Modeling the Resonance Shifts Due to Coupling Between HTS Coils in NMR Probes

Thomas, J. N.; Ramaswamy, V.; Johnston, T L; Belc, D C; Freytag, Nicolas; Hornak, L.A.; Edison, Arthur S.; Brey, Wallace S.

doi:10.1088/1742-6596/1559/1/012022

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…Since each HTS coil's resonance frequency was appreciably shifted by the presence of the other resonators, the relevant probe resonances were the coupled resonances of all local resonators, not just the Helmholtz-like HTS pairs. A magnetic coupling model based on microwave filter theory was used to predict the individual coil resonance required to obtain the desired set of coupled modes and thereby, accurately tune the probe [12]. The 13 C coils were placed closest to the sample to maximize sensitivity by optimizing filling factor.…”

Section: Resultsmentioning

confidence: 99%

“…A 1.5 mm 13 C-optimized all-HTS probe [2] of similar design (but also including a 15 N channel) previously developed in our lab has shown to be a powerful tool for metabolomics applications [7][8][9][10][11]. In development of the new probe, advances in coil design and probe construction technique led to significantly higher resonator Qfactors [12,13]. However, the leap in resonator Q-factor has led to the encounter of new obstacles to overcome in their implementation.…”

Section: Introductionmentioning

confidence: 99%

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Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in ¹³C NMR Spectroscopy

Thomas

Johnston

Litvak

et al. 2022

J. Phys.: Conf. Ser.

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Nuclear magnetic resonance spectroscopy (NMR) probes using thin-film high temperature superconducting (HTS) resonators provide exceptional mass sensitivity in small-sample NMR experiments for natural products chemistry and metabolomics. We report improvements in sensitivity to our 1.5 mm 13C-optimized NMR probe based on HTS resonators. The probe has a sample volume of 35 microliters and operates in a 14.1 T magnet. The probe also features HTS resonators for 1H transmission and detection and the 2H lock. The probe utilizes a 13C resonator design that provides greater efficiency than our previous design. The quality factor of the new resonator in the 14.1 T background field was measured to be 4,300, which is over 3x the value of the previous design. To effectively implement the improved quality factor, we demonstrate the effect of adding a shorted transmission line stub to increase the bandwidth and reduce the rise/fall time of 13C irradiation pulses. Initial NMR measurements verify 13C NMR sensitivity is significantly improved while preserving detection bandwidth. The probe will be used for applications in metabolomics.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in ¹³C NMR Spectroscopy

Thomas

Johnston

Litvak

et al. 2022

J. Phys.: Conf. Ser.

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Versatile, Rapid, and Plasma‐Assisted Synthesis of Cuprous Halide Composites at Room Temperature and Pressure

Hartl

Ostrikov

MacLeod

2021

Adv Materials Technologies

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the hole concentration in CuI 1−x Br x can be controlled by modifying the stoichiometric ratio of the halides, demonstrating that these binary halides are promising candidates for tailored electronic properties in next-generation devices. [8] In addition to the compositional variation, disorderrelated effects contribute to the changes in the electronic and optical structure in these solid solutions. [9] With these electronic applications in mind, the synthesis of CuX films has become a hot topic in recent years, with a focus on chemical vapor deposition [10][11][12] and vacuum deposition techniques such as molecular beam epitaxy, [13,14] reactive sputtering, [15] and thermal evaporation. [8,16,17] At the same time, the cuprous halides are promising candidates for other applications, such as the use of CuBr in sensing, [18][19][20] or the use of CuCl as cathode in Mg primary batteries. [21] The growth of CuX on copper is also of interest for batteries, as CuCl/ Cu anodes are being investigated for use in lithium ion batteries (LIBs), [21][22][23] and LIBs comprising an anode made from Cu foam covered with a CuBr-and Br-doped graphene-like film exhibit dendrite-free operation and an increased cycling stability. [24] This ever-expanding suite of applications means that it is of considerable interest to identify new approaches to CuX synthesis. One outstanding challenge is integrating CuX into composite films, where only a limited amount of work has been done. For example, a polyvinyl alcohol (PVA)/CuI composite material, in which the inorganic crystals were synthesized directly within the polymer matrix through the reduction of CuCl 2 by NaI in aqueous PVA solution, has shown promise for photovoltaic applications. [25] Similarly, a polypyrrole/CuI composite film synthesized through a one-pot approach, demonstrated electrochemical sensing properties. [26] Composite films comprising inorganic nanoparticles within a polymer matrix provide advantages for certain applications, where their contrasting and/or complementary properties can create synergistic benefits. [27] Here, we demonstrate a versatile, single-step approach to synthesizing an array of CuX composite films. The process involves deposition of a halogen-containing liquid organic precursor onto a metal substrate, and subsequent application of a dielectric barrier discharge (DBD) plasma. DBD plasma creates a reactive environment, in which electrons, ions, ultraviolet radiation, and free radicals can contribute to reactions in suitable precursor molecules. [28] We have previously shown that exposure to DBD plasma causes cleaving of the CCl bonds Cuprous halides (CuX) are transparent semiconductors with a range of appealing characteristics, and with targeted applications in electronics, energy storage, and sensing. Here, it is demonstrated that CuX films can be formed at room temperature and atmospheric pressure using a rapid, plasma-based approach. Crystalline CuX products are formed using dielectric barrier discharge plasma to react liquid small-molecule precu...

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Use of sensitivity-enhanced nuclear magnetic resonance spectroscopy equipped with a 1.7-mm cryogenically cooled micro-coil probe in identifying human sperm intracellular metabolites

Cheredath,

Uppangala,

Jijo

et al. 2023

Reprod. Fertil. Dev.

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Context The clinical value of human sperm metabolites has not been established due to the technical complexity in detecting these metabolites when sperm numbers are low. Aims To detect endogenous intracellular metabolites in fresh and post-thaw human spermatozoa using 800 MHz nuclear magnetic resonance (NMR) spectroscopy equipped with a 1.7-mm cryo-probe. Methods Processed spermatozoa from 25 normozoospermic ejaculates were subjected to extraction of intracellular metabolites and then profiled by sensitivity-enhanced NMR spectroscopy equipped with a 1.7-mm cryogenically cooled micro-coil probe. In parallel, some of the processed sperm fractions were subjected to freeze-thawing and were then analysed for intracellular metabolites. Key results Twenty-three metabolites were profiled from only 1.25 million sperm cells. Comparison of the metabolomic signature of pre-freeze and post-thaw sperm cells did not show significant changes in the levels of metabolites. Conclusions Sensitivity-enhanced NMR spectroscopy equipped with a 1.7-mm cryogenically cooled micro-coil probe is a potential tool for identifying intracellular metabolites when sperm number is low. Implications Use of sensitivity-enhanced NMR spectroscopy opens up the opportunity to test for endogenous metabolites in samples with a limited number of spermatozoa, to understand the patho-physiology of infertility.

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Modeling the Resonance Shifts Due to Coupling Between HTS Coils in NMR Probes

Cited by 8 publications

References 13 publications

Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in ¹³C NMR Spectroscopy

Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in ¹³C NMR Spectroscopy

Versatile, Rapid, and Plasma‐Assisted Synthesis of Cuprous Halide Composites at Room Temperature and Pressure

Use of sensitivity-enhanced nuclear magnetic resonance spectroscopy equipped with a 1.7-mm cryogenically cooled micro-coil probe in identifying human sperm intracellular metabolites

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Modeling the Resonance Shifts Due to Coupling Between HTS Coils in NMR Probes

Cited by 8 publications

References 13 publications

Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in 13C NMR Spectroscopy

Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in 13C NMR Spectroscopy

Versatile, Rapid, and Plasma‐Assisted Synthesis of Cuprous Halide Composites at Room Temperature and Pressure

Use of sensitivity-enhanced nuclear magnetic resonance spectroscopy equipped with a 1.7-mm cryogenically cooled micro-coil probe in identifying human sperm intracellular metabolites

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Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in ¹³C NMR Spectroscopy

Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in ¹³C NMR Spectroscopy