Mode of action studies of a new desensitizing mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride

Mello, Sarita V.; Arvanitidou, Evangelia; Stranick, Michael; Santana, Ramon; Kutes, Yasemin; Huey, Bryan D.

doi:10.1016/j.jdent.2012.11.001

Cited by 19 publications

(7 citation statements)

References 22 publications

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“…For the purposes of evaluating this new desensitizing formulation, the Investigators used a dentine disc methodology to determine the effectiveness of a number of commercially available oral rinses in reducing fluid flow through tubular occlusion. The zinc substituted HA was included to compare the effectiveness of a commercially available oral rinse: both the arginine and PVM/MA copolymer and 1.4% potassium oxalate oral rinses have been reported to be effective in reducing DH and were used as positive controls [10, 11, 13, 14] and the potassium nitrate oral rinse was included as a negative control as its mode of action is generally considered to be by nerve desensitization rather than by tubular occlusion. In order to test the potential ability of a desensitizing product prior to clinical evaluation, in vitro and/or in situ studies are often conducted in order to determine a possible mode of action of the product.…”

Section: Discussionmentioning

confidence: 99%

In VitroAbility of a Novel Nanohydroxyapatite Oral Rinse to Occlude Dentine Tubules

Hill

Chen

Gillam

2015

International Journal of Dentistry

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Objectives. The aim of the study was to investigate the ability of a novel nanohydroxyapatite (nHA) desensitizing oral rinse to occlude dentine tubules compared to selected commercially available desensitizing oral rinses. Methods. 25 caries-free extracted molars were sectioned into 1 mm thick dentine discs. The dentine discs (n = 25) were etched with 6% citric acid for 2 minutes and rinsed with distilled water, prior to a 30-second application of test and control oral rinses. Evaluation was by (1) Scanning Electron Microscopy (SEM) of the dentine surface and (2) fluid flow measurements through a dentine disc. Results. Most of the oral rinses failed to adequately cover the dentine surface apart from the nHa oral rinse. However the hydroxyapatite, 1.4% potassium oxalate, and arginine/PVM/MA copolymer oral rinses, appeared to be relatively more effective than the nHA test and negative control rinses (potassium nitrate) in relation to a reduction in fluid flow measurements. Conclusions. Although the novel nHA oral rinse demonstrated the ability to occlude the dentine tubules and reduce the fluid flow measurements, some of the other oral rinses appeared to demonstrate a statistically significant reduction in fluid flow through the dentine disc, in particular the arginine/PVM/MA copolymer oral rinse.

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Section: Discussionmentioning

confidence: 99%

In VitroAbility of a Novel Nanohydroxyapatite Oral Rinse to Occlude Dentine Tubules

Hill

Chen

Gillam

2015

International Journal of Dentistry

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“…The hypothesis of the tooth protective effect of arginine‐containing products has been proposed for many years. Many clinical studies have shown that Pro‐Argin toothpaste (8% arginine, calcium carbonate and 1450 ppm fluoride, Colgate‐Palmolive Company, USA) or Pro‐Argin mouthwash (0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride) can effectively treat dentine hypersensitivity by blocking the dentinal tubules . It has been suggested that the positively charged guanidinium group of arginine interacts with the negatively charged groups on dentine surface such as fluoride ions, promoting the deposition of calcium and phosphorus in the dentinal tubules from saliva, thereby occluding dentine tubules and reducing fluid flow .…”

Section: Introductionmentioning

confidence: 99%

Arginine promotes fluoride uptake into artificial carious lesionsin vitro

Xing

Zhou

et al. 2015

Aust Dent J

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Background: This study focused on the interaction of arginine and fluoride on the remineralization of artificial enamel carious lesions in vitro. Methods: Human enamel blocks with artificial carious lesions were prepared and randomly divided into six treatment groups (n = 30 for each group): deionized water, arginine solution, NaF solution, arginine/NaF solution, arginine-free fluoride toothpaste slurry and arginine-containing fluoride toothpaste slurry. After a pH-cycling regimen for 10 days, subsets of specimens from each group were subjected to independent analysis, including surface microhardness (n = 8/30), cross-sectional microhardness (n = 8/30), enamel fluoride uptake (n = 8/30) and polarized light microscopy (n = 6/30). The samples tested for surface microhardness were further subjected to simulated plaque acid challenge before surface microhardness was remeasured. Results: Arginine solution promoted remineralization compared with deionized water control (p < 0.05). When used in combination with fluoride, arginine significantly increased fluoride uptake compared with fluoride alone (p < 0.05). In addition, lesions treated with arginine-containing toothpaste also showed superior fluoride uptake compared with those treated with conventional fluoride toothpaste (p < 0.05). Conclusions: Arginine promoted enamel fluoride uptake when used in combination with fluoride, thereby contributing to resistance of enamel to carious demineralization.

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“…Para el efecto se han utilizado diversos métodos que permiten aplicar dispositivos útiles para la medición de la permeabilidad de la dentina, así como el análisis bajo microscopía para la visualización de la oclusión de los túbulos dentinarios. Este último es importante, ya que los túbulos dentinarios establecen el 86% de la resistencia al flujo de líquido en el interior de los mismos; por lo tanto, sí existe una reducción en el diámetro del túbulo se reduce el flujo de líquido, y por ende promueve el alivio a la sensibilidad de la dentina [26][27][28].…”

Section: Análisis De Diámetro De Túbulos Dentinariosunclassified

Pasta dental con nanopartículas de hidroxiapatita efectiva para el sellado de túbulos dentina- rios: un estudio in-vitro.

Soria

2019

CIENCIAS_MEDICAS

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Introducción: La sensibilidad de la dentina afecta al 57% de la población. En Ecuador no existen pastas dentales que empleen nanopartículas de hidroxiapatita (nHAP) como agente que favorece el tratamiento de esta patología. Objetivo: Evaluar mediante Microscopía de Fuerza Atómica (AFM) el efecto del sellado de túbulos dentinarios con pasta dental con nHAP. Métodos: Estudio experimental, in vitro, en 24 discos de dentina de un milímetro de espesor que fueron sometidos a grabado ácido con ácido ortofosfórico al 37% para simular dentina sensible. Se conformaron 4 grupos para recibir cepillado por siete días con nHAP a diferentes concentraciones añadidas a una pasta dental comercial: 0%, 1%, 2% and 3%. La síntesis de nHAP se realizó mediante precipitación de hidróxido de calcio y ácido fosfórico. Con ayuda de AFM se determinó el diámetro de los túbulos dentinarios antes y después del cepillado. Las diferencias fueron analizadas mediante ANOVA entre grupos y la diferencia inicial y final de los diámetros de dentina en cada tratamiento se examinaron con prueba t para grupos pareados y prueba LSD de Fisher con intervalo de confianza (IC) 95% Resultados: La adición de ácido ortofosfórico tuvo un efecto positivo en el aumento del diámetro del túbulo obteniéndose un promedio de 1.74μm (diámetro normal 0.9µm). Después del cepillado se demostró que las pastas dentales con 1, 2, 3% de nHAP cambiaron significativamente el diámetro del túbulo, mientras que, la pasta dental con 0% de nHAP no lo hizo Conclusiones: La adición 3% de nHAP a pasta dental es efectiva para disminuir el diámetro de túbulos dentinarios de dentinas sensibles

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Mode of action studies of a new desensitizing mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride

Abstract: The studies presented in this paper support occlusion of the dentine surface upon the deposition of an arginine-rich layer together with copolymer and phosphate ions from an alcohol-free mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates and 0.05% sodium fluoride.

Cited by 19 publications

References 22 publications

In VitroAbility of a Novel Nanohydroxyapatite Oral Rinse to Occlude Dentine Tubules

In VitroAbility of a Novel Nanohydroxyapatite Oral Rinse to Occlude Dentine Tubules

Arginine promotes fluoride uptake into artificial carious lesionsin vitro

Pasta dental con nanopartículas de hidroxiapatita efectiva para el sellado de túbulos dentina- rios: un estudio in-vitro.

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