Dopaminergic influences on the P300 abnormality in Parkinson's disease

Sohn, Young H.; Kim, Gyung Whan; Huh, Kyu Ha; Kim, Jin-Soo

doi:10.1016/s0022-510x(98)00102-6

Cited by 44 publications

(36 citation statements)

References 33 publications

(13 reference statements)

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“…P300 studies on PD patients have shown that P300 latency is prolonged (6,(12)(13)(14)(15)(16). Similar to the previous studies, we found that P300 latency was prolonged in PD patients compared to the control group (Table 2).…”

Section: Discussionsupporting

confidence: 90%

Demansı olmayan Parkinson hastalarında işitsel olaya bağlı potansiyel (P300) ile kognitif fonksiyonların değerlendirilmesi

Sarıkaya¹,

Yoldaş²,

Yavaşoğlu³

2014

Dusunen Adam

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Objective: Idiopathic Parkinson's disease is a clinical situation characterized by akinesia, rigidity, and tremor, and results from the degeneration of the dopaminergic nervous system. As the disease progresses over time, depression, cognitive dysfunction and alterations in cognitive functions are added to the movement disorder at varying rates. The P300 component is a useful parameter for cognitive processing studies on PD patients, as it is independent from motor skills. The current study aimed to show the effects of the PD on the cognitive functions by evaluating the cognitive functions of IPD patients without dementia with the help of an event related potential component, P300 test. Methods: Thirty-eight patients (25 males and 13 females), ranging in age between 40 and 80 years (mean: 58.8 years), were included to the study and the control group consisted of 39 volunteers (25 males and 14 females), ranging in age between 44 and 84 years (mean: 63.5 years), who did not have a history of cerebrovascular disease, dementia, or depression. The participants were informed about the content and the practice of the study, and informed consent forms were obtained. Neurological examination, standardized mini mental test, Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr Scale, Hamilton Depression Rating Scale (HAM-D), and P300 tests were performed on the patients. Standardized mini mental test (SMMT), HAM-D, and P300 tests were performed in the control group. Results: P300 latencies in Parkinson's patients were significantly prolonged compared to the control group. There was a decrease in P300 amplitude values with increasing HAM-D. Conclusion: P300 latency reflects the rate of stimuli classification by mental process, attention, and cognitive processing. Even if no dementia is present in PD patients, there is a dysfunction in these functions, and it can be demonstrated by the P300 test, which is independent from motor skills.

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Section: Discussionsupporting

confidence: 90%

Demansı olmayan Parkinson hastalarında işitsel olaya bağlı potansiyel (P300) ile kognitif fonksiyonların değerlendirilmesi

Sarıkaya¹,

Yoldaş²,

Yavaşoğlu³

2014

Dusunen Adam

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“…In most of the studies on levodopa effects, nevermedicated PD patients or patients who underwent a drug washout period (12 h -14 days) were tested on an oddball procedure, first off and then on medication. We identified nine studies employing such a study design with five of them demonstrating a reduction of P3b latency following levodopa administration (Lukhanina et al, 2009;Oishi et al, 1996;Sohn et al, 1998;Stanzione et al, 1991;Starkstein et al, 1989). However, P3b latency was not significantly decreased by levodopa in the studies by Chia et al (1995), Kobayashi et al (2004), and Mathis et al (2014) and even increased under levodopa in the study by Prasher and Findley (1991).…”

Section: P3b and Dopaminergic Medication In Pdmentioning

confidence: 99%

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Seer

Lange

Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…Since dopaminergic function is an important determinant for P300 components [4,6] and evidence suggests a relationship between genetic effects and P300 components [7,8], several studies have investigated the association between the dopamine D2 receptor (DRD2) genetic polymorphism and P300. In 1994, Noble et al [9], first demonstrated relatively prolonged P300 latency for boys bearing the A1 allele of the DRD2 TaqI A polymorphism in comparison to A2-allele analogs.…”

Section: Introductionmentioning

confidence: 99%

Association Analysis of Two Dopamine D2 Receptor Gene Polymorphisms and P300 Event-Related Potential in Depressive Patients

Chen

Yu²,

Chen

et al. 2002

Neuropsychobiology

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Previous Western studies have demonstrated an association between the dopamine D2 receptor (DRD2) TaqI A polymorphism and components of P300 event-related potential. This finding was not replicated in our previous study of a sample of normal young Chinese females, however. In the current study of 105 patients diagnosed with major depression, we have further explored the association between the P300 components, and, the DRD2 TaqI A polymorphism and another functional DRD2 -141Cins/Del polymorphism. The results demonstrate that neither polymorphism is associated with P300 amplitude or latency, even after gender analysis. We suggest that these two DRD2 polymorphisms have no major effects on P300 components for the Chinese population. The association between the DRD2 polymorphism and P300 components may depend on ethnicity, the psychiatric state of the subjects, or the investigative paradigms used.

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Dopaminergic influences on the P300 abnormality in Parkinson's disease

Cited by 44 publications

References 33 publications

Demansı olmayan Parkinson hastalarında işitsel olaya bağlı potansiyel (P300) ile kognitif fonksiyonların değerlendirilmesi

Demansı olmayan Parkinson hastalarında işitsel olaya bağlı potansiyel (P300) ile kognitif fonksiyonların değerlendirilmesi

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Association Analysis of Two Dopamine D2 Receptor Gene Polymorphisms and P300 Event-Related Potential in Depressive Patients

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