Modeling synucleinopathies in rodents

Janer, Anna Barber; Vonck, Eline; Baekelandt, Veerle

doi:10.1016/bs.irmvd.2021.09.001

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Thy1-syn14 Mice Exhibit Progressive Motor Deficits1

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2023

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Cited by 3 publications

(2 citation statements)

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“…PD-like motor deficits were reported in different mouse models of the disease. 40 We assessed grip strength, hindlimb reflexes, and coordination/movement as measures of motor dysfunction in naive cohorts of 3-, 6-, and 13-month (M)-old mice. For hindlimb reflexes and coordination/movement assessments, we added the baseline results from our treatment cohort at 9 months of age (see below).…”

Section: Resultsmentioning

confidence: 99%

Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

Schmit,

Garcia,

Sciortino

et al. 2023

Cell Reports

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Section: Resultsmentioning

confidence: 99%

Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

Schmit,

Garcia,

Sciortino

et al. 2023

Cell Reports

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“…PD-like motor deficits have been reported in a variety of mouse models of the disease (reviewed in (Barber Janer, Vonck, and Baekelandt 2021)). Here we assessed for grip strength, hind limb reflexes and coordination/movement.…”

Section: Thy1-syn14 Mice Exhibit Progressive Motor Deficitsmentioning

confidence: 99%

Dietary fibre deprivation and bacterial curli exposure shift gut microbiome and exacerbate Parkinson's disease-like pathologies in an alpha-synuclein-overexpressing mouse

Schmit

Sciortino

Aho

et al. 2022

Preprint

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The microbiome-gut-brain axis has been proposed as a pathogenic path in Parkinson's disease (PD). Dietary driven dysbiosis and reduced gut barrier function could facilitate the interaction of toxic external or internal factors with the enteric nervous system, where PD could start. Amyloid bacterial protein such as curli can act as seed to corrupt enteric alpha-synuclein and lead to its aggregation. Misfolded alpha-synuclein can propagate to and throughout the brain. Here, we aimed at understanding if fibre deprivation and amyloidogenic protein curli could, individually or together, exacerbate the phenotype in both enteric and central nervous systems of a transgenic mouse overexpressing wild-type human alpha-synuclein. We analysed the gut microbiome, motor behaviour, gastrointestinal and brain pathologies in these mice. Our findings show that external interventions, akin to unhealthy life habits in humans, can exacerbate PD-like pathologies in mice. We believe that our results shed light on how lifestyle affects PD progression.

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Multifactor Progression of Parkinson's Disease: Role of Diet and Exposure to Microbiome-Borne Curli

et al. 2022

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Modeling synucleinopathies in rodents

Cited by 3 publications

References 252 publications

Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

Dietary fibre deprivation and bacterial curli exposure shift gut microbiome and exacerbate Parkinson's disease-like pathologies in an alpha-synuclein-overexpressing mouse

Multifactor Progression of Parkinson's Disease: Role of Diet and Exposure to Microbiome-Borne Curli

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