This paper presents the results of Rainfall-Runoff modeling and simulation of hydrological responses under changing climate using HEC-HMS model. The basin spatial data was processed by HEC-GeoHMS and imported to HEC-HMS. The calibration and validation of the HEC-HMS model was done using the observed hydrometeorological data and HEC-GeoHMS output data. The goodness-of-fit of the model was measured using three performance indices: Nash and Sutcliffe coefficient (NSE) = 0.8, Coefficient of Determination (R 2 ) = 0.8, and Percent Difference (D) = 0.03, with values showing very good performance of the model. Finally, the optimized HEC-HMS model has been applied to simulate the hydrological responses of Upper Baro Basin to the projected climate change for mid-term (2040s) and long-term (2090s) A1B emission scenarios. The simulation results have shown a mean annual percent decrease of 3.6 and an increase of 8.1 for Baro River flow in the 2040s and 2090s scenarios, respectively, compared to the baseline period (2000s). A pronounced flow variation is rather observed on a seasonal basis, reaching a reduction of 50% in spring and an increase of 50% in autumn for both mid-term and long-term scenarios with respect to the base period. Generally, the rainfall-runoff model is developed to solve, in a complementary way, the two main problems in water resources management: the lack of gauged sites and future hydrological response to climate change data of the basin and the region in general. The study results imply that seasonal and time variation in the hydrologic cycle would most likely cause hydrologic extremes. And hence, the developed model and output data are of paramount importance for adaptive strategies and sustainable water resources development in the basin.