Modeling of the curing kinetics of an acrylic bone cement modified with hydroxyapatite

Mendizábal, Eduardo; Quiroz, Alicia; Olmos, M; Jasso, C. F.; Morejón, L.; Delgado, José Ángel García; Davidenko, Natalia

doi:10.1080/713743645

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…(1) and (2), which are for a first‐order reaction, do not adequately model the curing kinetics of an acrylic bone cement. In fact, a number of other models have been proposed,35, 36 but estimating the kinetic parameters from them using DSC data requires that the calorimeter be run in the isothermal mode. Furthermore, the DSC study performed in the present work was parametric in nature; that is, the interest was not in the values of the kinetic parameters (and hence c ′) per se but how these values (and hence c ′) change when one parameter (the activator in the acrylic bone cement) was changed, while all others remain the same.…”

Section: Resultsmentioning

confidence: 99%

Influence of the activator in an acrylic bone cement on an array of cement properties

Lewis

Deb

et al. 2006

J Biomedical Materials Res

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In all but one of the acrylic bone cement brands used in cemented arthroplasties, N,N‐dimethyl‐4‐toluidine (DMPT) serves as the activator of the polymerization reaction. However, many concerns have been raised about this activator, all related to its toxicity. Thus, various workers have assessed a number of alternative activators, with two examples being N,N‐dimethylamino‐4‐benzyl laurate (DMAL) and N,N‐dimethylamino‐4‐benzyl oleate (DMAO). The results of limited characterization of cements that contain DMAL or DMAO have been reported in the literature. The present work is a comprehensive comparison of cements that contain one of these three activators, in which the values of a large array of their properties were determined. These properties range from the setting time and maximum exotherm temperature of the curing cement to the variation of the loss elastic modulus of the cured cement with frequency of the applied indenting force in dynamic nanoindentation tests. The present results, taken in conjunction with those presented in previous reports by the present authors and co‐workers on other properties of these cements, indicate that both DMAL and DMPT are suitable alternatives to DMPT. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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Section: Resultsmentioning

confidence: 99%

Influence of the activator in an acrylic bone cement on an array of cement properties

Lewis

Deb

et al. 2006

J Biomedical Materials Res

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“…The second method involved use of a variant of a kinetics model, which is given by11, 21, 25, 27, 28 where α is the degree of conversion, α max is the maximum reaction conversion, and m and n are reaction order constants, while Z , Q , R , and T d retain their meanings, as in Eq. (2).…”

Section: Discussionmentioning

confidence: 99%

“…Four heating rates (5, 10, 15, and 20 K min −1 ) were used. (Since no consensus has emerged as to what heating rate should be used in DSC tests on acrylic bone cements, we decided to run the tests over the range of rates used in literature studies 9–11, 15, 22, 25, 27, 29…”

Section: Methodsmentioning

confidence: 99%

“…In a bid to increase the in vivo longevity of cemented arthroplasties and to address concerns about some of the aforementioned functional constituents, the viability of various modifications to the composition of commercially available acrylic bone cement brands has been investigated. Among these modifications are incorporation of a bioactive filler,9–11 a crosslinking agent,10 a biocompatibilizer,10 an oligomer filler,12 carbon nanotubes,13 an antimicrobial agent,14 and an antibiotic powder15; use of a new type of radiopacifier in place of BaSO 4 or ZrO 2 particles16, 17; use of a less toxic activator to replace DMPT18; a reduction in the relative amount of DMPT19, 20; and an increase in the amount of copolymer in the cement powder (for cement powders that contain a copolymer) 19, 20…”

Section: Introductionmentioning

confidence: 99%

“…A number of reports have appeared on the polymerization kinetics of acrylic bone cement9–11, 21–30; however, with the exception of incorporation of gentamicin sulfate powder15 and substitution of an iodine copolymer in the powder for BaSO 4 particles,17 the influence of many of the compositional changes suggested12–14, 16, 18–20 on k , has not been studied. Thus, it is the objective of the present study to delineate the influence of the following three compositional variables on k : the amount of copolymer as a proportion of the total powder weight (COP), the amount of DMPT as a proportion of the total volume of the liquid monomer (ACC), and the accelerator.…”

Section: Introductionmentioning

confidence: 99%

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Influence of changes in the composition of an acrylic bone cement on its polymerization kinetics

Lewis¹,

Mishra²

2006

J Biomed Mater Res

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It has been suggested in the literature that a lower polymerization rate of an acrylic bone cement is favorable for the in vivo longevity of a cemented arthroplasty. The present work was a study of the influence of three changes in the composition of an acrylic bone cement (when taken separately) on the cement polymerization rate at 37 degrees C (assumed to be the temperature in the bone bed during a cemented arthroplasty) [k']. The changes were the amount of copolymer as a proportion of the total powder weight (in cements in which there is a copolymer in the powder), the amount of DMPT as a proportion of the total volume of the liquid monomer, and the accelerator. k' was calculated using values of the activation energy and the frequency factor (assuming the polymerization reaction is Arrhenius in nature) that were computed from measurements made using the nonisothermal mode of differential scanning calorimetry. Statistical analysis (one-way ANOVA, with Bonferroni correction, and factorial ANOVA) of the k' values showed that the change in accelerator had a significant influence on k'. The importance of this finding, together with results from two relevant literature reports, is discussed within the context of the use of modified bone cements in cemented arthroplasties.

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Bone Cements: Acrylic

Jasso-Gastinel¹,

Alonso²,

Mendizábal³

2016

Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

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Modeling of the curing kinetics of an acrylic bone cement modified with hydroxyapatite

Cited by 4 publications

References 25 publications

Influence of the activator in an acrylic bone cement on an array of cement properties

Influence of the activator in an acrylic bone cement on an array of cement properties

Influence of changes in the composition of an acrylic bone cement on its polymerization kinetics

Bone Cements: Acrylic

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