Mo1607 – Baseline Predictive Factors for Fore and Hind Gut Response to Long-Term Gi Electrical Stimulation

Effectiveness of gastric electrical stimulation in gastroparesis: Results from a large prospectively collected database of national gastroparesis registries

“…Older work has shown that GES can also improve pancreatic function in patients with the symptoms of gastroparesis, likely via a vagal mechanism . Recent work with temporary and permanent GES has reported an effect on the small bowel and colon . However, one randomized sensory study did not reveal a central effect of GES in humans .…”

“…The anatomic measure of gastric Cajal cells have been reported to effect outcome as measured by full thickness biopsy, although this can now be performed less invasively . Several studies have now shown that baseline gastric electrical activity, particularly when done with multi‐point (low‐resolution) recordings of the gastric mucosa, can predict outcome to temporary and permanent GES …”

“…34 Several studies have now shown that baseline gastric electrical activity, particularly when done with multi-point (low-resolution) recordings of the gastric mucosa, can predict outcome to temporary and permanent GES. 11,35,36 One of the other difficulties with device trial for gastroparesis is that the mechanism of action of GES has not been well understood. Besides a documented central effect in several studies, 37,38 recent NIH DiaComp work has reported other mechanisms of a Propensity scores were calculated using logistic regression with the binary indicator for the GES implantation as an outcome.…”

“…14 Recent work with temporary and permanent GES has reported an effect on the small bowel 40 and colon. 35,41 However, one randomized sensory study did not reveal a central effect of GES in humans. 42 Other work, however, a Linear regression was used with the change in GCSI total score as an outcome.…”

An Adhesive‐Integrated Stretchable Silver‐Silver Chloride Electrode Array for Unobtrusive Monitoring of Gastric Neuromuscular Activity

“…[5][6][7] However, recent findings with invasive recordings show that electrical patterns of the stomach align well with disease diagnosis, symptoms, as well as treatment response. [8][9][10][11][12] As such, there is a unique opportunity to extract this spatial electrical information non-invasively.GI smooth muscle contractions are governed by underlying rhythmic bio-electrical signals, known as slow waves, that are generated by oscillating pacemaker cells, the interstitial cells of Cajal. These slow waves have a frequency of 0.05 Hz in the stomach and underlie the electrogastrogram (EGG) signal that Here, an unobtrusive, adhesive-integrated electrode array for continuous monitoring of stomach electric activity is introduced.…”