Mo1879 EGFR in Gastroesophageal Reflux Disease, Barrett's, Esophagus, and Esophageal Adenocarcinoma

Pretto, Guilherme Gonçalves; Gurski, Richard Ricachenevsky; Navarini, Daniel; Binato, Marcelo; Meurer, Luíse; Costamilan, Laura Zambonato; Mazzini, Guilherme D.; Costa, Gabriela G.

doi:10.1016/s0016-5085(12)64221-8

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various studies have shown that the pathogenesis and development of multiple tumors requires modulation of EGF-EGFR pathway function, and this pathway is a major target for cancer therapy. EGFR, which is the specific receptor for EGF, is overexpressed in various tumors and is often associated with unfavorable prognosis (Pretto et al, 2012). High EGFR expression frequently causes abnormal cell differentiation, which impairs cell adhesion, leading to tumor metastasis.…”

Section: Discussionmentioning

confidence: 99%

Expression and prognostic influence of NF-κB and EGFR in esophageal cancer

Zhang¹,

Zhang²,

Song³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The goal of this study was to investigate the expression profiles of nuclear factor-kappa B (NF-κB) and epidermal growth factor receptor (EGFR) in esophageal cancer and to determine their association with tumor prognosis. This study included 40 esophageal cancer patients [22 men and 18 women; average age = 62.7 ± 3.9 years; tumor-node-metastasis (TNM) staging: 12 patients with stage I, 13 patients with stage II, and 15 patients with stage III disease]. Tumor tissues and tumor-adjacent tissue specimens were collected during radical resections at our hospital. Immunohistochemical staining was used to examine these tissues for NF-κB and EGFR expression. Follow-up of all patients included gathering information such as the 3-year survival rate. We found that NF-κB and EGFR expression was significantly higher in tumor tissues compared to tumor-adjacent normal tissues. Expression was not related to gender or age, but was positively associated with the degree of tumor infiltration. NF-κB and EGFR expression levels gradually increased with higher TNM stage, but this difference was not significant. Follow-up results showed that 16820 Y.Q. Zhang et al.©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16819-16826 (2015) patients with higher NF-κB and EGFR levels had a lower survival rate and unfavorable prognosis. In conclusion, we found that NF-κB and EGFR expression was significantly elevated during the occurrence and development of esophageal carcinoma, and expression of these factors appears to be correlated with cancer progression. Higher expression of both genes is associated with an unfavorable prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%