Modeling the release of curcumin from microparticles of poly(hydroxybutyrate) [PHB]

Aguilar-Rabiela, A.E.; Hernández-Cooper, Ernesto M.; Vergara-Porras, Berenice

doi:10.1016/j.ijbiomac.2019.11.242

Cited by 16 publications

(38 citation statements)

References 26 publications

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“…The CIN encapsulation efficiency of PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20 microspheres was evaluated by the indirect analytical method described in the literature [ 39 ]. The amount of unentrapped CIN was used to calculate the total entrapped CIN in PHBV/MBGN microspheres.…”

Section: Methodsmentioning

confidence: 99%

Fabrication and Characterization of Cinnamaldehyde-Loaded Mesoporous Bioactive Glass Nanoparticles/PHBV-Based Microspheres for Preventing Bacterial Infection and Promoting Bone Tissue Regeneration

et al. 2021

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Polyhydroxybutyrate-co-hydroxyvalerate (PHBV) is considered a suitable polymer for drug delivery systems and bone tissue engineering due to its biocompatibility and biodegradability. However, the lack of bioactivity and antibacterial activity hinders its biomedical applications. In this study, mesoporous bioactive glass nanoparticles (MBGN) were incorporated into PHBV to enhance its bioactivity, while cinnamaldehyde (CIN) was loaded in MBGN to introduce antimicrobial activity. The blank (PHBV/MBGN) and the CIN-loaded microspheres (PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20) were fabricated by emulsion solvent extraction/evaporation method. The average particle size and zeta potential of all samples were investigated, as well as the morphology of all samples evaluated by scanning electron microscopy. PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20 significantly exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli in the first 3 h, while CIN releasing behavior was observed up to 7 d. Human osteosarcoma cell (MG-63) proliferation and attachment were noticed after 24 h cell culture, demonstrating no adverse effects due to the presence of microspheres. Additionally, the rapid formation of hydroxyapatite on the composite microspheres after immersion in simulated body fluid (SBF) during 7 d revealed the bioactivity of the composite microspheres. Our findings indicate that this system represents an alternative model for an antibacterial biomaterial for potential applications in bone tissue engineering.

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Section: Methodsmentioning

confidence: 99%

Fabrication and Characterization of Cinnamaldehyde-Loaded Mesoporous Bioactive Glass Nanoparticles/PHBV-Based Microspheres for Preventing Bacterial Infection and Promoting Bone Tissue Regeneration

et al. 2021

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“…Aguilar‐Rabiela, Hernández‐Cooper, Otero, and Vergara‐Porras (2020) proposed a physical model considering analogous heat and mass transfer. The mass balance model was solved based on the diffusion equation in this work.…”

Section: Mechanistic Realistic Release Modelsmentioning

confidence: 99%

Modeling the release of food bioactive ingredients from carriers/nanocarriers by the empirical, semiempirical, and mechanistic models

Malekjani

Jafari

2020

Comp Rev Food Sci Food Safe

128

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The encapsulation process has been utilized in the field of food technology to enhance the technofunctional properties of food products and the delivery of nutraceutical ingredients via food into the human body. The latter application is very similar to drug delivery systems. The inherent sophisticated nature of release mechanisms requires the utilization of mathematical equations and statistics to predict the release behavior during the time. The science of mathematical modeling of controlled release has gained a tremendous advancement in drug delivery in recent years. Many of these modeling methods could be transferred to food. In order to develop and design enhanced food controlled/targeted bioactive release systems, understanding of the underlying physiological and chemical processes, mechanisms, and principles of release and applying the knowledge gained in the pharmaceutical field to food products is a big challenge. Ideally, by using an appropriate mathematical model, the formulation parameters could be predicted to achieve a specific release behavior. So, designing new products could be optimized. Many papers are dealing with encapsulation approaches and evaluation of the impact of process and the utilized system on release characteristics of encapsulated food bioactives, but still, there is no deep insight into the mathematical release modeling of encapsulated food materials. In this study, information gained from the pharmaceutical field is collected and discussed to investigate the probable application in the food industry.

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“…Literature reports on PVAstabilized PCL microspheres loaded with flavonoid quercetin showed that all tested samples possessed a spherical morphology and wrinkled surface, but with large diameters, ranging between 61 and 171 µ m. Furthermore, the increase of quercetin entrapment efficiency induced the size enlargement of the quercetin-loaded species compared to their empty counterparts [59]. Spherical morphology has also been observed for curcuminloaded PHB/PVA micro-formulations exhibiting a semi smooth surface with pores of different sizes and mean diameters around 6.98 ± 1.89 µ m [60].…”

Section: Fesem Analysesmentioning

confidence: 73%

“…Furthermore, the increase of quercetin entrapment efficiency induced the size enlargement of the quercetin-loaded species compared to their empty counterparts [ 59 ]. Spherical morphology has also been observed for curcumin-loaded PHB/PVA micro-formulations exhibiting a semi smooth surface with pores of different sizes and mean diameters around 6.98 ± 1.89 µm [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…The obtained cell pellets were washed three times with sterile PBS (10 mM, pH 7.2) to separate the red blood cells (RBCs) from other blood components, such as the white blood cells, plasma proteins, and excess antibodies, centrifuged and finally re-suspended at 5 mL PBS. The hemolysis assay was performed by adding 100 µL of the RBC suspension to 900 µL of PBS, containing several concentrations (5,20,40,60,80,100,200, 300, 400, 500 µg•mL −1 ) of free chrysin, ChrPCL/PVAMCs, or ChrPHB/PVAMCs. The positive (+) control sample of hemolysis used (100% hemolysis) consisted of 900 µL of ultrapure water and 100 µL of washed RBCs.…”

Section: Hemocompatibility Studiesmentioning

confidence: 99%

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Evaluation of the Hemocompatibility and Anticancer Potential of Poly(ε-Caprolactone) and Poly(3-Hydroxybutyrate) Microcarriers with Encapsulated Chrysin

et al. 2021

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In this work, novel chrysin-loaded poly(ε-caprolactone) and poly(3-hydroxybutyrate) microcarriers were synthesized according to a modified oil-in-water single emulsion/solvent evaporation method, utilizing poly(vinyl alcohol) surfactant as stabilizer and dispersing agent for the emulsification, and were evaluated for their physico-chemical and morphological properties, loading capacity and entrapment efficiency and in vitro release of their load. The findings suggest that the novel micro-formulations possess a spherical and relatively wrinkled structure with sizes ranging between 2.4 and 24.7 µm and a highly negative surface charge with z-potential values between (−18.1)–(−14.1) mV. The entrapment efficiency of chrysin in the poly(ε-caprolactone) and poly(3-hydroxybutyrate) microcarriers was estimated to be 58.10% and 43.63%, whereas the loading capacity was found to be 3.79% and 15.85%, respectively. The average release percentage of chrysin was estimated to be 23.10% and 18.01%, respectively. The novel micromaterials were further biologically evaluated for their hemolytic activity through hemocompatibility studies over a range of hematological parameters and cytoxicity against the epithelial human breast cancer cell line MDA-MB 231. The poly(ε-caprolactone) and poly(3-hydroxybutyrate) microcarriers reached an IC50 value with an encapsulated chrysin content of 149.19 µM and 312.18 µM, respectively, and showed sufficient blood compatibility displaying significantly low (up to 2%) hemolytic percentages at concentrations between 5 and 500 µg·mL−1.

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Modeling the release of curcumin from microparticles of poly(hydroxybutyrate) [PHB]

Cited by 16 publications

References 26 publications

Fabrication and Characterization of Cinnamaldehyde-Loaded Mesoporous Bioactive Glass Nanoparticles/PHBV-Based Microspheres for Preventing Bacterial Infection and Promoting Bone Tissue Regeneration

Fabrication and Characterization of Cinnamaldehyde-Loaded Mesoporous Bioactive Glass Nanoparticles/PHBV-Based Microspheres for Preventing Bacterial Infection and Promoting Bone Tissue Regeneration

Modeling the release of food bioactive ingredients from carriers/nanocarriers by the empirical, semiempirical, and mechanistic models

Evaluation of the Hemocompatibility and Anticancer Potential of Poly(ε-Caprolactone) and Poly(3-Hydroxybutyrate) Microcarriers with Encapsulated Chrysin

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