Mode of Presentation of Invasive Bladder Cancer: Reassessment of the Problem

Kaye, Keith W.; Lange, Paul H.

doi:10.1016/s0022-5347(17)52738-x

Cited by 119 publications

(44 citation statements)

References 11 publications

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“…This is evident clinically as only a small proportion of patients with superficial bladder tumor had been observed to progress to invasive disease while the majority of patients with muscle-invasive cancer had reached this stage at initial clinical presentation. 13,14 This invasive behavior may be related to environmental or host factors through the process of initiation and promotion that determines the course of proliferation and hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

The Clinicopathological Features of Bladder Carcinoma Among Saudis in Riyadh Central Hospital

Kattan

Yousef

Onuora

et al. 1994

Annals of Saudi Medicine

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In a retrospective study, the records of 54 Saudi patients constituting 35.2% of the total number of patients with bladder carcinoma presenting to Riyadh Central Hospital over a seven year period (1985G to 1992G) were reviewed. Eighty-one percent of the patients were habitants of the Central Province of Saudi Arabia. Their mean age was 60 ± 14.8 years. Male to female ratio was 5:1; gross hematuria was the main presenting symptom, occurring in 90% of patients. Twenty-four patients presented six months or more after the onset of symptoms. Upper tract deterioration was noted in 50% of cases at the time of initial presentation. A total of 76.9% of bladder tumors were transitional cell carcinoma, 19.2% were squamous cell carcinoma and 3.8% were poorly differentiated. Only 29% were superficial tumors while 71% were at least muscle-invading at presentation. The majority of tumors were of high grade. This study shows that high grade muscle-invading transitional cell carcinoma is the most frequent histological pattern of bladder tumor in Riyadh Central Hospital. Delay in patient presentation associated with a tendency for invasion of bladder tumor in this region resulted in a high percentage of incurable disease.

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Section: Discussionmentioning

confidence: 99%

The Clinicopathological Features of Bladder Carcinoma Among Saudis in Riyadh Central Hospital

Kattan

Yousef

Onuora

et al. 1994

Annals of Saudi Medicine

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“…19 At their initial presentation, 57% of patients had de novo muscle-invasive disease. These data were compared with older series from the early 1980s by Kaye and Lange 20 and Hopkins et al, 21 which found rates of de 22 Among the 87,978 cases, the stage at diagnosis did not change significantly. In situ (Ta and Tis) cancer incidence increased by 1% per year; local disease (T1, T2a, T2b) incidence decreased by 1% annually; and advanced disease (T3a, T3b, T4, nodal and distant metastases) incidence decreased by 0.74%.…”

Section: Discussionmentioning

confidence: 87%

Surveillance of urothelial carcinoma

David

Mallin

Milowsky

et al. 2009

Cancer

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BACKGROUND: Previous investigators have detected shifts to lower stages at diagnosis for renal cell carcinoma and prostate cancer. The authors investigated whether a similar pattern is seen for urothelial carcinomas of the bladder, ureter, and renal pelvis and sought to identify changes in cancer grade and survival trends from 1993 to 2005. METHODS: The National Cancer Data Base (NCDB) collects data on approximately 75% of all newly diagnosed cancer cases annually. The authors queried the database for cases of urothelial carcinomas diagnosed in 1993‐2005 in patients aged 18 years and older. All cancer stage data were forward converted to the sixth edition of the American Joint Committee on Cancer staging definitions. RESULTS: A total of 334,480 bladder cancer cases, 15,105 renal pelvis cancer cases, and 10,128 ureteral carcinoma cases were identified. Stage data were available for 84% of bladder cases, 83% of renal pelvis cases, and 82% of ureter cases. With the classification of early stage tumors as stage 0a, 0is, and I and late stage tumors as II, III, and IV, the percentage of early stage renal pelvis and ureter tumors increased slightly from 1993 to 2005, whereas no stage migration was seen in bladder tumors. In looking specifically at early stage tumors, a significant increase in the proportion of stage 0a and a significant decrease in the proportion of stage I tumors for each cancer site was seen between 1993 and 2005. The proportion of high grade tumors in each disease site significantly increased from 1993 to 2005. For cases diagnosed in 1993‐1996 and 1997‐2000, a significant decrease in 5‐year relative survival was observed for patients with stage I and stage II bladder cancer. The absolute change, however, was relatively small, and for bladder cases was not significantly different when adjusted for low or high grade tumors. CONCLUSIONS: When differentiating between early and late stage tumors, a slight stage migration was seen in renal pelvis and ureteral carcinomas, whereas no stage migration was seen in bladder tumors. Within early stage tumors of all sites, a stage shift was seen, most notably with the proportion of stage 0a tumors increasing and stage I tumors decreasing. The proportion of high grade tumors in all sites increased. No change in overall survival was observed, underscoring the need for new therapeutic advances. Cancer 2009. © 2009 American Cancer Society.

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“…The mean profile area of the 10 largest nuclei (MNA-10) found in a histological tumour section [8][9][10][11] has proved to be valuable as an independent marker for grade and prognosis. 12 In the study of Blomjous et al, 12 DNA diploid or DNA aneuploid cases (measured by flow cytometry) had nearly the same survival as MNA-10 low (< 95 µm 2 ) and MNA-10 high (> 95 µm 2 ) T A,1 tumours, respectively. Thus, it is tempting to speculate that high MNA-10 values are strongly predictive of DNA aneuploidy, which may be understandable from a cell biological point of view-many studies have shown that nuclear area strongly correlates with DNA content; thus, aneuploid cells often have larger nuclei.…”

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confidence: 95%

Improved objectivity of grading of TA,1 transitional cell carcinomas of the urinary bladder by quantitative nuclear and proliferation related features

Bol¹,

Baak²,

Bruin³

et al. 2001

Journal of Clinical Pathology

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Aim-To analyse whether the mean nuclear area of the 10 largest nuclei (MNA-10), the mitotic activity index (MAI), and Ki-67 immunoquantitative features have additional value to discriminate diVerent grades of T A,1 transitional cell carcinoma (TCC) of the urinary bladder. Materials/Methods-One hundred and fifty of 200 consecutive cases (75%) showing interobserver agreement on duplicate blind grade assessment by independent pathologists were studied. Using random numbers, the 150 cases were divided into sets for learning (n = 75) and testing (n = 75). Single and multivariate analyses were applied to discriminate the diVerent grades in the learning set. The multivariate classifier developed in this way was evaluated in the test set (n = 75). Results-With

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Mode of Presentation of Invasive Bladder Cancer: Reassessment of the Problem

Cited by 119 publications

References 11 publications

The Clinicopathological Features of Bladder Carcinoma Among Saudis in Riyadh Central Hospital

The Clinicopathological Features of Bladder Carcinoma Among Saudis in Riyadh Central Hospital

Surveillance of urothelial carcinoma

Improved objectivity of grading of TA,1 transitional cell carcinomas of the urinary bladder by quantitative nuclear and proliferation related features

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