Modeling and simulation of carbon nanotube-based dual-gated enzyme field effect transistor for acetylcholine detection

Sharma, Purnima Kumari; Thakur, Hiranya Ranjan; Dutta, Jiten Chandra

doi:10.1007/s10825-017-0992-9

Cited by 10 publications

(8 citation statements)

References 34 publications

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“…Therefore, researchers are working to design the infrastructure, circuits, processes and interconnections. [ 44–46 ] To date, CNT thin‐film FETs have been intensively studied in multiple application areas, including several basic logic and storage devices, [ 47–53 ] synaptic devices, [ 54–57 ] healthcare devices, [ 58,59 ] radio frequency technology, [ 60,61 ] biosensing and detection technology, [ 62–65 ] communication engineering, [ 66,67 ] electrical applications, such as compressor, [ 68 ] ultralow power device, [ 69 ] AC amplifier, [ 70 ] and display electronics, [ 71 ] and so on. In the case of TCAM, as far as we know, the hybrid method of making TCAM has not been tried.…”

Section: Introductionmentioning

confidence: 99%

Inverter and Ternary Content‐Addressable Memory Based on Carbon Nanotube Transistors Using Chemical Doping Strategy

Yuan

Wang

et al. 2022

Adv Elect Materials

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Carbon nanotubes (CNTs) have attracted much attention in transistors because of their unique structure and electrical properties. However, the implementation of transistor polarity control and complementary logic functions remains a key challenge. In this work, the polarity of carbon nanotube transistors using chemical doping strategy is modulated. By triethyl oxonium hexachloro antimonate doping and polyethylene imine doping with chemically modified, p‐type CNTs and n‐type CNTs as the transistor channel of the bottom gate structure field effect transistors are prepared. An inverter is constructed by connecting p‐type transistor and n‐type transistor in series. The inverter has a voltage hysteresis window and gain over 20.5. A Schmitt trigger with operating frequency over 2 MHz is built based on high‐low conversion of inverter output voltage during dual‐scan has different threshold voltage characteristics. Two inverters are used to construct a ternary content‐addressable memory cell with four transistors, which has an on/off ratio up to 104, a data retention characteristic of 104 s, and a good stability of more than 1000 cycles, indicating the great potential of practical application in future computing‐in memory.

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Section: Introductionmentioning

confidence: 99%

Inverter and Ternary Content‐Addressable Memory Based on Carbon Nanotube Transistors Using Chemical Doping Strategy

Yuan

Wang

et al. 2022

Adv Elect Materials

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“…ACh is involved in the chemical transmission at synapses and performs functions such as regulating other neurotransmitters, controlling the opening of ligand-gated ion channels, and facilitating bursts of neuronal firing . Imbalances of ACh levels have been linked to Alzheimer’s disease, myasthenia gravis, as well as behavioral, learning, and sleep disorders. − Enzymatic detection of ACh has been achieved by the sequential use of acetylcholinesterase and choline oxidase to generate hydrogen peroxide from ACh. − ACh quantification is then achieved by electrochemical or optical detection of the hydrogen peroxide, , but other methods have also been used. − ACh has also been detected using a nickel anode electrode and electrodes that were modified with only acetylcholinesterase. − So far, all of these have been carried out at micro- and macroscales.…”

Section: Introductionmentioning

confidence: 99%

Detection of Acetylcholine at Nanoscale NPOE/Water Liquid/Liquid Interface Electrodes

et al. 2021

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The interface between two immiscible electrolyte solutions (ITIES) has become a very powerful analytical platform for sensing a diverse range of chemicals (e.g., metal ions and neurotransmitters) with the advantage of being able to detect nonredox electroactive species. The ITIES is formed between organic and aqueous phases. Organic solvent identity is crucial to the detection characteristics of the ITIES [half-wave transfer potential (E 1/2 ), potential window range, limit of detection, transfer coefficient (α), standard heterogeneous ion-transfer rate constant (k 0 ), etc.]. Here, we demonstrated, for the first time at the nanoscale, the detection characteristics of the NPOE/water ITIES. Linear detection of the diffusion-limited current at different concentrations of acetylcholine (ACh) was demonstrated with cyclic voltammetry (CV) and i−t amperometry. The E 1/2 of ACh transfer at the NPOE/water nanoITIES was −0.342 ± 0.009 V versus the E 1/2 of tetrabutylammonium (TBA + ). The limit of detection of ACh at the NPOE/water nanoITIES was 37.1 ± 1.5 μM for an electrode with a radius of ∼127 nm. We also determined the ion-transfer kinetics parameters, α and k 0 , of TBA + at the NPOE/water nanoITIES by fitting theoretical cyclic voltammograms to experimental voltammograms. This work lays the basis for future cellular studies using ACh detection at the nanoscale and for studies to detect other analytes. The NPOE/water ITIES offers a potential window distinct from that of the 1,2-dichloroethane (DCE)/water ITIES. This unique potential window would offer the ability to detect analytes that are not easily detected at the DCE/water ITIES.

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“…The DG ISFET is significantly improved in terms of sensitivity, signal-to-noise ratio, drift rate and hysteresis. This will play a strong role in promoting medical testing, environmental protection and industrial production [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Design and Implementation of a pH Sensor for Micro Solution Based on Nanostructured Ion-Sensitive Field-Effect Transistor

Wang

Yang

2020

Sensors

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pH sensors based on a nanostructured ion-sensitive field-effect transistor have characteristics such as fast response, high sensitivity and miniaturization, and they have been widely used in biomedicine, food detection and disease monitoring. However, their performance is affected by many factors, such as gate dielectric material, channel material and channel thickness. In order to obtain a pH sensor with high sensitivity and fast response, it is necessary to determine the appropriate equipment parameters, which have high processing cost and long production time. In this study, a nanostructured ion-sensitive field-effect transistor was developed based on the SILVACO technology computer-aided design (TCAD) simulator. Through experiments, we analyzed the effects of the gate dielectric material, channel material and channel thickness on the electrical characteristics of the nanostructured field-effect transistor. Based on simulation results, silicon nitride was selected as the gate dielectric layer, while indium oxide was chosen as the channel layer. The structure and parameters of the dual channel ion-sensitive field-effect transistor were determined and discussed in detail. Finally, according to the simulation results, a pH sensor based on the nanostructured ion-sensitive field-effect transistor was fabricated. The accuracy of simulation results was verified by measuring the output, transfer and pH characteristics of the device. The fabricated pH sensor had a subthreshold swing as low as 143.19 mV/dec and obtained an actual sensitivity of 88.125 mV/pH. In addition, we also tested the oxidation reaction of hydrogen peroxide catalyzed by horseradish peroxidase, and the sensitivity was up to 144.26 pA mol−1 L−1, verifying that the ion-sensitive field-effect transistor (ISFET) can be used to detect the pH of micro solution, and then combine the enzyme-linked assay to detect the concentration of protein, DNA, biochemical substances, biomarkers, etc.

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Modeling and simulation of carbon nanotube-based dual-gated enzyme field effect transistor for acetylcholine detection

Cited by 10 publications

References 34 publications

Inverter and Ternary Content‐Addressable Memory Based on Carbon Nanotube Transistors Using Chemical Doping Strategy

Inverter and Ternary Content‐Addressable Memory Based on Carbon Nanotube Transistors Using Chemical Doping Strategy

Detection of Acetylcholine at Nanoscale NPOE/Water Liquid/Liquid Interface Electrodes

Design and Implementation of a pH Sensor for Micro Solution Based on Nanostructured Ion-Sensitive Field-Effect Transistor

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