Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

Schmit, Kristopher J.; Garcia, Pierre; Sciortino, Alessia; Aho, Velma T.E.; Pardo Rodriguez, Beatriz; Thomas, Mélanie H.; Gérardy, Jean-Jacques; Bastero Acha, Irati; Halder, Rashi; Cialini, Camille; Heurtaux, Tony; Ostahi, Irina; Busi, Susheel B.; Grandmougin, Léa; Lowndes, Tuesday; Singh, Yogesh; Martens, Eric C.; Mittelbronn, Michel; Buttini, Manuel; Wilmes, Paul

doi:10.1016/j.celrep.2023.113071

Cited by 4 publications

(1 citation statement)

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“…A recent study investigated disease exacerbation in a transgenic PD mouse model resulting from fiber deprivation and exposure to bacterial curli. Examination of the intestinal microbiota, movement patterns, and gut and cerebral disorders revealed alterations induced by both diet and bacterial curli, which worsened motor performance as well as intestinal and brain issues to varying degrees . In a broader context, α-syn has been proposed to interact with both innate and adaptive immunity. , Inflammation is intricately connected to a cycle that encourages its expansion, a reactive setting boosts α-syn production, misconfiguration, and clumping. ,, This, in turn, triggers local proinflammatory immune responses .…”

Section: Gut Dysbiosis In Pdmentioning

confidence: 99%

Pesticides and the Gut Microbiota: Implications for Parkinson’s Disease

Ghosh,

Sinha,

Sil

2024

Chem. Res. Toxicol.

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Parkinson’s disease (PD) affects more people worldwide than just aging alone can explain. This is likely due to environmental influences, genetic makeup, and changes in daily habits. The disease develops in a complex way, with movement problems caused by Lewy bodies and the loss of dopamine-producing neurons. Some research suggests Lewy bodies might start in the gut, hinting at a connection between these structures and gut health in PD patients. These patients often have different gut bacteria and metabolites. Pesticides are known to increase the risk of PD, with evidence showing they harm more than just dopamine neurons. Long-term exposure to pesticides in food might affect the gut barrier, gut bacteria, and the blood–brain barrier, but the exact link is still unknown. This review looks at how pesticides and gut bacteria separately influence PD development and progression, highlighting the harmful effects of pesticides and changes in gut bacteria. We have examined the interaction between pesticides and gut bacteria in PD patients, summarizing how pesticides cause imbalances in gut bacteria, the resulting changes, and their overall effects on the PD prognosis.

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