Mo1933 Development of Esophageal and Anal Cancer Patient Derived Tumor Xenograft (PDTX) Models Using a Novel Implantation Technique

Read, Matthew; Bernardi, Maria-Pia; Liu, David; Fennell, Christina M.; Ramsay, Robert G.; Heriot, Alexander; Duong, Cuong; Phillips, Wayne A.; Clemons, Nicholas J.

doi:10.1016/s0016-5085(14)62523-3

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Subrenal Capsule Transplantation1

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2021

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“…Intramuscular transplantation. Read et al (22) used matrix gel-coated tumor tissue sections and implanted them into the lateral subcutaneous or posterior muscles of immunocompromised mice. PDTX models of esophageal and anal cancer were successfully constructed using fresh and cryopreserved biopsy tumor tissues.…”

Section: Subrenal Capsule Transplantationmentioning

confidence: 99%

Current research developments of patient‑derived tumour xenograft models (Review)

et al. 2021

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Patient-derived tumor xenograft (PDTX) models are established by transferring patient tumors into immunodeficient mice. In these murine models, the characteristics of the primary tumor are retained, including the microenvironment of tumor cell growth and histopathology. Due to this, it has become the most reliable in vivo human cancer model. However, the success rates differ by type of tumor, site of transplantation and tumor aggressiveness. Subcutaneous transplantation is a standard method for PDTX, and subrenal capsule transplantation improves the engraftment rate. Recently, PDTX models are frequently used in the fields of precision medicine, predictive biomarkers, evaluation of drug efficacy and preclinical research on tumor immunotherapeutic drugs. The aim of the present article was to review the establishment, clinical applications and limitations of the PDTX model in tumor research.

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Section: Subrenal Capsule Transplantationmentioning

confidence: 99%