Molecular Biology of EBV in Relationship to AIDS-Associated Oncogenesis

Bajaj, Bharat; Murakami, Masanao; Robertson, Erle S.

doi:10.1007/978-0-387-46816-7_5

Cited by 21 publications

(34 citation statements)

References 132 publications

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“…1 Once a person is infected with EBV, the virus remains latent, mainly in B lymphocytes, for the lifetime of the infected host. 1 The EBV genome is 184 Kb of linear, double stranded DNA, which is maintained in the nucleus as an episome via tethering to the host cell chromosome after infection. 1 Primary exposure of EBV, which occurs during infancy, is usually asymptomatic.…”

Section: Tumor Virusesmentioning

confidence: 99%

“…1 The EBV genome is 184 Kb of linear, double stranded DNA, which is maintained in the nucleus as an episome via tethering to the host cell chromosome after infection. 1 Primary exposure of EBV, which occurs during infancy, is usually asymptomatic. However, when a person is first infected with EBV during adolescence, it usually results in a clinical condition known as infectious mononucleosis (IM).…”

Section: Tumor Virusesmentioning

confidence: 99%

“…However, when a person is first infected with EBV during adolescence, it usually results in a clinical condition known as infectious mononucleosis (IM). 1 EBV has powerful transforming potential for B lymphocytes in vitro and thus contributes to the development of numerous acute diseases and cancers, such as Burkitt lymphoma, nasopharyngeal carcinoma, natural killer cell lymphoma, Hodgkin disease and X-linked lymphoproliferative disease. 1 Moreover, immunocompromised patients including AIDS or post-organ transplant patients, also have a high probability of obtaining EBV associated lymphomas.…”

Section: Tumor Virusesmentioning

confidence: 99%

“…1 Moreover, immunocompromised patients including AIDS or post-organ transplant patients, also have a high probability of obtaining EBV associated lymphomas. 1 …”

Section: Tumor Virusesmentioning

confidence: 99%

See 3 more Smart Citations

Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention

Saha¹,

Kaul²,

Murakami³

et al. 2010

Cancer Biology & Therapy

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109

111

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Tumor viruses have provided relatively simple genetic systems, that can be manipulated for understanding the molecular mechanisms of the cellular transformation process. A growing body of information in the tumor virology field provides several prospects for rationally targeted therapies. However, further research is needed to better understand the multiple mechanisms utilized by these viruses in cancer progression in order to develop therapeutic strategies. Initially viruses were believed to be associated with cancers as causative agents only in animals. It was almost half a century before the first human tumor virus, Epstein-Barr virus (EBV), was identified in 1964. Subsequently, several human tumor viruses have been identified including Kaposi sarcoma associated herpesvirus (KSHV), human papillomaviruses (HPV), hepatitis B virus (HBV), Hepatitis C virus (HCV), human T lymphotropic virus (HTLV-1) and recently identified Merkel cell polyomavirus (MCPyV). Tumor viruses are sub-categorized as either DNA viruses, which include EBV, KSHV, HPV, HBV and MCPyV or RNA viruses such as HCV and HTLV-1. Tumor-viruses induce oncogenesis through manipulating an array of different cellular pathways. These viruses initiate a series of cellular events, which lead to immortalization and proliferation of the infected cells by disrupting the mitotic checkpoint upon infection of the host cell. This is often accomplished by functional inhibition or proteasomal degradation of many tumor suppressor proteins by virally encoded gene products. The virally infected cells can either be eliminated via cell-mediated apoptosis or persist in a state of chronic infection. Importantly, the chronic persistence of infection by tumor viruses can lead to oncogenesis. This review discusses the major human tumor associated viruses and their ability to modulate numerous cell signaling pathways, which can be targeted for potential therapeutic approaches.

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Section: Tumor Virusesmentioning

confidence: 99%

Section: Tumor Virusesmentioning

confidence: 99%

Section: Tumor Virusesmentioning

confidence: 99%

“…1 Moreover, immunocompromised patients including AIDS or post-organ transplant patients, also have a high probability of obtaining EBV associated lymphomas. 1 …”

Section: Tumor Virusesmentioning

confidence: 99%

See 2 more Smart Citations

Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention

Saha¹,

Kaul²,

Murakami³

et al. 2010

Cancer Biology & Therapy

Self Cite

109

111

View full text Add to dashboard Cite

show abstract

“…Infection is nonsymptomatic in healthy individuals, but has been associated with a number of lymphoproliferative disorders when accompanied by immunosuppression. Like all herpesviruses, EBV has both latent and lytic replication programs, which allows it to evade immune clearance and persist for the lifetime of the host (Bajaj et al, 2001). The most common primary symptoms of EBV infection are fever, skin eruption, lymphadenopathy, hepatosplenomegaly, eyelid edema, pharyngitis, cardiac arrhythmia and arthralgia (Li et al 2004;C.…”

Section: Epstein-bar Virus Infectionmentioning

confidence: 99%