Modality dependent changes in event-related potentials correlate with specific cognitive functions in nondemented patients with Parkinson's disease

Abstract

The relationship between event-related potentials (ERPs) and cognitive functioning was studied in patients with Parkinson's Disease (PD) but without dementia. Auditory and visual stimuli were used; 30 subjects participated in the auditory study and 20 in the visual study. Patient groups did not differ with respect to gender, age, education, illness duration, and level of cognitive functioning. Visual stimuli were 2.3 cpd sinusoidal grating patterns randomly presented in an oddball paradigm (oblique vs. vertical spatial orientation). Auditory stimuli were tones presented at 70 dB SPL at a rate of 1.1/second, also using the oddball paradigm (1.5K vs. 1K tones). All patients were given neuropsychological tests to measure verbal fluency, memory, visual spatial perception, and abstract reasoning. P300 and N200 abnormalities correlated with a number of these measures, such that longer ERP latencies were related to lower scores on tests of cognitive functioning. Patterns of results suggest that auditory and visual ERPs correlate with different subsets of neuropsychological functions in nondemented PD patients and that N200 may provide a new metric for clinical use.

Dopaminergic influences on the P300 abnormality in Parkinson's disease

“…This restorative effect of levodopa on abnormal and a significant correlation between the P300 latency and P300 in PD has been repeatedly observed by others performances on frontal lobe related cognitive tasks was [21,33]. Prasher and Findley [24] presented the opposite demonstrated in PD patients [7,15,20,22]. Intravenous results showing a significant prolongation of the P300 injection of levodopa produced significant shortening of latency after long-term levodopa therapy in initially de the P300 latency along with increase in regional cerebral novo patients.…”

“…The evoked cognitive potentials in a healthy Cynomolgus hippocampus and associated brain sites have been regarded monkey [3]. Stanzione et al [32] demonstrated that [7][8][9][10][11][12][13][14][15] as a generator of the P300 [14], and the dopamine has been days of levodopa therapy significantly shortened the P300…”

Event-related potentials and cognition in Parkinson’s disease: An integrative review

“…The degree of global cognitive impairment has been linked to P3b latency by studies showing correlations between P3b latency and neuropsychological measures of general intelligence (Bodis-Wollner et al, 1995;Hansch et al, 1982;Katsarou et al, 2004), processing speed (O'Donnell et al, 1987), and, most frequently, the global score on the MMSE (Lukhanina et al, 2009;Maeshima et al, 2002;Matsui et al, 2007;Sartucci et al, 1990;Stamenović et al, 2005;Tachibana et al, 1997; but see Elwan et al, 1996;Lukhanina et al, 2008).…”

Cognitive Status in Hypothyroid Female Patients: Event-Related Evoked Potential Study

“…Nowadays ERPs are being more commonly used to evaluate quantitatively the cognitive functions in different disease states [20,21,22]. ERPs are those potentials of the EEG which are evoked by the preparation of or for events, and they include an early sensory evoked potential and a late (cognitive) response P300 component [23].…”