Modafinil During 64 Hr of Sleep Deprivation: Dose-Related Effects on Fatigue, Alertness, and Cognitive Performance

Baranski, Joseph V.; Cian, Corinne; Esquivié, Dominique; Pigeau, Ross; Raphel, Christian

doi:10.1207/s15327876mp1003_3

Cited by 37 publications

(32 citation statements)

References 33 publications

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“…Bright light has an acute effect on alertness 96) , independent of its phase-shifting effect, which makes it useful for this purpose, especially in combination with caffeine [97][98][99] . The stimulant modafinil has shown promise in alleviating the effects of sleep deprivation [100][101][102][103] . For a review of pharmacological treatments for shift work, see Åkerstedt et al 104) .…”

Section: Rapid Rotation Schedulesmentioning

confidence: 99%

Circadian-Based New Technologies for Night Workers.

Horowitz

Tanigawa

2002

INDUSTRIAL HEALTH

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Night work is becoming increasingly common. Unfortunately, humans are physiologically unsuited to inverted schedules, leading to negative consequences for shift workers, employers, and society. The circadian and homeostatic processes which govern sleepiness and alertness are improperly aligned for night workers. We review a number of laboratory studies designed to treat circadian maladaptation to night work by shifting the circadian clock with light, exercise, or melatonin. There is substantial evidence that bright light treatments can successfully overcome the circadian misalignments associated with night work. The evidence for the efficacy of non-photic synchronizers such as exercise and exogenous melatonin is equivocal. Nevertheless, our expanding scientific understanding of the nature of the problem has generated a promising range of options for shift workers.

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Section: Rapid Rotation Schedulesmentioning

confidence: 99%

Circadian-Based New Technologies for Night Workers.

Horowitz

Tanigawa

2002

INDUSTRIAL HEALTH

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“…In recent years, modafinil has become a means of alleviating the symptoms of fatigue among military personnel when scheduling and other behavioral countermeasures have been ineffective (Baranski, Pigeau, Dinich, & Jacobs, 2004). The tendency of some personnel to prefer modafinil to dextroamphetamine may be due to the side effects associated with dextroamphetamine use such as difficulty in obtaining recovery sleep (Baranski, Cian, Esquivié, Pigeau, & Raphel, 1998) and concerns over the effect on the cardiovascular system (Caldwell, 2001). In addition, studies have found that modafinil is less addictive and has fewer side effects than dextroamphetamine (Baranski et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, studies have found that modafinil is less addictive and has fewer side effects than dextroamphetamine (Baranski et al, 2004). Research has indicated that administering modafinil to treat fatigue associated with inadequate sleep can lead to significant improvement over placebo on measures like the Psychomotor Vigilance Task (PVT; Wesensten, Killgore, & Balkin, 2005) as well as tests of reaction time, mental addition, and short-term memory (Baranski et al, 1998). When modafinil was administered to night-shift workers who had been diagnosed with shift-work sleep disorder, the results indicated that response time and number of lapses on the PVT decreased from baseline performance, and these workers reported fewer accidents and near-accidents during the drive home after work (Czeisler et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Modafinil and OTC Stimulants on Physical and Cognitive Performance

Caldwell¹,

Hartzler²,

Levin³

et al. 2016

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“…Although it was noted that some tasks were more sensitive to sleep deprivation than others, modafinil still maintained superior performance during the sleep deprivation on the following tasks: reaction time task, mathematical processing, memory search, spatial processing, unstable tracking, and grammatical reasoning. Baranski, Cian, Esquivie, Pigeau, and Raphel (1998) administered a cognitive test battery during a period of sleep deprivation, and used three different groups at three different doses over 24 hours to investigate what effect modafinil would have at maintaining performance levels. The 300 mg treatment maintained participants at near base-line levels, the 150 mg dose provided some relief, and the 50 mg dose was not statistically different form the placebo control group.…”

Section: Introductionmentioning

confidence: 99%

“…A study by showed 200 mg administered every eight hours enhanced vigilance during sixty hours of sleep deprivation. In a study by Baranski, et al (1998), participants given a dosage of 100 mg every eight hours maintained cognitive performance levels throughout 64 hours of sleep deprivation. This study found that doses of 50 mg every eight hours did not bolster cognitive performance.…”

Section: Introductionmentioning

confidence: 99%

An Assessment of Modafinil for Vestibular and Aviation-Related Effects

Eddy¹,

Gibbons²,

Storm³

et al. 2005

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REPORT DOCUMENTATION PAGEOMB maintaining the data needed, and completing and reviewing this collection of information, Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information , 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)2. REPORT TYPE 3. DATES COVERED (From -To) October Approved for public release; distribution unlimited. SUPPLEMENTARY NOTES ABSTRACTThe goal of this study was to provide data concerning both the efficacy and the safe-to-fly dosage of a relatively unique compound, modafinil. Previous studies have indicated that modafinil holds promise as an effective wake-promoting agent for military personnel assigned to sustained operations without the common side effects associated with amphetamine-like substances. The present research was conducted to examine whether 200 or 400 mg doses of modafinil have any effect upon human vestibular functioning at night, to verify its cognitive enhancement capabilities during a short-term, sleep-loss setting, and to document the presence/absence of subjective symptoms. Other measures were investigated for possible effects of over-confidence or dehydration. ....................................................................................... .................................................................................... .............................................................................. ............................................................................................ 34 Other Physiological M easures ....................................................................................... 35 Oral Temperature ....................................................................................................... 35 Heart Rate ....................................................................................................................... 35 Blood Pressure .......................................................................................................... .................................................................................................................. 38 Urine Assay for M odafinil .......................................................................................... 39 DISCUSSION .................................................................................................................... m easures ..................................................................................................... 31 Figure 10. Representative scatter plots of observed performance plotted against participant estim...

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Modafinil During 64 Hr of Sleep Deprivation: Dose-Related Effects on Fatigue, Alertness, and Cognitive Performance

Cited by 37 publications

References 33 publications

Circadian-Based New Technologies for Night Workers.

Circadian-Based New Technologies for Night Workers.

The Effects of Modafinil and OTC Stimulants on Physical and Cognitive Performance

An Assessment of Modafinil for Vestibular and Aviation-Related Effects

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