Modeling of diffusion controlled drug delivery

Siepmann, Juergen; Siepmann, Florence

doi:10.1016/j.jconrel.2011.10.006

Cited by 688 publications

(458 citation statements)

References 76 publications

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“…For example: there are low temperature and high temperature plasmas, as well as low-, high-and atmospheric-pressure plasmas [11]. As the cold low-pressure plasma offers many advantages for the treatment of polymers, especially PEEK, such as the low demand for the process gas, the lack of thermal stress on the polymer and the ability to handle also complex geometries [12], this technology is the most described in the literature [12], [27]. In this technique, the process gas is introduced into an evacuated chamber and from that a plasma is generated.…”

Section: Plasma Treatmentmentioning

confidence: 99%

“…Subsequently, it has been proposed that PEEK could display less stress-shielding effects when compared to conventionally applied dental and orthopedic implant materials such as titanium, demonstrating a much higher Young's modulus of 116 GPa [7]. Moreover, PEEK shows great biocompatibility in vitro and in vivo, causing neither toxic or mutagenic effects nor clinically significant inflammation [7], [8], [9], [10], [11], [12]. However, PEEK is biologically inert [13], [14], which has constrained its potential applications.…”

Section: Introductionmentioning

confidence: 99%

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Functionalization of polyethetherketone for application in dentistry and orthopedics

et al. 2017

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Abstract:Since late 1990s, polyetheretherketone (PEEK) has presented a promising polymeric alternative to metal implant components, particularly in orthopedic and traumatic applications. However, PEEK is biologically inert, which has constrained its potential applications. In this manner, enhancing the bioactivity of PEEK is a huge challenge that must be comprehended to completely understand the potential advantages. Up to now, two noteworthy methodologies are discussed to enhance the bioactivity of PEEK, including bulk and surface modification. Although the latter is extremely challenging due to the very high physical and chemical stability of the high performance polymer, there are some stated modification reactions in the literature, which will be collocated with in the literature-reported PEEK composites in the present article. We will furthermore add information on polymer-based drug delivery systems and the biofunctionalization of polymers in general and discuss their applicability for PEEK, as we estimate that these strategies will gain greater attention in the future. At the end of the article, our own research on the development of a PEEK-associated biodegradable drug-delivery system with potential application in dentistry or orthopedics will be highlighted.

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Section: Plasma Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functionalization of polyethetherketone for application in dentistry and orthopedics

et al. 2017

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“…For such objects the more complex models are used in the form of nonlinear algebraic or differential equations. These models consider such factors as the diffusion of a preparation [11], swelling, degradation and the erosion of polymers [12], percolation [13], including with the combined action. In order to calculate using the complicated models, a specialized computer application DDSolver was developed, which contains the library of models, the modules of nonlinear optimization and multidimensional statistical analysis [14].…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

Development of a bootstrap-model for determining the release of medicinal preparations in the human organism

Chorny¹,

Savyak²,

Kondratov

2017

EEJET

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“…Previously designed systems were applied in Franz cells (Franz, 1975) and Ussing chambers (Ussing, 1947). Nowadays there are several methods of determining drug transfer in biomedical systems (Siepmann and Siepmann, 2008;Siepmann and Siepmann, 2012). The classical diffusion chamber is built of two chambers (donor and acceptor ones) separated by a membrane or another mass transfer barrier.…”

Section: Introductionmentioning

confidence: 99%

Determination of diffusion coefficient and permeability through the barrier of substance in simulated biomedical systems

Adach

Kister

Skassa

et al. 2017

Chemical and Process Engineering

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The investigations deal with mass transfer in simulated biomedical systems. The modification of classical diffusion chamber, sequential unit (SU) system, imitated different biomedical setups, boundary conditions. The experiments simulated: diffusion chamber (also with two barriers), transport through the membrane to the blood stream, transport from the stent eluting drug simultaneously to the vessel cells and to the blood stream. The concentrations of substances and the relative mass increases/decreases for SU systems indicate that the order of the curves follows the order of mass transfer resistances. The strong dependence of mass transfer rates versus type of diffusing substance was confirmed. The calculated drug fluxes, diffusion coefficients, permeation coefficients are convergent with literature. Permeation coefficients for complex sequential systems can be estimated as parallel connexion of constituent coefficients. Experiments approved functionality of the SU for investigations in a simulated biomedical system. Obtained data were used for numerical verification.

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Modeling of diffusion controlled drug delivery

Cited by 688 publications

References 76 publications

Functionalization of polyethetherketone for application in dentistry and orthopedics

Functionalization of polyethetherketone for application in dentistry and orthopedics

Development of a bootstrap-model for determining the release of medicinal preparations in the human organism

Determination of diffusion coefficient and permeability through the barrier of substance in simulated biomedical systems

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