Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

Abstract

There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This “reverse translational” approach needs to be supported by continuing efforts to refine the in silico tools that allow extrapolation of results between species.

CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies

“…Canines have long been used for the preclinical testing of human cell therapies and represent an attractive spontaneous disease model to study innovative CAR T cell strategies and to develop novel off-the-shelf approaches. In return, information on CAR T cell efficacy and safety from human clinical trials can guide the development of future cell-based therapies in veterinary oncology, under the so-called One Health initiative (65). Preliminary data in dogs using a canine CD 20-specific CAR in expanded T cells showed promising, but transient results.…”

“…According to a recent report from the National Academy of Medicine (64), only one out of ten oncology candidates that appear promising in preclinical mouse models are in fact effective and safe in human clinical trials. This overtly high attrition rate highlights the need for alternative models at the early stage of the Drug Research and Development lifecycle (65), as shown in other therapeutic areas (66)(67)(68)(69)(70)(71).…”

“…The opportunity to synergize quantitative information available from humans and animals sharing clinical analogs to develop improved therapies for both species is known as Breverse translation^ (65). A significant component of the success of comparative oncology in drug development is the creation of consortia that link drug development stakeholders to veterinary clinicians with access to tumor-bearing pet animals.…”

Cannabis, One Health, and Veterinary Medicine: Cannabinoids’ Role in Public Health, Food Safety, and Translational Medicine

“…1 From this perspective, a better, "One Health" model for drug testing might be found in animals with naturally occurring diseases, treated as a part of their life routine, in the same environment as humans, allowing for the simultaneous development of drugs for human and animal patients, thereby reducing time to development of drugs for humans, reducing associated costs, and contributing to animal welfare. 2…”

Reverse Translational Pharmacology Research Is Driven by Big Data

“…In this special issue of Reverse Translational Research in CPT: Pharmacometrics & System Pharmacology , we further illustrate the challenges and opportunities in various specific pharmacology research areas. Schneider et al . discussed the reverse translational research between veterinary and human medicine; system pharmacology studies in pregnant women by Quinney et al .…”