The commonest saying goes as "cancer has no answer," we have really come a long way in that aspect. From being able to detect and diagnose the disease early, effective treatment modalities, improvement in therapeutic outcome and even effective palliative measures. The research focus emphasized upon detecting preventable risk factors. Tobacco a Global culprit is often discussed as the most important risk factor for cancer. Modern day life and with its so-called stress measures are the ones often been blamed without a concrete scientific evidences. Psychological makeup of a person, emotional stress and cellular phones are intricately associated with a modern lifestyle. In this chapter we would be focusing upon the causal relationship between these factors and malignancy with available scientific literature. At the end we would present possible measures to avoid them and any future research areas to be looked upon.