Modeling of the drug delivery from a hydrophilic transdermal therapeutic system across polymer membrane

Иорданский, А. Л.; Feldstein, Mikhail M.; Markin, V. S.; Hadgraft, Jonathan; Platè, N.A.

doi:10.1016/s0939-6411(00)00063-1

Cited by 40 publications

(20 citation statements)

References 12 publications

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“…Often the transport mechanism in this type of systems does not behave according to Fickian diffusion. In fact, the results obtained in experimental context support the previous sentence ( [6], [10], [25], [31], [33], [34], [36], [37], see also [35] and the references contained in the last paper). However, often we find in the literature mathematical models for percutaneous drug absorption considering the system vehicle-skin established by using Fick's law (see e.g.…”

supporting

confidence: 87%

Coupled vehicle–skin models for drug release

Barbeiro

Ferreira

2009

Computer Methods in Applied Mechanics and Engineering

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Please cite this article as: S. Barbeiro, J.A. Ferreira, Coupled vehicle-skin models for drug release, Comput. Methods Appl. Mech. Engrg. (2009), doi: 10.1016/j.cma.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ACCEPTED MANUSCRIPT AbstractPercutaneous absorption of a drug delivered by a vehicle source is usually modeled by using diffusion Fick's law. In this case, the model consists in a system of partial differential equations of diffusion type with a compatibility condition on the transition boundary between the vehicle and the skin. Using this model, the fractional drug release in both componentsvehicle and skin -is proportional to the square root of the release time. Often experimental results show that the predicted drug concentration distribution in the vehicle and in the skin by the Fick's model does not agree with experimental data. In this paper we present a nonFickian mathematical model for the introduced percutaneous absorption problem. In this new model the Fick's law for the flux is modified by introducing a non-Fickian contribution defined with a relaxation parameter related to the properties of the components. Combining the flux equation with the mass conservation law, a system of integro-differential equations is established with a compatibility condition on the boundary between the two components of the physical model. The stability analysis is presented. In order to simulate the mathematical model, its discrete version is introduced. The stability and convergence properties of the discrete system are studied. Numerical experiments are also included.

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supporting

confidence: 87%

Coupled vehicle–skin models for drug release

Barbeiro

Ferreira

2009

Computer Methods in Applied Mechanics and Engineering

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“…This PVP-PEG400 PSA has been designed for enhanced transdermal delivery of drugs, is compatible with drugs of different physicochemical properties, does not act as a barrier to drug diffusion and is non-toxic [31][32][33]. We have decided to apply a hydrophilic PSA in order to keep the hydrophilic nature of the skin delivery system and because this type of adhesives offers several advantages over the hydrophobic ones: improved skin adhesion, compatibility with a higher variety of drugs and excipients, and expanded capability to control/manipulate adhesion-cohesive properties [34].…”

Section: Introductionmentioning

confidence: 99%

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Silva

Pereira

Ramalho

et al. 2008

Journal of Membrane Science

116

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a b s t r a c tNovel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pK a of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.The optimized film, including adhesive, has shown very good properties for application in the skin and represents a very promising formulation for further incorporation of drugs for topical and transdermal administration.

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“…The assessment of the release properties of TDS represents an important test for its pharmaceutical performance (42). The release experiment was carried out according to the FDA method (43).…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part I: Physicochemical Evaluation

et al. 2009

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Abstract. Management of moderate or severe chronic pain conditions is the burden of clinicians dealing with patients trying to improve their quality of life and diminish their suffering. Although not a new opioid, tramadol has been recently rediscovered and widely used; this may be due to its favorable chronic safety and dependence profiles together with its high potency. Tramadol is a centrally acting analgesic with half-life of~6 h; therefore, it requires frequent dosing. It is freely soluble in water; hence, judicious selection of retarding formulations is necessary. The current study is focused on the innovation of a novel, simple, monolayer, easy-to-use, cost-effective, and aesthetically acceptable bioadhesive transdermal delivery system overcoming the defects of the conventional "patch" as carrier system for tramadol, ensuring its adequate delivery, along with the physicochemical evaluation of the designed formulations. Monolithic tramadol matrix films of chitosan, different types of Eudragit ® , and binary mixtures of both were prepared. As a single-polymer film, chitosan film showed best properties except for somewhat high moisture uptake capacity, insufficient strength and rapid release, and permeation. Polymer blends were monitored in order to optimize both properties and performance. Promising results were obtained, with chitosan-Eudragit ® NE30D (1:1) film showing the most desirable combined, sufficiently rapid as well as prolonged release and permeation profiles along with satisfactory organoleptic and physicochemical properties.

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Modeling of the drug delivery from a hydrophilic transdermal therapeutic system across polymer membrane

Cited by 40 publications

References 12 publications

Coupled vehicle–skin models for drug release

Coupled vehicle–skin models for drug release

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part I: Physicochemical Evaluation

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