Modeling mass transfer and hydrodynamics in fluidized‐bed adsorption of proteins

Wright, Pamela R.; Glasser, Benjamin J.

doi:10.1002/aic.690470224

Cited by 44 publications

(42 citation statements)

References 28 publications

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“…The values of D p and k f for the three studied proteins varied from 1.24 × 10 −11 to 1.94 × 10 −11 m 2 /s and 11.28 × 10 −6 to 8.05 × 10 −6 m/s, respectively. These results are in the range of D p and k f values for macroporous particles reported in the literature [39,20,11,40]. According to Guiochon et al [41], film thickness and therefore mass transfer coefficient are determined by hydrodynamic conditions and depend on the liquid flow around the particle.…”

Section: Kinetic Of Adsorptionsupporting

confidence: 65%

Hydrophobic interaction adsorption of hen egg white proteins albumin, conalbumin, and lysozyme

Garcia‐Rojas

Coimbra

Minim

et al. 2006

Journal of Chromatography B

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Hydrophobic adsorption equilibrium data of the hen egg white proteins albumin, conalbumin, and lysozyme were obtained in batch systems, at 25 degrees C, using the Streamline Phenyl resin as adsorbent. The influence of three types of salt, NaCl, Na(2)SO(4), or (NH(4))(2)SO(4), and their concentration on the equilibrium data were evaluated. The salt Na(2)SO(4) showed the higher interaction with the studied proteins, thus favoring the adsorption of proteins by the adsorbent, even though each type of salt interacted in a distinct manner with each protein. The isotherm models of Langmuir, Langmuir exponential, and Chen and Sun were well fitted to the equilibrium data, with no significant difference being observed at the 5% level of significance. The mass transfer model applied simulated correctly adsorption kinetics of the proteins under the studied conditions.

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Section: Kinetic Of Adsorptionsupporting

confidence: 65%

Hydrophobic interaction adsorption of hen egg white proteins albumin, conalbumin, and lysozyme

Garcia‐Rojas

Coimbra

Minim

et al. 2006

Journal of Chromatography B

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“…Therefore, it will be more significant to research multi-component proteins competitive adsorption in an EBA process. Many authors have investigated single-component protein ion exchange rates in a fixed bed and in an EBA process (Alan and Carta, 2000;Bruce and Chase, 2001;Chen et al, 2003, Dziennik et al, 2005Kaczmarski et al, 2001;Li et al, 2004;Tong et al, 2003;Wright and Glasser, 2001), and some authors also have considered the case of multi-component proteins competitive adsorption in a fixed bed (Hubbuch et al, 2003;Lewus and Carta, 1999;Martin et al, 2005;Weinmrenner and Etzel, 1994), but few studies have been reported about protein competitive adsorption and desorption in an EBA process.…”

Section: Introductionmentioning

confidence: 98%

Expanded bed adsorption/desorption of proteins with Streamline Direct CST I adsorbent

Xiu²,

Mata³

et al. 2006

Biotech & Bioengineering

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Streamline Direct CST I is a new type of ion exchanger with multi-modal functional groups, specially designed for an expanded bed adsorption (EBA) process, which can capture directly the proteins from the high ionic strength feedstocks with a high binding capacity. In this study, an experimental study is carried out for two-component proteins (BSA and myoglobin) competitive adsorption and desorption in an expanded bed packed with Streamline Direct CST I. Based on the measurements of the single- and two-component bovine serum albumin (BSA)/myoglobin adsorption isotherm on Streamline Direct CST I, the binding and elution conditions for the whole EBA process are selected; and then frontal analysis for a longer timescale and column displacement experiments in a fixed bed (XK16/20 column) are carried out to evaluate the two-component proteins (BSA and myoglobin) competitive adsorption and displacement on Streamline Direct CST I. Finally, the feasibility of capturing both BSA and myoglobin by an expanded bed packed with Streamline Direct CST I is addressed in a Streamline 50 column packed with 300 mL Streamline Direct CST I.

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“…The flow structures in the lab-based fluidized beds were complex [12,13] and accurate quantification of these flow structures needed to be obtained in a wide range of time and expenses scales by experimental methods [14][15][16][17][18]. In the last few years, computational fluid dynamics (CFD) has been developed to understand such intricacies because it is more flexible than experimental studies and less expensive, and it allowed process engineers to predict, manipulate, and realize the desired fluid dynamics in process equipment [19,20], which was complementary to experimental methods with the onset of better computational and experimental facilities [14,[21][22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Development of a novel mobile industrial-scale fluidized adsorption process for emergency treatment of water polluted by aniline: CFD simulation and experiments

Zheng

Cao

et al. 2016

Advanced Powder Technology

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a b s t r a c tThis study developed a novel mobile industrial-scale fluidized adsorption process and preliminarily explored its application in the emergency water treatment. A lab-based Liquid-Solid Circulating Fluidized Bed (LSCFB) was prepared and the flow pattern was studied by validated computational fluid dynamics (CFD) models. The simulation results revealed that the particular uneven flow structure, which could weaken aniline removal performance, occurred with increasing superficial liquid velocity. Accordingly, an optimized distributor design was constructed by the established CFD models; notably, the effect of open angles on the flow pattern, which was often overlooked by previous studies, was mainly discussed. Then, the aniline removal efficiency of LSCFB pre and post optimization was compared. The experimental results demonstrate that dynamic adsorption capacity on aniline reached 70 mg/g under the optimum conditions (initial aniline concentration of 100 mg/L, superficial liquid velocity of 3u mf and sorbent dosage of 27 g/L). By comparison with fixed-bed adsorption, the LSCFB possessed significantly higher adsorption rate constants and shorter hydraulic retention time, which indicates that LSCFB could meet emergency treatment requirements in a better way. Finally, the study developed the mobile industrial-scale fluidized adsorption process and estimated process parameters for aniline removal in the Sudden Water Pollution Accident of Zhuozhang River.

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Modeling mass transfer and hydrodynamics in fluidized‐bed adsorption of proteins

Cited by 44 publications

References 28 publications

Hydrophobic interaction adsorption of hen egg white proteins albumin, conalbumin, and lysozyme

Hydrophobic interaction adsorption of hen egg white proteins albumin, conalbumin, and lysozyme

Expanded bed adsorption/desorption of proteins with Streamline Direct CST I adsorbent

Development of a novel mobile industrial-scale fluidized adsorption process for emergency treatment of water polluted by aniline: CFD simulation and experiments

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