeast experiments.

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Section: Introductionmentioning

confidence: 99%

“…Different types of YAO have been called metabolic [55], glycolytic [2] or respiratory [23] oscillations. The control of oscillation and the regulation of yeast metabolism has been an important theme in the chemical engineering literature devoted to the efficient management of bioprocesses [7, 21, 26, 53, 62].…”

Section: Introductionmentioning

confidence: 99%

Clustering in cell cycle dynamics with general response/signaling feedback

Young

Fernandez

Buckalew

et al. 2012

Journal of Theoretical Biology

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“…[8][9]. Proving the stability of synchronized oscillations of this simplified model (assuming that a single cell has a stable oscillation), by verifying condition (C1) of 3.1, is even easier than in the case of the full model, and no restriction on the parameters or nonlinearities is needed in this case.…”

Section: Substituting (521) Into (520) We Havėmentioning

confidence: 99%

“…A variety of modeling studies of biochemical systems of oscillators coupled through an environment, described by equations of the form (1.1),(1.2), can be found in [1,3,4,5,8,9,16,17,22,23,26,27,28]. The framework presented above thus unifies many models of particular systems, and allows us to obtain some basic analytical results which apply to all of them.…”

Section: Introductionmentioning

confidence: 99%

Synchronization of oscillators coupled through an environment

Katriel

2008

Physica D: Nonlinear Phenomena

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We study synchronization of oscillators that are indirectly coupled through their interaction with an environment. We give criteria for the stability or instability of a synchronized oscillation. Using these criteria we investigate synchronization of systems of oscillators which are weakly coupled, in the sense that the influence of the oscillators on the environment is weak. We prove that arbitrarily weak coupling will synchronize the oscillators, provided that this coupling is of the 'right' sign. We illustrate our general results by applications to a model of coupled GnRH neuron oscillators proposed by Khadra and Li [14], and to indirectly weakly-coupled λ − ω oscillators.

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“…6,7) H 2 S is produced from sulfite by sulfite reductase, 8) and pulse injection of cysteine or methionine at a concentration of 100 mM perturbed respiratory oscillation with changes in H 2 S production rhythm. 9) The feedback inhibition of sulfate uptake at high concentrations of cysteine is considered as a major source of oscillations 10,11) and SUL2, a high affinity sulfate permease, is cyclically expressed during respiratory oscillation. 12) When the cellular redox state is changed, H 2 S production and subsequent respiratory oscillation are perturbed.…”

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confidence: 99%

GLR1Plays an Essential Role in the Homeodynamics of Glutathione and the Regulation of H₂S Production during Respiratory Oscillation ofSaccharomyces cerevisiae

Sohn

Kum

Kwon

et al. 2005

Bioscience, Biotechnology, and Biochemistry

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The role of glutathione (GSH) and its homeodynamics during respiratory oscillation of Saccharomyces cerevisiae were investigated. Pulse injection of thiol redox modifying agents, such as diethylmaleate, N-ethylmaleimide, DL-butione-[S,R]-sulfoxamine, or 5-nitro-2-furaldehyde into the culture perturbed oscillation, although the degree of perturbation varied. Analysis of the expression profiles of GSH1 and GLR1, the activities of glutathione reductase, oscillations in cysteine and GSH concentrations, and the chemostat culture of the GLR1 disruptant indicated that GLR1 plays an essential role in the homeodynamics of GSH and the regulation of H(2)S production.

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Modeling the synchronization of yeast respiratory oscillations

Cited by 25 publications

References 36 publications

Clustering in cell cycle dynamics with general response/signaling feedback

Clustering in cell cycle dynamics with general response/signaling feedback

Synchronization of oscillators coupled through an environment

GLR1Plays an Essential Role in the Homeodynamics of Glutathione and the Regulation of H₂S Production during Respiratory Oscillation ofSaccharomyces cerevisiae

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Modeling the synchronization of yeast respiratory oscillations

Cited by 25 publications

References 36 publications

Clustering in cell cycle dynamics with general response/signaling feedback

Clustering in cell cycle dynamics with general response/signaling feedback

Synchronization of oscillators coupled through an environment

GLR1Plays an Essential Role in the Homeodynamics of Glutathione and the Regulation of H2S Production during Respiratory Oscillation ofSaccharomyces cerevisiae

Contact Info

Product

Resources

About

GLR1Plays an Essential Role in the Homeodynamics of Glutathione and the Regulation of H₂S Production during Respiratory Oscillation ofSaccharomyces cerevisiae