Modafinil improves daytime sleepiness in patients with mild to moderate obstructive sleep apnoea not using standard treatments: a randomised placebo-controlled crossover trial

Chapman, Jennifer; Kempler, Liora; Chang, Catherina L.; Williams, Shaun C; Sivam, Sheila; Wong, Keith; Yee, Brendon J.; Grunstein, Ronald R.; Marshall, Nathaniel S.

doi:10.1136/thoraxjnl-2013-203796

Cited by 33 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacologically, donepezil improved OSA in AD significantly in a double blind, placebo‐controlled study with improvements observed in AHI and oxygen saturations (Moraes et al ., ). Modafinil was found to improve daytime sleepiness (Chapman et al ., ) in OSA patients and also improved behavioural alertness when used in adjunct with CPAP (Dinges & Weaver, ). Armodafinil when used along with CPAP improved alertness as well as long‐term episodic memory in OSA (Hirshkowitz et al ., ; Roth et al ., ).…”

Section: Interventionsmentioning

confidence: 99%

Obstructive sleep apnoea and dementia: is there a link?

Shastri

Bangar

Holmes

2015

Int J Geriatr Psychiatry

View full text Add to dashboard Cite

While there are numerous studies that establish a clear relationship between obstructive sleep apnoea, cognitive decline and dementia, more work is needed in understanding the mechanism and processes involved. A detailed understanding of pathophysiology of sleep and the relationship with cognitive decline will be vital in addressing the possibility of averting a likely reversible cause of dementia or cognitive decline.

show abstract

Section: Interventionsmentioning

confidence: 99%

Obstructive sleep apnoea and dementia: is there a link?

Shastri

Bangar

Holmes

2015

Int J Geriatr Psychiatry

View full text Add to dashboard Cite

show abstract

“…Studies using modafinil, a nonamphetamine stimulant medication used in the treatment of ADHD, have shown significant reduction of excessive daytime sleepiness associated with OSA in both objective and subjective measures with this medication. 59 , 60 In most guidelines, modafinil is recommended for use in patients who have residual daytime sleepiness despite optimal use of CPAP. 20 – 22 , 26 , 28 , 61 …”

Section: Methodsmentioning

confidence: 99%

Obstructive sleep apnea: management considerations in psychiatric patients

Heck¹,

Zolezzi²

2015

NDT

View full text Add to dashboard Cite

Psychiatric disorders and obstructive sleep apnea (OSA) are often comorbid. However, there is limited information on the impact of psychotropic medications on OSA symptoms, on how to manage psychiatric pharmacotherapy in patients presenting with OSA, or on the effectiveness and challenges of OSA treatments in patients with comorbid mental illness. As such, the objective of this article is to provide an overview of some epidemiological aspects of OSA and treatment considerations in the management of OSA in individuals with comorbid psychiatric disorders. Predefined keywords were used to search for relevant literature in electronic databases. Data show that OSA is particularly prevalent in patients with psychiatric disorders. The medical care that patients with these comorbidities require can be challenging, as some of the psychiatric medications used by these patients may exacerbate OSA symptoms. As such, continuous positive airway pressure continues to be the first-line treatment, even in patients with psychiatric comorbidity. However, more controlled studies are required, particularly to determine continuous positive airway pressure compliance in patients with mental illness, the impact of treating OSA on psychiatric symptoms, and the impact of the use of psychotropic medications on OSA symptoms.

show abstract

“…Second, we have examined the effects of the stimulants on the risk of the hospitalization for an MVA injury in the OSA patients. Previous studies have found that stimulants would improve the OSA patients driving performance [34,35]. Previous articles of systematic reviews and meta-analysis have reported the association between OSA and the motor vehicle crashes, and the effects of CPAP therapy [10,36].…”

Section: Comparison Of This Study To Previous Literaturesmentioning

confidence: 99%

Stimulants associated with reduced risk of hospitalization for motor vehicle accident injury in patients with obstructive sleep apnea-a nationwide cohort study

et al. 2020

View full text Add to dashboard Cite

Background: The risk of injury directly related to hospitalization for motor vehicle accidents (MVAs) in the obstructive sleep apnea (OSA) patients has not been thoroughly understood. Our study aimed to examine the association between the OSA and the hospitalization for an MVA injury. Methods: This retrospective cohort study used Taiwan's National Health Insurance Research Database (NHIRD) between 2000 and 2015. The OSA patients aged ≥20 years by age, sex, and index-year matched by non-OSA controls were enrolled (1:3). We used the Cox proportional regression model to evaluate the association between the OSA and the hospitalization for an MVA injury. Results: The incidence rate of hospitalization for an MVA injury was higher in the OSA cohort (N = 3025) when compared with the non-OSA controls (N = 9075), as 575.3 and 372.0 per 100,000 person-years, respectively (p < 0.001). The Kaplan-Meier analysis showed that the OSA cohort had a significantly higher incidence of hospitalization for the MVA injury (log-rank test, p < 0.001). After adjusting for the covariates, the risk of hospitalization for the MVA injury among the OSA was significantly higher (hazard ratio [HR] =2.18; 95% confidence interval [CI] = 1.79-2.64; p < 0.001). Stimulants usage was associated with a nearly 20% decrease in the risk of an overall hospitalization for an MVA injury in the OSA patients. Conclusions: This study provides evidence that patients with OSA are at a twofold higher risk of developing hospitalization for an MVA injury, and the usage of modafinil and methylphenidate was associated with a lower risk of an overall hospitalization for the MVA injury.

show abstract

Modafinil improves daytime sleepiness in patients with mild to moderate obstructive sleep apnoea not using standard treatments: a randomised placebo-controlled crossover trial

Cited by 33 publications

References 28 publications

Obstructive sleep apnoea and dementia: is there a link?

Obstructive sleep apnoea and dementia: is there a link?

Obstructive sleep apnea: management considerations in psychiatric patients

Stimulants associated with reduced risk of hospitalization for motor vehicle accident injury in patients with obstructive sleep apnea-a nationwide cohort study

Contact Info

Product

Resources

About