Mode of Action, Clinical Use and Toxic Manifestations of Sulfanilamide

Long, Perrin H.; Bliss, Eleanor A.; Feinstone, W. Harry

doi:10.1001/jama.1939.02800020021005

Cited by 42 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the nitro compound representing a further stage of oxidation of the amino group of sulfanilamide than the hydroxylamine is more toxic as well as more bacteriostatic (18). Presumably, this peculiarity is permanent for the individual, for in 3 out of 4 patients who once suffered acute hemolytic anemia from sulfanilamide, readministration of the drug a year later again induced this syndrome and on the identical day (19).…”

Section: Methodsmentioning

confidence: 99%

Acute Hemolytic Anemia From the Sulfonamides

Fox

Ottenberg²

1941

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Acute Hemolytic Anemia From the Sulfonamides

Fox

Ottenberg²

1941

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…The fact that this dosage of 0.5 to 1.0 gram per kilo of rat is, weight for weight, considerably more than the 0.08 to 0.15 gram per kilo generally advocated for man (22), has occasionally prevented the casual observer from recognizing the clinical application of the animal experiments. For example, the Pneumonia Commission of the Medical Society of the State of Pennsylvania (23) was of the opinion that the amount of sulfanilamide required for adequate treatment of clinical pneumonia, calculated from the quantity used in animals, was so great as to be dangerous.…”

Section: Pneumococcic Meningitis Of Ratsmentioning

confidence: 99%

“…Of the 32 rats which recovered from meningitis as a result of treatment, 22 Pneumococcic pneumonia of rats Method. Four groups, each of 15 rats, were infected intratracheally, as described in previous experiments (9, 10, 11, 12) with a mucin suspension of approximately 100 fatal doses of Strain 420 Type III pneumococci.…”

Section: Pneumococcic Meningitis Of Ratsmentioning

confidence: 99%

Sulfapyridine, Sulfanilamide, and Specific Antiserum in Experimental Type Iii Pneumococcic Infections

Cooper¹,

Gross²,

Lewis³

1939

J. Clin. Invest.

View full text Add to dashboard Cite

“…That a similar situation may occur during or after sulfa¬ diazine or sulfathiazole therapy when certain precipi¬ tating factors such as high urinary concentration and partial or complete ureteral obstruction are present is suggested by the 2 cases here reported. REPORT 1,1942. A small calculus 4 mm.…”

Section: Radiopaque Membranous Pyelitismentioning

confidence: 99%

Radiopaque Membranous Pyelitis Following Sulfonamide Therapy

Adams¹

1943

JAMA

View full text Add to dashboard Cite

within three days or less. In these suspensions there was no hemolysis either before or after the addition of saline solution. For patients with a more temporary type of anemia the cells can be stored for five to seven days before being used. It has been shown that the survival time of transfused erythrocytes in stored whole blood decreases rapidly after a storage period of more than seven days.9The English workers 10 have used red cell suspensions in a more or less concentrated form, i. e. with little or no addition of aqueous solutions. This is definitely advantageous for patients with cardiac insufficiency and anemia. It would also make possible the transfusion of larger amounts of cells over a short period of time.In the present work, saline solution has been added to decrease the viscosity of the blood and consequently to facilitate the flow through the transfusion system. It would be just as well to add only 100 or 150 cc. of saline solution to the cells from 500 cc. of blood or to omit the saline solution entirely.11 COMMENTThe main value of red cell transfusions is to increase the erythrocyte count in patients with anemia. After severe hemorrhage, spontaneous recovery of the anemia takes about six weeks or longer. In such a case the daily administration of red cells from a liter of blood will bring the erythrocyte count to normal within a few days. If cells could be made available to the armed forces, it would materially hasten the rehabilitation of wounded men who have suffered from hemorrhage. In patients with severe iron deficiency, the hemoglobin value can be raised rapidly with red cell transfusions. During the gradual destruction of the transfused cells, iron is released for further hemoglobin formation. Red cell transfusions are also effective in other types of anemia. Their use in progressive refractory anemia has already been emphasized. The chief advantage of transfusions with red cell sus¬ pensions over whole blood is the factor of economy. With the widespread use of plasma, great quantities of red cells will continue to be a by-product. Should red cell transfusions come into common use, it will be pos¬ sible to divide the cost of whole blood between the plasma and the cells. If and when red cell suspensions become generally available at a low cost, it is rational that they should be used in larger amounts and more frequently in the treatment of anemia than whole blood is used at the present time. SUMMARYRed cell transfusions are a satisfactory substitute for whole blood transfusions in the treatment of anemia.A patient with progressive refractory anemia has been sustained for a year with transfusions of the red cell suspensions obtained from 25.5 liters of blood. Because red cells are a by-product in the preparation of blood plasma, it is practical to give them in larger amounts and more frequently than heretofore has been the practice with whole blood. 9. Wiener, A. S., and Schaefer, George: Limitations in the Use of Preserved Blood for Transfusions: A Study of the Fate of the Transfused Eryt...

show abstract

Mode of Action, Clinical Use and Toxic Manifestations of Sulfanilamide

Cited by 42 publications

References 13 publications

Acute Hemolytic Anemia From the Sulfonamides

Acute Hemolytic Anemia From the Sulfonamides

Sulfapyridine, Sulfanilamide, and Specific Antiserum in Experimental Type Iii Pneumococcic Infections

Radiopaque Membranous Pyelitis Following Sulfonamide Therapy

Contact Info

Product

Resources

About