Mode of Integration of Epstein-Barr Virus Genome into Host DNA in Burkitt Lymphoma Cells

Koliais, S. I.

doi:10.1099/0022-1317-44-2-573

Cited by 5 publications

(2 citation statements)

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“…EBV infects two main cell types, B lymphocytes and epithelial cells. The first reports on the possible integration of the EBV genome into human chromosomes date back to the mid-to late 1970s (3,4,50,54,89,104). At that time, the conclusion that EBV was integrated was derived mostly from isopycnic centrifugation experiments.…”

Section: Epstein-barr Virusmentioning

confidence: 99%

Herpesviruses and Chromosomal Integration

Morissette

Flamand

2010

J Virol

203

164

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Herpesviruses are members of a diverse family of viruses that colonize all vertebrates from fish to mammals. Although more than one hundred herpesviruses exist, all are nearly identical architecturally, with a genome consisting of a linear double-stranded DNA molecule (100 to 225 kbp) protected by an icosahedral capsid made up of 162 hollow-centered capsomeres, a tegument surrounding the nucleocapsid, and a viral envelope derived from host membranes. Upon infection, the linear viral DNA is delivered to the nucleus, where it circularizes to form the viral episome. Depending on several factors, the viral cycle can proceed either to a productive infection or to a state of latency. In either case, the viral genetic information is maintained as extrachromosomal circular DNA. Interestingly, however, certain oncogenic herpesviruses such as Marek's disease virus and Epstein-Barr virus can be found integrated at low frequencies in the host's chromosomes. These findings have mostly been viewed as anecdotal and considered exceptions rather than properties of herpesviruses. In recent years, the consistent and rather frequent detection (in approximately 1% of the human population) of human herpesvirus 6 (HHV-6) viral DNA integrated into human chromosomes has spurred renewed interest in our understanding of how these viruses infect, replicate, and propagate themselves. In this review, we provide a historical perspective on chromosomal integration by herpesviruses and present the current state of knowledge on integration by HHV-6 with the possible clinical implications associated with viral integration.

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Section: Epstein-barr Virusmentioning

confidence: 99%

Herpesviruses and Chromosomal Integration

Morissette

Flamand

2010

J Virol

203

164

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“…Or, ce phénomène d'intégration, également rencontré dans des lésions tumorales associées à d'autres herpesvirus tel le virus de la maladie de Marek ou le virus Epstein-Barr, n'a pas retenu l'attention de la communauté scientifique [46,47]. La renaissance et l'explosion de l'intérêt des chercheurs pour cette intégration chromosomique est récente avec la mise en évidence par hybridation in situ, par Daibata et al en 1998 [48], de séquences d'ADN de HHV-6 dans la région 44 du bras long du chromosome 1 d'une patiente atteinte de leucémie aiguë lymphoblastique, mais également chez l'un de ses fils et [49].…”

Section: Aspect Particulier : L'intégration Chromosomique Découverte unclassified