Modeling of closed-loop recycling dual-mode counter-current chromatography based on non-ideal recycling model

Kostanyan, A. E.; Galieva, Z.N.

doi:10.1016/j.chroma.2019.06.024

Cited by 13 publications

(13 citation statements)

References 40 publications

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“…The model has two additional parameters: b = V ec /V c -the ratio of the column volume V c and the volume of the recycling system V ec and N ec -the number of perfectly mixed cells characterizing the dispersion in the recycling system. To simulate the non-ideal CLR CCC processes, the following equation can be used [135,136]:…”

Section: Clr CCC Separations Using Recycling Systems With a Long Recymentioning

confidence: 99%

“…A common feature of the closed-loop recycling and dual mode CCC separations is the virtual column elongation, which allows for the multiple increase of the separation power of chromatographic columns. Recently [136,139], the method of CCC separations was proposed, which incorporates the advantages of both methods: separations are carried out in a countercurrent closed-loop recycling mode, including the periods of alternating recirculation of light and heavy phases. Fractions of separated compounds are withdrawn from the column with the phases after the periods of their recycling.…”

Section: Closed-loop Recycling Dual-mode CCC Separationsmentioning

confidence: 99%

“…Currently, a simpler version of this method has been developed and investigated, when, after the separation in the closed loop recycling mode and the elution of the separated compounds with the mobile x-phase through the one end of a column, the phases are reversed, and the remaining compounds are eluted with the mobile y-phase through the opposite end of the column. This CCC separation method is called closed-loop recycling dual mode countercurrent chromatography (CLR DM CCC) [136,139].…”

Section: Closed-loop Recycling Dual-mode CCC Separationsmentioning

confidence: 99%

“…Equations (5), (18), and (19) are easy to use in any standard computer program to design and simulate various options of CLR DM CCC. In [136], several examples of the separation of closely related compounds with low and high partition coefficients and complex mixtures containing closely related compounds with low and high partition coefficients are discussed and presented in the "Mathcad" program.…”

Section: Preparative and Industrial-scale Separationsmentioning

confidence: 99%

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Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

2020

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Countercurrent liquid-liquid chromatographic techniques (CCC), similar to solvent extraction, are based on the different distribution of compounds between two immiscible liquids and have been most widely used in natural product separations. Due to its high load capacity, low solvent consumption, the diversity of separation methods, and easy scale-up, CCC provides an attractive tool to obtain pure compounds in the analytical, preparative, and industrial-scale separations. This review focuses on the steady-state and non-steady-state CCC separations ranging from conventional CCC to more novel methods such as different modifications of dual mode, closed-loop recycling, and closed-loop recycling dual modes. The design and modeling of various embodiments of CCC separation processes have been described.

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Section: Clr CCC Separations Using Recycling Systems With a Long Recymentioning

confidence: 99%

Section: Closed-loop Recycling Dual-mode CCC Separationsmentioning

confidence: 99%

Section: Closed-loop Recycling Dual-mode CCC Separationsmentioning

confidence: 99%

Section: Preparative and Industrial-scale Separationsmentioning

confidence: 99%

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Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

2020

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“…Increasing the extra‐column volume (the recycling line length) caused a time delay of solute's retention but it improved the separation efficiency for CLR CCC process [86,87]. Similar studies were also conducted in closed‐loop recycling and dual‐mode CCC [88,89].…”

Section: Modeling the Dynamic Process Of Counter‐current Chromatographymentioning

confidence: 99%

Recent progress in separation prediction of counter‐current chromatography

Guo

Tong

Zhang

et al. 2020

J of Separation Science

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As a liquid‐liquid partition chromatography, counter‐current chromatography has advantages in large sample loading capacity without irreversible adsorption, which has been widely applied in separation and purification fields. The main factors, including partition coefficient, two‐phase solvent systems, apparatus, and operating parameters greatly affect the separation process of counter‐current chromatography. To promote the applications of counter‐current chromatography, it is essential to develop theoretical research to master the principles of counter‐current chromatographic separations so as to achieve predictions before laborious trials. In this article, recent progress about separation prediction methods are reviewed from a point of the steady and unsteady state of the mass transfer process of counter‐current chromatography and its mass transfer characteristics, and then it is divided into three aspects: prediction of partition coefficient, modeling the thermodynamic process of counter‐current chromatography, and modeling the dynamic process of counter‐current chromatography.

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The 10th international conference on countercurrent chromatography held at Technische Universität Braunschweig, Braunschweig, Germany, August 1–3, 2018

Jerz

Winterhalter

2020

Journal of Chromatography A

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Modeling of closed-loop recycling dual-mode counter-current chromatography based on non-ideal recycling model

Cited by 13 publications

References 40 publications

Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

Recent progress in separation prediction of counter‐current chromatography

The 10th international conference on countercurrent chromatography held at Technische Universität Braunschweig, Braunschweig, Germany, August 1–3, 2018

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